当前位置： SCI文献检索 > AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY期刊下所有文献 > Localized increase in nitric oxide production and the expression of nitric oxide synthase isoforms in rat uterus with experimental intrauterine infection.

Localized increase in nitric oxide production and the expression of nitric oxide synthase isoforms in rat uterus with experimental intrauterine infection.

Abstract：

OBJECTIVE:We recently reported that nitric oxide was associated with increased mortality among pregnant rats with intrauterine infection. In our current study we investigated the expression of different isoforms of nitric oxide synthases and nitric oxide in the nonpregnant rat uterus with experimental intrauterine infection. STUDY DESIGN:Pathogenic Escherichia coli was inoculated into the uterine lumen of ovariectomized rats. Animals were killed after inoculation, and uterine horns were collected for assessing nitric oxide production with high-performance liquid chromatography and nitric oxide synthase (type II and type III) protein expression with Western immunoblotting and immunofluorescence methods. RESULTS:(1) Nitric oxide production increased in the infected uterine horn in a time-dependent manner after intrauterine infection but did not increase in the uninfected horn. (2) Nitric oxide synthase type III protein contents did not show a difference between infected and uninfected horns, and type III nitric oxide synthase was expressed by the epithelial cells and smooth muscle cells. (3) Type II nitric oxide synthase was abundantly expressed in infected horns but was not expressed in uninfected horns. Immunofluorescence data indicated that macrophages and natural killer cells, located in the endometrial layer clustering around epithelial cells, expressed type II protein. CONCLUSION:We suggest that localized increase in type II nitric oxide synthase expression and nitric oxide production occurs in response to intrauterine infection and that the nitric oxide system may play a role in host response to restrict the infection.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Fang L,Nowicki BJ,Dong YL,Yallampalli C

doi

10.1016/s0002-9378(99)70499-0

subject

Has Abstract

pub_date

1999-09-01 00:00:00

pages

601-9

issue

3

eissn

0002-9378

issn

1097-6868

pii

S0002937899704990

journal_volume

181

pub_type

杂志文章

相关文献

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY文献大全
  • Persistent pulmonary hypertension in the neonate: development of an animal model.

    abstract：:Chronic intrauterine hypoxia was induced in third-trimester lamb fetuses by daily embolization of the maternal side of the placenta with nonradioactive microspheres. After delivery at term, the chronically hypoxic fetuses had significantly increased pulmonary artery pressures when compared to nonhypoxic control measur...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(78)90242-9

    authors： Drummond WH,Bissonnette JM

    更新日期：1978-08-01 00:00:00

  • Mid-trimester abortion induced by intravaginal administration of prostaglandin E2 suppositories.

    abstract：:Mid-trimester abortion was successfully induced in 70 of 71 patients by administration of vaginal PGE2 suppositories. The one patient who failed to abort with this method was pregnant in the blind horn of a duplex uterus. The mean abortion time for the successful inductions was 11.88 hours. Multiparous patients aborte...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(75)90353-1

    authors： Lauersen NH,Secher NJ,Wilson KH

    更新日期：1975-08-15 00:00:00

  • Bilateral hematosalpinx in a case of ectopic pregnancy: a clinical dilemma.

    abstract：:A 31-year-old woman with a positive pregnancy test and a transvaginal ultrasound scan result that was suggestive of a right tubal ectopic pregnancy underwent a laparoscopy, which showed bilateral hematosalpinx. In the presence of active bleeding and deteriorating hemodynamic status of the patient, a minilaparotomy was...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1067/s0002-9378(03)00206-0

    authors： Sindos M,Wang TF,Pisal N,Eben F,Singer A

    更新日期：2003-09-01 00:00:00

  • Possible role of mast cells in the mechanism of action of intrauterine contraceptive devices.

