Photosensitization of the endometrium with topical 5-aminolevulinic acid.

Abstract:

:Photosensitization of the endometrium was attempted in vitro and in vivo by intrauterine administration of 5-aminolevulinic acid, which is converted to the photosensitizer protoporphyrin IX. Protoporphyrin IX was found in both functional and basal layers of the endometrial glands at concentrations nine and 10 times higher than myometrium in in vitro and in vivo experiments, respectively. Selective endometrial photosensitization is possible with topical 5-aminolevulinic acid, but it might not be distributed sufficiently evenly for use as a sensitizing agent in photodynamic ablation.

journal_name

Am J Obstet Gynecol

authors

Gannon MJ,Johnson N,Roberts DJ,Holroyd JA,Vernon DI,Brown SB,Lilford RJ

doi

10.1016/0002-9378(95)90435-2

subject

Has Abstract

pub_date

1995-12-01 00:00:00

pages

1826-8

issue

6

eissn

0002-9378

issn

1097-6868

pii

0002-9378(95)90435-2

journal_volume

173

pub_type

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