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Endocrine impact of pure estradiol replacement in postmenopausal women: alterations in anterior pituitary hormone release and circulating sex steroid hormone concentrations.

Abstract：

:Thirteen healthy postmenopausal volunteers were studied under basal conditions and at intervals (days 1, 5, 10, and 30) after intravaginal placement of a polysiloxane ring impregnated with 400 mg of estradiol. Mean serum estradiol concentrations rose 26-fold with a twofold increase in serum estrone concentrations. Serum delta 4-androstenedione, dehydroepiandrosterone sulfate, and total testosterone did not change, but absolute and percent free testosterone concentrations declined significantly by day 5. Concurrently, serum concentrations of immunoactive follicle-stimulating hormone declined progressively, while serum luteinizing hormone and free alpha-subunit concentrations exhibited a biphasic pattern of suppression. Serum levels of prolactin increased monophasically and those of growth hormone, somatomedin C, and thyroid-stimulating hormone did not change.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Veldhuis JD,Samojlik E,Evans WS,Rogol AD,Ridgeway CE,Crowley WF,Kolp L,Checinska E,Kirschner MA,Thorner MO

doi

10.1016/0002-9378(86)90821-5

subject

Has Abstract,Author List Incomplete

pub_date

1986-08-01 00:00:00

pages

334-9

issue

2

eissn

0002-9378

issn

1097-6868

pii

0002-9378(86)90821-5

journal_volume

155

pub_type

杂志文章

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