The effect of various vasoactive compounds upon the uterine vascular bed.

Abstract:

:The effects of various vasodilators on the uterine vascular bed were investigated in nonpregnant, oophorectomized sheep with chronically implanted flow probes and catheters inserted into branches of the uterine arteries. A 1 mug dose of estradiol-17beta (0.224 muM) produces a maximum uterine blood flow response after intra-arterial injection. Adenosine (24 muM) and bradykinin (0.02 muM) were observed to increase blood flow to levels achieved by 1 mug of estradiol-17beta. Acetylcholine, isoproterenol, and histamine were less potent in their vasodilator activity. Atropine, propanolol, and diphenhydramine did not inhibit the increase of uterine blood flow induced by estrogens.

journal_name

Am J Obstet Gynecol

authors

Resnik R,Killam AP,Barton MD,Battaglia FC,Makowski EL,Meschia G

doi

10.1016/0002-9378(76)90593-7

subject

Has Abstract

pub_date

1976-05-15 00:00:00

pages

201-6

issue

2

eissn

0002-9378

issn

1097-6868

pii

0002-9378(76)90593-7

journal_volume

125

pub_type

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