Abstract：
OBJECTIVE:Our objective was to ascertain long-term tolerability and effects of a novel, low-dosage continuous progestin-cyclic estrogen regimen on vasomotor flushing, vaginal bleeding patterns, bone density, and plasma lipoprotein lipids. STUDY DESIGN:Eighteen postmenopausal women with climacteric symptoms received low doses of dl-norgestrel (0.075 mg/day) continuously and 17 beta-estradiol (1 mg/day) intermittently (25 of 28 days) for 3 years. The results were compared with baseline values. RESULTS:The hormonal regimen was well tolerated. Vaginal bleeding, vaginal spotting, and vasomotor flushing occurred in only 0.4%, 4.2%, and 7.7% of cycles, respectively. Bone density was stable. Mean fasting plasma total cholesterol concentration fell 19%, low-density lipoprotein cholesterol 23%, high-density lipoprotein cholesterol 13%, and triglycerides 31% (p less than 0.01) over the 3-year period, while the ratios of low-density lipoprotein cholesterol/high-density lipoprotein cholesterol and total cholesterol/high-density lipoprotein cholesterol decreased by 14% and 10%, respectively. CONCLUSION:Long-term compliance with female hormonal replacement is feasible once vaginal bleeding is essentially eliminated, allowing for potentially better prophylaxis against coronary heart disease, osteoporosis, endometrial cancer, and stroke.
journal_name
Am J Obstet Gynecoljournal_title
American journal of obstetrics and gynecologyauthors
Plunkett ER,Wolfe BMdoi
10.1016/0002-9378(92)91842-xsubject
Has Abstractpub_date
1992-01-01 00:00:00pages
117-21issue
1 Pt 1eissn
0002-9378issn
1097-6868pii
0002-9378(92)91842-Xjournal_volume
166pub_type
杂志文章abstract：:Vulvodynia is chronic vulvar burning/pain without clear medical findings. The etiology of vulvodynia is unknown and health care professionals should thoroughly rule out specific, treatable causes or factors such as dermatoses or group B Streptococcus infections. Vulvodynia is divided into 2 classes: vulvar vestibuliti...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章,评审
doi：10.1067/s0002-9378(03)00790-7
更新日期：2003-09-01 00:00:00
abstract：:Engaging women in discussions about reproductive goals in health care settings is increasingly recognized as an important public health strategy to reduce unintended pregnancy and improve pregnancy outcomes. "Reproductive life planning" has gained visibility as a framework for these discussions, endorsed by public hea...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/j.ajog.2016.10.004
更新日期：2017-02-01 00:00:00
abstract：:Placental mesenchymal dysplasia is a benign condition that can be confused with a molar pregnancy by ultrasound scanning and gross examination. Conservative management should be considered with a normal-appearing singleton fetus and a cystic-appearing placenta. We present a case of placental mesenchymal dysplasia with...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/j.ajog.2011.08.019
更新日期：2011-12-01 00:00:00
abstract：OBJECTIVE:Our purpose was to compare the incidence and interrelationships of uteroplacental vasculopathy and chronic inflammatory and placental vasoocclusive lesions in preeclampsia and spontaneous delivery before 32 weeks' gestation. STUDY DESIGN:Review of singleton live-born nonanomalous infants born at 22 to 32 wee...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/0002-9378(95)91333-5
更新日期：1995-10-01 00:00:00
abstract：:A successful pregnancy in a patient with a 45,X/47,XXX karyotype who had premature menopause is described. Review of the literature revealed an additional 24 cases of fertility in women with gonadal dysgenesis associated with a 45,X chromosomal line. Their reproductive history showed a total of 58 pregnancies. However...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/0002-9378(76)90516-0
更新日期：1976-11-15 00:00:00
abstract：OBJECTIVE:Phosphatase and tensin homolog (PTEN) mutations are associated with human endometrial cancers, and PTEN heterozygote(+/-) mice have a high rate of endometrial neoplasia. The objective of this study was to evaluate an oral mTOR inhibitor (mTOR-I) on the reduction of endometrial hyperplasia in an animal model. ...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/j.ajog.2006.10.872
更新日期：2007-03-01 00:00:00
abstract：OBJECTIVE:This study was undertaken to determine whether the presence of a dilated internal os (funneling or beaking) alters the outcome of patients with a short cervix documented by transvaginal ultrasound in the second trimester. STUDY DESIGN:Between January 1998 and May 2004, all singleton pregnancies with a short ...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/j.ajog.2005.01.076
更新日期：2005-04-01 00:00:00
abstract：OBJECTIVE:Several studies have shown that abnormal intrapartum fetal heart rate patterns are the results from pre-existing fetal brain damage. We evaluated intrapartum fetal heart rate pattern of cytomegalovirus-infected fetuses and correlated the patterns with neurologic outcomes. STUDY DESIGN:Between 1991 and 2001, ...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/j.ajog.2004.03.015
更新日期：2004-10-01 00:00:00
abstract：BACKGROUND:Randomized controlled trials that have assessed the efficacy of cervical pessary to prevent preterm birth in asymptomatic high-risk women have reported conflicting results. OBJECTIVE:To evaluate the efficacy and safety of cervical pessary to prevent preterm birth and adverse perinatal outcomes in asymptomat...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章,meta分析
doi：10.1016/j.ajog.2019.12.266
更新日期：2020-07-01 00:00:00
