当前位置： SCI文献检索 > AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY期刊下所有文献 > Reduced progression of endometrial hyperplasia with oral mTOR inhibition in the Pten heterozygote murine model.

Reduced progression of endometrial hyperplasia with oral mTOR inhibition in the Pten heterozygote murine model.

Abstract：

OBJECTIVE:Phosphatase and tensin homolog (PTEN) mutations are associated with human endometrial cancers, and PTEN heterozygote(+/-) mice have a high rate of endometrial neoplasia. The objective of this study was to evaluate an oral mTOR inhibitor (mTOR-I) on the reduction of endometrial hyperplasia in an animal model. STUDY DESIGN:Three groups of 10 female mice were treated from age 20-26 weeks: group A, Pten wild type with mTOR-I; group B, Pten+/- with placebo; and group C, Pten +/- with mTOR-I. Rates of hyperplasia and markers of proliferation and apoptosis were evaluated. RESULTS:Higher grade hyperplasia occurred in a significantly greater percentage of the untreated Pten+/- group B (80%; 8/10) compared with groups A (0%; 0/10) and C (20%; 2/10; P < .02). The treated Pten+/- mTOR-I group C also demonstrated significantly increased apoptosis (P < .002) and decreased proliferation index (P < .02) compared with the untreated group B. CONCLUSION:Oral mTOR inhibition decreases the progression of endometrial hyperplasia in the Pten heterozygote murine model through decreased cell proliferation and increased apoptosis.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Milam MR,Celestino J,Wu W,Broaddus RR,Schmeler KM,Slomovitz BM,Soliman PT,Gershenson DM,Wang H,Ellenson LH,Lu KH

doi

10.1016/j.ajog.2006.10.872

subject

Has Abstract

pub_date

2007-03-01 00:00:00

pages

247.e1-5

issue

3

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(06)02137-5

journal_volume

196

pub_type

杂志文章

相关文献

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY文献大全
  • Neuroendocrinology of opioid peptides and their role in the control of gonadotropin and prolactin secretion.

    abstract：:Substantial evidence now exists to indicate that the endogenous hypothalamic opioidergic mechanism(s) represents one of the important controlling systems for release of gonadotropin-releasing hormone. Modulations of frequency and amplitude of the secretory activity of gonadotropin-releasing hormone appears to be media...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章,评审

    doi：10.1016/s0002-9378(85)80162-9

    authors： Yen SS,Quigley ME,Reid RL,Ropert JF,Cetel NS

    更新日期：1985-06-15 00:00:00

  • Tamoxifen and endometrial carcinoma: alterations in estrogen and progesterone receptors in untreated patients and combination hormonal therapy in advanced neoplasia.

    abstract：:Estrogen receptors and progesterone receptors were measured in tumors from patients with previously untreated endometrial carcinoma before and after a 5-day course of tamoxifen citrate. On initial biopsy, 13 of 25 tumors (52%) were progesterone receptor-positive, whereas 21 of 25 tumors (84%) were progesterone recepto...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(84)90187-x

    authors： Carlson JA Jr,Allegra JC,Day TG Jr,Wittliff JL

    更新日期：1984-05-15 00:00:00

  • Genetic amniocentesis in twin gestations.

    abstract：:Among 1,613 women studied with routine ultrasonography prior to genetic amniocentesis at Northwestern University Medical School, 25 of 26 multiple gestations were detected. Sampling of fluid from both amniotic sacs was requested by 20 women with twin gestations in which both fetuses were ultrasonographically determine...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(80)90029-0

    authors： Elias S,Gerbie AB,Simpson JL,Nadler HL,Sabbagha RE,Shkolnik A

    更新日期：1980-09-15 00:00:00

  • Late preterm births: irreducible because E = mc2.

    abstract：:Defined as delivery at 34(0/7)-36(6/7) weeks, late preterm births have increased by 15% between 1992 and 2002 and currently they occur in about 8% of singletons and 35% of multiple gestations. Compared with newborns at 39 weeks, late preterm births undeniably have a significantly higher rate of morbidity (respiratory ...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2011.02.076

    authors： Chauhan SP

    更新日期：2011-06-01 00:00:00

  • Psychometric testing as a basis for counseling patients choosing a method of contraception. A retrospective survey.

    abstract：:To investigate the merits of using psychometric testing as a predictive adjunct to counseling patients in the choice of a contraceptive method, 134 family-planning patients using an oral contraceptive for one year or longer completed the Neuroticism Scale Questionnaire. Clinic records of these patients were examined t...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(76)90016-8

    authors： Brooks GG,Butcalis MR

    更新日期：1976-01-01 00:00:00

  • Does length of labor vary by maternal age?

