Platelet monoamine oxidase B activity in women with premenstrual syndrome.

Abstract:

:Several lines of evidence suggest a strong association between premenstrual syndrome and affective disorder. Similar psychological symptoms, behavioral manifestations, and biochemical etiologies have been reported. We attempted to evaluate the biologic interconnection between premenstrual syndrome and psychiatric disorder by investigating the platelet enzyme, monoamine oxidase B. The activity of this enzyme has been noted to be decreased in affective disorder, alcoholism, and psychiatric vulnerability. Platelet monoamine oxidase B activity, estradiol, and progesterone were assessed throughout one menstrual cycle in 13 women with premenstrual syndrome and 19 control subjects. No significant differences were noted between groups using these parameters. The study indicates that well-screened subjects with premenstrual syndrome are, as evidenced by the parameter of monoamine oxidase B, biochemically similar to normal control subjects.

journal_name

Am J Obstet Gynecol

authors

Rapkin AJ,Buckman TD,Sutphin MS,Chang LC,Reading AE

doi

10.1016/0002-9378(88)90590-x

subject

Has Abstract

pub_date

1988-12-01 00:00:00

pages

1536-40

issue

6

eissn

0002-9378

issn

1097-6868

pii

0002-9378(88)90590-X

journal_volume

159

pub_type

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