abstract：OBJECTIVE:The objective of this study was to investigate the occurrence of in utero defecation as a normal function in the human fetus. STUDY DESIGN:The anuses of 240 fetuses were studied sonographically between weeks 15 and 41 of gestation. Fetal defecation was defined as the expulsion of rectal contents through the ...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1067/mob.2003.107
更新日期：2003-01-01 00:00:00
abstract：OBJECTIVE:We sought to determine if periconceptional exposure to agrichemicals was associated with the development of gastroschisis. STUDY DESIGN:We conducted a retrospective, case-controlled study using Washington State Birth Certificate and US Geological Survey databases. Cases included all live-born singleton infan...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/j.ajog.2010.01.023
更新日期：2010-03-01 00:00:00
abstract：:The angiotensin II sensitivity test has been used to predict the development of hypertension during pregnancy. We investigated the systolic/diastolic ratios of flow velocity waveforms in the uterine and umbilical arteries by means of a color Doppler system in 15 healthy women at 24 to 26 weeks' gestation. A significan...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/0002-9378(90)90015-y
更新日期：1990-05-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to determine, with the use of a rat model, the expression of tumor necrosis factor (TNF)-alpha, its receptors, and TNF-alpha-converting enzyme in perinatal brain lesions of early premature neonates. STUDY DESIGN:Lipopolysaccharide (LPS) was injected intraperitoneally in pregnant rat...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/j.ajog.2009.06.005
更新日期：2009-11-01 00:00:00
abstract：OBJECTIVE:Closure of a low transverse cesarean incision with one layer of suture results in less operating time, better hemostasis, and less infectious morbidity than a two-layer closure. STUDY DESIGN:At our institution 906 women were randomized to closure of a low transverse cesarean incision with either one continuo...
journal_title：American journal of obstetrics and gynecology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0002-9378(12)80048-2
更新日期：1992-10-01 00:00:00
abstract：:Leiomyomas most frequently occur in the genitourinary and gastrointestinal system. This report discusses clinical and pathologic findings of 2 leiomyomas in the pubovesical space, a location that has not been described before. Different operative approaches were used for excision. Immunohistochemical examination for t...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1067/mob.2001.114503
更新日期：2001-07-01 00:00:00
abstract：:A 3-year follow-up study was carried out on 20 children examined in utero with echo-planar magnetic resonance imaging when fetal compromise had been demonstrated or was suspected. There was no demonstrable increase in the occurrence of disease or disability (including hearing deficit) that could be related to echo-pla...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/s0002-9378(94)70379-5
更新日期：1994-01-01 00:00:00
abstract：OBJECTIVE:The studies presented in this report were undertaken to evaluate whether Fusobacterium nucleatum, a common anaerobic isolate in intrauterine infection, stimulates arachidonic acid metabolism, a rate-limiting step for prostaglandin synthesis, in the human uterine endometrium. STUDY DESIGN:Effects of F nucleat...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/s0002-9378(98)70028-6
更新日期：1998-12-01 00:00:00
abstract：OBJECTIVE:The purpose of this study was to determine the reported diagnostic accuracy, the validity, and the current limitations of fetal Rh genotyping from peripheral maternal blood based on the existing English-written publications. STUDY DESIGN:A search of the English literature describing fetal RhD determination f...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章,meta分析
doi：10.1016/j.ajog.2006.07.033
更新日期：2006-10-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to evaluate the relationships between maternal vitamin D levels and gestational diabetes mellitus (GDM) and differences in the placental production of vitamin D receptor (VDR), CYP24A, and CYP27B1. STUDY DESIGN:Forty normal pregnant women and 20 women with GDM were included in this ...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/j.ajog.2013.08.015
更新日期：2013-12-01 00:00:00
abstract：OBJECTIVE:The purpose of this study was to evaluate whether maternal febrile illnesses in early pregnancy are associated with increased risk for congenital heart defects in the offspring and whether such risk is mitigated by multivitamin supplement use. STUDY DESIGN:From a multistate population-based case-control stud...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/j.ajog.2013.10.880
更新日期：2014-04-01 00:00:00
abstract：:Scanning electron microscopy was used to study the morphologic characteristics of erythrocytes in women with preeclampsia and eclampsia. In nine nulliparous women with eclampsia, the proportion of abnormal red cells (schistocytes, echinocytes, and spherocytes) was significantly greater than in 12 normally pregnant con...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/0002-9378(85)90071-7
更新日期：1985-10-15 00:00:00
abstract：OBJECTIVE:The purpose of this study was to test the effects of varying the amount of physical practice and mental imagery rehearsal on learning basic surgical procedures. STUDY DESIGN:Using a sample of 65 second-year medical students, 3 randomized groups received either: (1) 3 sessions of physical practice on suturing...