    abstract：OBJECTIVE:The purpose of this study was to examine lengths of first and second stages of labor across maternal age groups to determine whether different norms should be established. STUDY DESIGN:We conducted a retrospective cohort study of all laboring, term, singleton, and cephalic deliveries at a single institution ...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2007.06.058

    authors： Greenberg MB,Cheng YW,Sullivan M,Norton ME,Hopkins LM,Caughey AB

    更新日期：2007-10-01 00:00:00

  • Candida albicans: cellular immune system interactions during different stages of the menstrual cycle.

    abstract：:Candidal vaginitis most often recurs during pregnancy and in the late luteal phase just before menstruation. We examined the influence of the stage of the menstrual cycle on the cellular immune response to Candida albicans, the efficiency of C. albicans germination in sera, and the ability of products from activated l...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(89)90649-2

    authors： Kalo-Klein A,Witkin SS

    更新日期：1989-11-01 00:00:00

  • Placental transfer of sulindac and its active sulfide metabolite in humans.

    abstract：OBJECTIVE:Our aim was to investigate whether the human placenta is permeable to sulindac or its active sulfide metabolite. STUDY DESIGN:Nine pregnant patients (median gestational age [range]: 31.8 [24.3 to 36.4] weeks) were given a 200 mg oral dose of sulindac 5.5 (4.4 to 6.7) hours before 18 intravascular transfusion...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 临床试验,杂志文章

    doi：10.1016/0002-9378(95)90016-0

    authors： Kramer WB,Saade G,Ou CN,Rognerud C,Dorman K,Mayes M,Moise KJ Jr

    更新日期：1995-03-01 00:00:00

  • The correlation of biochemical monitoring versus umbilical flow velocity measurements of the human fetus.

    abstract：:The pulsatility index of the fetal umbilical arteries was evaluated in 14 high-risk pregnant patients delivered by cesarean section between 30 and 35 weeks of gestation. Transabdominal cord sampling by ultrasonic guidance was performed on 10 of these patients. Umbilical arterial and venous blood was obtained in all pa...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(88)90418-8

    authors： Ferrazzi E,Pardi G,Bauscaglia M,Marconi AM,Gementi B,Bellotti M,Makowski EL,Battaglia FC

    更新日期：1988-11-01 00:00:00

  • Night sweats, sleep disturbance, and depression associated with diminished libido in late menopausal transition and early postmenopause: baseline data from the Herbal Alternatives for Menopause Trial (HALT).

    abstract：OBJECTIVE:The objective of the study was to evaluate the association of depression, sleep disturbance, and menopausal symptoms with diminished libido. STUDY DESIGN:Data from a 2001-2002 baseline survey of 341 peri- and postmenopausal women, aged 45-55 years, participating in a randomized trial, was analyzed. Eligibili...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2007.03.008

    authors： Reed SD,Newton KM,LaCroix AZ,Grothaus LC,Ehrlich K

    更新日期：2007-06-01 00:00:00

  • Obstetric outcomes after surgical abortion at > or = 20 weeks' gestation.

    abstract：OBJECTIVE:The purpose of this study was to describe obstetric outcomes after surgical abortion at > or = 20 weeks, and to identify risk factors for subsequent spontaneous preterm birth. STUDY DESIGN:Patients who had surgical abortion at > or = 20 weeks' gestation from 1996 to 2003 and received subsequent prenatal care...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2005.05.078

    authors： Chasen ST,Kalish RB,Gupta M,Kaufman J,Chervenak FA

    更新日期：2005-09-01 00:00:00

  • Achieving high value in the surgical approach to hysterectomy.

    abstract：:Value-based care, best clinical outcome relative to cost, is a priority in correcting the high costs for average clinical outcomes of health care delivery in the United States. Hysterectomy represents the most common and identifiable nonobstetric major surgical procedure among women. Surgical approaches to hysterectom...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2018.11.124

    authors： Whiteside JL,Kaeser CT,Ridgeway B

    更新日期：2019-03-01 00:00:00

  • Fetal heart rate and survival of the very premature newborn.

    abstract：OBJECTIVE:Our purpose was to study the likelihood of survival of infants who are born before 28 weeks of gestation and to examine the influence of fetal heart rate findings on neonatal death. STUDY DESIGN:In this retrospective study, we analyzed the mortality rate of infants at 2 months of age as a function of various...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1067/mob.2002.126291

    authors： Ayoubi JM,Audibert F,Vial M,Pons JC,Taylor S,Frydman R

    更新日期：2002-10-01 00:00:00

  • Antenatal Down syndrome screening in the United States in 2001: a survey of maternal-fetal medicine specialists.

