Isoxsuprine-induced release of pulmonary surfactant in the rabbit fetus.

Abstract:

:Rabbit fetuses were injected intramuscularly with 0.5 mg. of isoxsuprine on the twenty-eighth day of gestation. They were killed in utero four hours after the injection, and fetal pulmonary fluid (FPF) was collected through a tracheal catheter. The quantity of FPF and the lung weight/body weight ratio were both significantly less in the isoxsuprine-treated fetuses than in control fetuses. Surface activity, evaluated with pulsating bubble, and the lecithin/sphingomyelin (L/S) ratio were greater in FPF from isoxsuprine-treated animals than in control samples. We concluded that isoxsuprine is able to dehydrate the fetal lung and cause a release of surfactant stored in type II pneumocytes. This latter conclusion was supported by a significant decrease in the number of lamellar inclusions observed in these cells.

journal_name

Am J Obstet Gynecol

authors

Enhorning G,Chamberlain D,Contreras C,Burgoyne R,Robertson B

doi

10.1016/0002-9378(77)90744-x

subject

Has Abstract

pub_date

1977-09-15 00:00:00

pages

197-202

issue

2

eissn

0002-9378

issn

1097-6868

pii

0002-9378(77)90744-X

journal_volume

129

pub_type

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