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Iron supplementation and gestational diabetes in midpregnancy.

Abstract：

OBJECTIVE:Iron supplementation in pregnancy seems beneficial for neonatal/maternal outcomes, but it was associated with diabetes and hypertension in the general population. STUDY DESIGN:We investigated the association between iron supplementation during midpregnancy and metabolic/hypertensive abnormalities in 500 consecutive gestational diabetes mellitus (GDM) and 500 normoglycemic women. RESULTS:Iron-supplement users (n = 212/1000) showed significantly higher values of prepregnancy body mass index (BMI), actual BMI, waist circumference, blood pressure, fasting glucose, Homeostasis-Model-Assessment-Insulin-Resistance, and lower high-density lipoprotein-cholesterol than nonusers. The prevalence of GDM (70.8% vs 44.4%), hypertension (25.9% vs 9.8%), metabolic syndrome (25.9% vs 10.4%) was significantly higher in the former with a 2- to 3-fold-increased risk at multiple regression analyses. Most glucose values of the oral glucose tolerance test were significantly higher in iron supplemented women, both in GDM and normoglycemic individuals. CONCLUSION:Iron supplementation is associated with glucose impairment and hypertension in midpregnancy; its potential harmful effects might be carefully debated regarding its effectiveness.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Bo S,Menato G,Villois P,Gambino R,Cassader M,Cotrino I,Cavallo-Perin P

doi

10.1016/j.ajog.2009.04.049

subject

Has Abstract

pub_date

2009-08-01 00:00:00

pages

158.e1-6

issue

2

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(09)00443-8

journal_volume

201

pub_type

杂志文章

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