    abstract：OBJECTIVE:Our objectives were to determine patterns of antenatal Down syndrome screening and risk adjustment by maternal-fetal medicine specialists in the United States in 2001. STUDY DESIGN:A survey to investigate Down syndrome screening practice patterns was mailed to the 1,638 members of the Society of Maternal-Fet...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1067/mob.2002.126980

    authors： Egan JF,Kaminsky LM,DeRoche ME,Barsoom MJ,Borgida AF,Benn PA

    更新日期：2002-11-01 00:00:00

  • Microarray technology in obstetrics and gynecology: a guide for clinicians.

    abstract：:Microarrays can be constructed with dozens to millions of probes on their surface to allow high-throughput analyses of many biologic processes to be performed simultaneously on the same sample. Microarrays are now widely used for gene expression analysis, deoxyribonucleic acid resequencing, single-nucleotide polymorph...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ajog.2005.12.014

    authors： Ward K

    更新日期：2006-08-01 00:00:00

  • Associations of gestational cardiovascular health with pregnancy outcomes: the Hyperglycemia and Adverse Pregnancy Outcome study.

    abstract：BACKGROUND:The American Heart Association's formal characterization of cardiovascular health combines several metrics in a health-oriented, rather than disease-oriented, framework. Although cardiovascular health assessment during pregnancy has been recommended, its significance for pregnancy outcomes is unknown. OBJEC...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2020.07.053

    authors： Perak AM,Lancki N,Kuang A,Labarthe DR,Allen NB,Shah SH,Lowe LP,Grobman WA,Scholtens DM,Lloyd-Jones DM,Lowe WL Jr,Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study Cooperative Research Group.

    更新日期：2020-08-05 00:00:00

  • Vaginal sonography versus serum human chorionic gonadotropin in early detection of pregnancy.

    abstract：:We first performed a vaginosonic scan and then determined the serum human chorionic gonadotropin (beta-hCG) concentration (Second International Standard) in 52 women at an early gestational age to establish criteria for the earliest possible identification of an intrauterine pregnancy by this new ultrasound technique....

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(88)90039-7

    authors： Bernaschek G,Rudelstorfer R,Csaicsich P

    更新日期：1988-03-01 00:00:00

  • Dissection of the cardinal ligament in radical hysterectomy for cervical cancer with emphasis on the lateral ligament.

    abstract：:Surgical experience with carcinomas of the uterus and rectum has provided new insights into the surgical anatomy of a lamina, which separates the paravesical space from the pararectal space. It has been proved that each of the lamina consists of the cardinal and lateral ligaments and pelvic splanchnic nerves, descendi...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(91)90614-w

    authors： Yabuki Y,Asamoto A,Hoshiba T,Nishimoto H,Kitamura S

    更新日期：1991-01-01 00:00:00

  • Clinical guides to preventing ethical conflicts between pregnant women and their physicians.

    abstract：:We provide a justification for preventive ethics in obstetric practice. Four clinical guides to resolving ethical conflicts between pregnant women and their physicians can be identified: (1) informed consent as an ongoing dialogue between the pregnant woman and her physician, (2) negotiation as a clinical strategy, (3...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(90)90374-g

    authors： Chervenak FA,McCullough LB

    更新日期：1990-02-01 00:00:00

  • Natural history of chronic proteinuria complicating pregnancy.

    abstract：OBJECTIVE:Although the significance of proteinuria is well-documented for pregnancy complicated by preeclampsia or diabetes, protein excretion of up to 300 mg per day is considered normal for uncomplicated pregnancy. Our purpose was to determine the significance of otherwise "asymptomatic" proteinuria identified during...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/s0002-9378(11)91692-5

    authors： Stettler RW,Cunningham FG

    更新日期：1992-11-01 00:00:00

  • The obstetrical and neonatal impact of maternal opioid detoxification in pregnancy.

    abstract：OBJECTIVE:The purpose of this study was to analyze the obstetric and neonatal impact of an opioid detoxification program during pregnancy, as well as to examine variables associated with successful opioid detoxification. STUDY DESIGN:This is a retrospective cohort study of women electing inpatient detoxification and s...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2013.05.026

    authors： Stewart RD,Nelson DB,Adhikari EH,McIntire DD,Roberts SW,Dashe JS,Sheffield JS

    更新日期：2013-09-01 00:00:00

  • Studies on the decreased gonadotropin response after administartion of LH-FSH-releasing hormone during pregnancy and the puerperium.

    abstract：:The responsiveness of the pituitary to luteinizing hormone releasing hormone (LRH) during pregnancy and the puerperium was studied in 15 women 18-32 years of age (3 puerperal, 6 pregnant, and 6 eumenorrheic). 25 mcg LRH dissolved in 1 ml sterile water was administered iv to all the subjects. Blood samples were obtai...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(74)90145-8

    authors： Jeppsson S,Rannevik G,Kullander S

    更新日期：1974-12-15 00:00:00

  • Effect of stress during labor on the concentration of cortisol and estriol in maternal plasma.

