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Effect of antenatal exposure to Saint John's wort (Hypericum) on neurobehavior of developing mice.

Abstract：

OBJECTIVE:We conducted, in a randomized, placebo-controlled manner, behavioral testing on mice offspring exposed antenatally to the herbal antidepressant Saint John's wort (Hypericum ). STUDY DESIGN:A daily dose of Saint John's wort (0.75 mg/g of food consumed), equivalent to that in human beings according to body surface, was chosen because it has been shown to cause an antidepressant effect in adult mice. CD-1 mice were randomly assigned to consume either Saint John's wort (n = 45) or a placebo (n = 45) for 2 weeks before conception and throughout gestation. Behavioral testing consisted of early developmental tasks of geotaxis, separation vocalization, and homing, followed by motor, anxiety, and depression assessments into adulthood. RESULTS:Birth weights of male offspring were less in the Saint John's wort group than in the placebo group (1.68 vs. 1.75 g; P<.01). Offspring in both treatment groups showed no long-term statistical differences in early developmental tasks, locomotor activity, and exploratory behavior throughout development. Performances on a depression task (forced swim) and on anxiety tasks (elevated plus maze as juveniles and adults) revealed no differences between treatment groups. CONCLUSION:Antenatal exposure to a therapeutic dose of Saint John's wort showed no long-term deficits on selected behavioral tasks by developing mice offspring.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Rayburn WF,Christensen HD,Gonzalez CL

doi

10.1067/mob.2000.108889

subject

Has Abstract

pub_date

2000-11-01 00:00:00

pages

1225-31

issue

5

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(00)15690-X

journal_volume

183

pub_type

杂志文章

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