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The potential role of prolactin as a modulator of the secretion of proinflammatory mediators in chorioamniotic membranes in term human gestation.

Abstract：

OBJECTIVE:To test the effect of prolactin (PRL) on expression of proinflammatory cytokines and matrix metallopeptidase 9 (MMP-9) in vitro. STUDY DESIGN:Tissue explants were incubated from 4 to 48 hours alone or in the presence of 500 ng/mL PRL, and mRNA expression in tissues and secretion of interleukin (IL)-1β, tumor necrosis factor alpha (TNF-α), MMP-2, and MMP-9 was quantified. RESULTS:Fetal membranes secreted IL-1β, TNF-α, and MMP-9 in culture with consistent low concentration during the first 24 hours and then increased progressively. The presence of PRL during explant incubation significantly decreased the patterns of IL-1β, TNF-α and MMP-9 secretion along culture (P < .001). MMP-2 secretion was unaffected by PRL. The relative basal expression of IL-1β mRNA (1.2 ± 0.87) was reduced by 80% in the presence of PRL after 32 hours of incubation of the membranes (P = .001). The expression of the TNF-α mRNA was not modified by the presence of PRL (0.06 ± 0.01) compared with the basal expression levels (0.05 ± 0.01). MMP-9 mRNA basal expression (0.018 ± 0.008) was significantly reduced (P = .001) in the presence of PRL after 32 hours (0.002 ± 0.0005). CONCLUSION:PRL may be a potential candidate as a key signal controlling the expression of signals related to the proinflammatory reaction associated with human labor.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Zaga-Clavellina V,Parra-Covarrubias A,Ramirez-Peredo J,Vega-Sanchez R,Vadillo-Ortega F

doi

10.1016/j.ajog.2014.01.039

subject

Has Abstract

pub_date

2014-07-01 00:00:00

pages

48.e1-6

issue

1

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(14)00110-0

journal_volume

211

pub_type

杂志文章

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