    abstract：:The effect of stress during labor on the plasma concentration of cortisol, unconjugated estriol, and human chorionic somatomammotropin was studied in 15 healthy primiparous women. According to the method of pain relief the parturients were divided into two groups. One group was given continuous epidural analgesia and ...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(79)90650-1

    authors： Maltau JM,Eielsen OV,Stokke KT

    更新日期：1979-07-15 00:00:00

  • Gestational diabetes mellitus alters maternal and neonatal circulating endothelial progenitor cell subsets.

    abstract：OBJECTIVE:The purpose of this study was to examine whether women with gestational diabetes mellitus (GDM) and their offspring have reduced endothelial progenitor cell subsets and vascular reactivity. STUDY DESIGN:Women with GDM, healthy control subjects, and their infants participated. Maternal blood and cord blood we...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2010.10.913

    authors： Acosta JC,Haas DM,Saha CK,Dimeglio LA,Ingram DA,Haneline LS

    更新日期：2011-03-01 00:00:00

  • Arterial wall hyperplasia is increased in placental compared with myoendometrial radial uterine arteries from late-pregnant rats.

    abstract：OBJECTIVE:This study compared myoendometrial versus placental radial uterine arteries from late-pregnant rats to evaluate differences in passive mechanical properties and arterial wall hyperplasia. STUDY DESIGN:Myoendometrial and placental radial uterine arteries were dissected from late-pregnant (day 17-19) Sprague-D...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2004.06.094

    authors： Hammer ES,Cipolla MJ

    更新日期：2005-01-01 00:00:00

  • Factors that affect the quality of cytologic cervical cancer screening along the Mexico-United States border.

    abstract：OBJECTIVE:The purpose of this study was to identify the factors that affect the quality of cytologic cervical cancer screening conducted in public sector clinics in Sonora, Mexico. STUDY DESIGN:We assessed the quality of cervical cytology before and after a 2-hour training session and the implementation of cervical sp...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1067/s0002-9378(03)00490-3

    authors： Garcia F,Mendez de Galaz E,Baldwin S,Papenfuss M,Giuliano AR,Hatch K,Davis J

    更新日期：2003-08-01 00:00:00

  • Androgen insensitivity syndrome: gonadal androgen receptor activity.

    abstract：:To determine whether abnormalities of the androgen receptor previously observed in skin fibroblasts from patients with androgen insensitivity syndrome also occur in the gonads of affected individuals, androgen receptor activity in the gonads of a patient with testicular feminization syndrome was investigated. Using co...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/s0002-9378(84)90434-4

    authors： Coulam CB,Graham ML 2nd,Spelsberg TC

    更新日期：1984-11-01 00:00:00

  • Increasing NIH funding for academic departments of obstetrics and gynecology: a call to action.

    abstract：:The National Institutes of Health funding for reproductive sciences research, specifically in academic departments of obstetrics and gynecology, is disproportionately low. Research is one of the most important pillars in advancing healthcare. Despite US Congress' vision in providing increased funding to the National I...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2020.03.022

    authors： Rice LW,Cedars MI,Sadovsky Y,Siddiqui NY,Teal SB,Wright JD,Zorbas A,Del Carmen MG

    更新日期：2020-07-01 00:00:00

  • Spontaneous preterm birth: advances toward the discovery of genetic predisposition.

    abstract：:Evidence from family and twin-based studies provide strong support for a significant contribution of maternal and fetal genetics to the timing of parturition and spontaneous preterm birth. However, there has been only modest success in the discovery of genes predisposing to preterm birth, despite increasing sophistica...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ajog.2017.12.009

    authors： Strauss JF 3rd,Romero R,Gomez-Lopez N,Haymond-Thornburg H,Modi BP,Teves ME,Pearson LN,York TP,Schenkein HA

    更新日期：2018-03-01 00:00:00

  • Menstrual cycle-specific inhibition of the proliferation of endometrial stromal cells by interleukin 6 and its soluble receptor.

    abstract：OBJECTIVE:This study investigated the possible roles of interleukin 6 and soluble interleukin 6 receptor in the growth of endometrial and endometriotic cells. STUDY DESIGN:Endometrial and endometriotic stromal cells were collected from the uterus or from ovarian chocolate cysts. We examined the effects of interleukin ...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/s0002-9378(99)70599-5

    authors： Yoshioka H,Harada T,Iwabe T,Nagano Y,Taniguchi F,Tanikawa M,Terakawa N

    更新日期：1999-05-01 00:00:00