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Blocking of human fertilization in vitro by sera with sperm-immobilizing antibodies.

Abstract：

:Serum samples with sperm-immobilizing antibody activity from six women were examined for ability to block sperm-egg interaction by a zona penetration test where human follicular ova matured in vitro were used. Exposure of spermatozoa from a fertile healthy donor to the sera impaired binding to and penetration through the zona pellucida of the spermatozoa completely in five cases and incompletely in one case. Successful fertilization in vitro was achieved by using fetal cord serum instead of autoserum of the patient included in the in vitro fertilization and embryo transfer program. These results suggest that interference with sperm-egg interaction may be an additional mechanism of infertility that is caused by antisperm antibodies.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Kamada M,Daitoh T,Hasebe H,Irahara M,Yamano S,Mori T

doi

10.1016/s0002-9378(85)80125-3

subject

Has Abstract

pub_date

1985-10-01 00:00:00

pages

328-31

issue

3

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(85)80125-3

journal_volume

153

pub_type

杂志文章

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