Catecholamine physiology in the ovine fetus. I. Gestational age variation in basal plasma concentrations.

Abstract:

:Fifty-five ewes with chronically catheterized singleton gestations were studied to assess changes in basal concentrations of fetal catecholamines with increasing gestational age. All pregnancies were time dated, and measurements of catecholamines were conducted at least 5 days after placement of fetal catheters when fetal metabolic parameters had normalized. Plasma concentrations of catecholamines were measured by radioenzymatic assay. Additionally, fetal heart rate (FHR) and corrected mean blood pressure were analyzed in 32 of the fetuses for correlation with plasma levels of catecholamines. Multiple regression analysis revealed significant inverse correlations of fetal plasma concentrations of catecholamines with gestational age, as follows: norepinephrine (p less than 0.001), epinephrine (p less than 0.05), and dopamine (p less than 0.01). FHR correlated inversely with gestational age (p less than 0.001) and positively with circulating levels of norepinephrine (p less than 0.001).

journal_name

Am J Obstet Gynecol

authors

Palmer SM,Oakes GK,Lam RW,Oddie TH,Hobel CJ,Fisher DA

doi

10.1016/0002-9378(84)90157-1

subject

Has Abstract

pub_date

1984-06-15 00:00:00

pages

420-5

issue

4

eissn

0002-9378

issn

1097-6868

pii

0002-9378(84)90157-1

journal_volume

149

pub_type

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