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Agricultural-related chemical exposures, season of conception, and risk of gastroschisis in Washington State.

Abstract：

OBJECTIVE:We sought to determine if periconceptional exposure to agrichemicals was associated with the development of gastroschisis. STUDY DESIGN:We conducted a retrospective, case-controlled study using Washington State Birth Certificate and US Geological Survey databases. Cases included all live-born singleton infants with gastroschisis. Distance between a woman's residence and site of elevated exposure to agrichemicals was calculated. Multivariate regression was used to estimate the association between surface water concentrations of agrichemicals and the risk of gastroschisis. RESULTS:Eight hundred five cases and 3616 control subjects were identified. Gastroschisis occurred more frequently among those who resided <25 km from a site of high atrazine concentration (odds ratio, 1.6). Risk was related inversely to the distance between the maternal residence and the closest toxic atrazine site. In multivariate analysis, nulliparity, tobacco use, and spring conception remained significant predictive factors for gastroschisis. CONCLUSION:Maternal exposure to surface water atrazine is associated with fetal gastroschisis, particularly in spring conceptions.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Waller SA,Paul K,Peterson SE,Hitti JE

doi

10.1016/j.ajog.2010.01.023

subject

Has Abstract

pub_date

2010-03-01 00:00:00

pages

241.e1-6

issue

3

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(10)00034-7

journal_volume

202

pub_type

杂志文章

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