Amniotic fluid insulin testing in gestational diabetes: safety and acceptance of amniocentesis.

Abstract:

OBJECTIVES:We analyzed the safety and patient acceptance of amniotic fluid insulin measurements by third-trimester amniocentesis in women with gestational diabetes mellitus. STUDY DESIGN:We studied the rate of early uterine contractions, need for tocolysis, premature rupture of membranes, mode of delivery, length of gestation, and fetal weight and length at birth in 194 women with gestational diabetes mellitus who underwent third-trimester amniocentesis and 268 controls. Patient acceptance of amniocentesis was assessed prospectively with a visual rating scale and a semistructured interview comparing 50 women with gestational diabetes mellitus to 50 women undergoing second-trimester amniocentesis for fetal karyotyping. RESULTS:Only the length of gestation differed significantly but without clinical relevance (39.5 +/- 1.9 vs 40.0 +/- 2.0, P = .006) between women with gestational diabetes mellitus who had amniocentesis and controls. Patient acceptance was equally high both for second-trimester and third-trimester amniocentesis. CONCLUSIONS:Third-trimester amniocentesis for measuring amniotic fluid insulin is safe and well accepted by the patients. This is important information both for treating and counseling women with gestational diabetes mellitus.

journal_name

Am J Obstet Gynecol

authors

Haeusler MC,Konstantiniuk P,Dorfer M,Weiss PA

doi

10.1016/s0002-9378(98)70221-2

subject

Has Abstract

pub_date

1998-10-01 00:00:00

pages

917-20

issue

4

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(98)70221-2

journal_volume

179

pub_type

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