journal_title：American journal of obstetrics and gynecology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.ajog.2004.07.075
更新日期：2004-11-01 00:00:00
abstract：OBJECTIVE:We sought to quantify the gestational age-specific morbidity of black vs white neonates. STUDY DESIGN:This was a population-based retrospective cohort study of singleton live births in Ohio from 2006 through 2007. The primary outcome was a composite of adverse neonatal outcomes of ≥ 1 morbidity: Apgar score ...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/j.ajog.2011.12.017
更新日期：2012-03-01 00:00:00
abstract：:Supernatants from isolated trophoblast cell cultures (trophoblastic fluid) derived from first-trimester human placentas were assessed for immunoregulatory activity. Trophoblastic fluid at different days of culture consistently inhibited the blast transformation of allogenic lymphocytes. This suppressor effect had no a...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/0002-9378(89)90540-1
更新日期：1989-08-01 00:00:00
abstract：:To stimulate first-trimester human cytomegalovirus infection, pregnant guinea pigs were inoculated with a low dose of guinea pig cytomegalovirus during the first trimester of pregnancy. Maternal viremia, which was cleared by 2 weeks after inoculation, was found to reappear near the time of delivery in one third of the...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/0002-9378(87)90159-1
更新日期：1987-05-01 00:00:00
abstract：:Virilization in pregnancy has been reported with various ovarian neoplasms. Presented is a case of maternal virilization resulting from an unclassified sex-cord stromal neoplasm. ...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/0002-9378(85)90627-1
更新日期：1985-07-01 00:00:00
abstract：:Statistical procedures for hypothesis testing and interval estimation of the difference in a pair of Pearl rates are presented. The p value of the test statistic is evaluated exactly from the binomial distribution or approximately from the standard normal distribution. Interval estimation is provided by the test-based...
journal_title：American journal of obstetrics and gynecology
pub_type： 临床试验,杂志文章
doi：10.1016/0002-9378(85)90158-9
更新日期：1985-03-01 00:00:00
abstract：:FloSeal hemostatic matrix has been reported to be effective for the control of intraoperative bleeding in various surgeries. We report 3 patients who experienced a possible allergic response to FloSeal with the formation of excessive granulation tissue and fibrosis that were associated with early postoperative pelvic ...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/j.ajog.2008.10.052
更新日期：2009-04-01 00:00:00
abstract：OBJECTIVE:We evaluated the use of the harmonic scalpel in reducing the occurrence of symptomatic lymphoceles and its related complications in paraaortic laparoscopic lymphadenectomies (PALLs). STUDY DESIGN:All PALL that were performed at the Institut Claudius Regaud between January 2003 and June 2007 were included. Si...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/j.ajog.2009.05.026
更新日期：2009-10-01 00:00:00
abstract：OBJECTIVE:Women who deliver preterm infants may be at increased risk for cardiovascular disease, perhaps related to dyslipidemia. STUDY DESIGN:In a nested case control study of women with spontaneous preterm birth, cholesterol, high-density lipoprotein, low-density lipoprotein, and triglycerides were evaluated. Lipid ...
journal_title：American journal of obstetrics and gynecology
pub_type： 临床试验,杂志文章
doi：10.1016/j.ajog.2007.04.024
更新日期：2007-12-01 00:00:00
