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Congenital limb reduction deformities and use of oral contraceptives.

Abstract：

:A study of congenital limb deficiencies in two Australian states indicated that use of an oral contraceptive during pregnancy by the mother was associated with an increased risk of limb defect in the child. The study included mothers of 155 children born with absence or reduction of the major long bones during a 12-year period from 1970 onward; 274 mothers with births of normal infants, matched for date of birth and area of residence, made up the control group. Compared with control infants, the case infants were more likely to have been conceived while the mother was using an oral contraceptive, especially when the deformity was a transverse or amputation type. It is too early in our state of knowledge of teratogenic mechanisms to exclude the possible existence of a biologic mechanism that would explain this statistical association. :A study of congenital limb deficiencies in 2 Australian states indicate that use of an oral contraceptive during pregnancy by the mother was associated with an increased risk of limb defect in the child. The study included mothers of 155 children born with absence or reduction of the major long bones during a 12-year period from 1970 onward; 274 mothers with births of normal infants, matched for date of birth and area of residence, made up the control group. Detailed results are presented, including a multivariate analysis that incorporated as potential confounders maternal age, sex of infant, parity of mother, staus of father's occupation, and a number of pregnancy factors. Each mother was interviewed an average of 405 years after the birth of the child. Compared with control infants, the case infants were more likely to have been conceived while the mother was using an oral contraceptive, particularly when the deformity was a transverse or amputation type. Knowledge of teratogenic mechanisms is not advanced enough to enable exclusion of the possible existence of a biologic mechanism that would explain this statistical assocation. Low socioeconomic status judged by an unskilled occupation of the father, sex of the child (male), vaginal bleeding at any time during pregnancy, and a febrile illness in the 1st trimester were significant at the 0.05 level, while smoking during pregnancy, hormonal therapy, maternal age, and parity were mot.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Kricker A,Elliott JW,Forrest JM,McCredie J

doi

10.1016/0002-9378(86)90352-2

subject

Has Abstract

pub_date

1986-11-01 00:00:00

pages

1072-8

issue

eissn

0002-9378

issn

1097-6868

pii

0002-9378(86)90352-2

journal_volume

155

pub_type

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Congenital limb reduction deformities and use of oral contraceptives.