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Estrogen potency of oral contraceptive pills.

Abstract：

:The estrogen potencies of 9 oral contraceptive pills, Enovid-E, Enovid-5, Ovulen, Demulen, Norinyl+80, Norinyl+50, Ovral, Norlestrin 1 mg. and Norlestrin 2.5 mg., were determined by bioassay. Relative estrogen potency was determined by analysis of variance. Enovid-5, the most estrogenic compound, had a potency of 4.88 compared to ethinyl estradiol, 50 mcg. equal 1.00; Ovral, the least estrogenic compound, had a potency of 0.81, a sixfold difference. Estrogen potencies at a fractional dose of 0.00155 correlate with reports of the incidence of minor side effects and thromboembolic disease. The effect of progestins on estrogen potency was purely additive (norgestrel and norethynodrel), purely antagonistic, or additive at low concentrations and antagonistic at high concentrations (norethindrone, norethindrone acetate, and ethynodiol diacetate). These results suggest that pills with a greater margin of safety might be developed by utilizing greater ratios of progestin to estrogen. In addition, differences in relative estrogen potency of oral contraceptive pills may be used as a basis for better clinical selection.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Chihal HJ,Peppler RD,Dickey RP

doi

10.1016/0002-9378(75)90979-5

subject

Has Abstract

pub_date

1975-01-01 00:00:00

pages

75-83

issue

1

eissn

0002-9378

issn

1097-6868

pii

0002-9378(75)90979-5

journal_volume

121

pub_type

杂志文章

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