    abstract：:The presence and number of mast cells and their relationship to other inflammatory cells were investigated in smears from intrauterine contraceptive devices. The results obtained suggest a possible role of mast cells in the mechanism of action of intrauterine contraceptive devices, on the basis of the peculiar known f...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/s0002-9378(84)90446-0

    authors： Tursi A,Mastrorilli A,Ribatti D,Loiudice L,Contino R,Claudatus J

    更新日期：1984-04-15 00:00:00

  • Production and origin of estrogen in two true hermaphrodites.

    abstract：:Two 46,XX true hermaphrodites with genital ambiguity since birth and gynecomastia were studied. The production rates of estradiol in these subjects, 77 and 71 microgram per 24 hours, and of estrone, 82 and 136 microgram per 24 hours, were approximately twice those of normal adult men. In one of these subjects the plas...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(78)90775-5

    authors： Aiman J,Hemsell DL,MacDonald PC

    更新日期：1978-10-15 00:00:00

  • Preterm premature rupture of membranes: results of expectant management in patients with cervical cultures positive for group B streptococcus or Neisseria gonorrhoeae.

    abstract：OBJECTIVE:The antepartum course and short-term neonatal outcome for patients with premature rupture of membranes between 26 and 33 weeks' gestation with positive cervical cultures for group B streptococcus or Neisseria gonorrhoeae were reviewed. STUDY DESIGN:A retrospective analysis of 182 patients managed expectantly...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(92)91369-l

    authors： Maxwell GL,Watson WJ

    更新日期：1992-03-01 00:00:00

  • Induction of labor with mifepristone (RU 486) in intrauterine fetal death.

    abstract：:In a double-blind controlled multicentric study involving 94 patients with an intrauterine fetal death, we investigated the efficacy and tolerance of mifepristone (RU 486), a steroid compound that antagonizes progesterone action at the receptor level. Success of treatment was defined as the occurrence of fetal expulsi...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1016/0002-9378(90)91193-g

    authors： Cabrol D,Dubois C,Cronje H,Gonnet JM,Guillot M,Maria B,Moodley J,Oury JF,Thoulon JM,Treisser A

    更新日期：1990-08-01 00:00:00

  • The paradoxical effect of smoking in preeclamptic pregnancies: smoking reduces the incidence but increases the rates of perinatal mortality, abruptio placentae, and intrauterine growth restriction.

    abstract：OBJECTIVES:Smoking is associated with a reduced risk of preeclampsia, but what is the outcome of pregnancy when preeclampsia develops in women who smoke? STUDY DESIGN:Single births in Sweden from 1987 through 1993 to nulliparous women aged 15 to 34 years (N = 317,652) were included. Poisson regression analyses were us...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/s0002-9378(97)70455-1

    authors： Cnattingius S,Mills JL,Yuen J,Eriksson O,Salonen H

    更新日期：1997-07-01 00:00:00

  • The enhanced production of placental interleukin-1 during labor and intrauterine infection.

    abstract：:The purpose of this study was to determine the effect of labor and chorioamnionitis in interleukin-1 production by human placenta. We studied the activity of the placenta to produce interleukin-1 with an enzyme immunoassay by culturing tissue blocks. The placental tissue obtained after labor produced a larger amount o...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(91)90241-i

    authors： Taniguchi T,Matsuzaki N,Kameda T,Shimoya K,Jo T,Saji F,Tanizawa O

    更新日期：1991-07-01 00:00:00

  • Amniotic fluid intercellular adhesion molecule-1 is a marker for Ureaplasma infection in women with preterm labor.

    abstract：OBJECTIVE:The objective of the study was to determine the amniotic fluid soluble intercellular adhesion molecule-1 concentrations in women with preterm labor in relation to intra-amniotic infection. STUDY DESIGN:Amniotic fluids from 125 women with preterm labor (78 with preterm delivery and 47 with term deliveries) we...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2006.05.020

    authors： Hadar A,Ytzhaki O,Shani-Shrem N,Horowitz S,Mazor M,Horowitz S

    更新日期：2006-12-01 00:00:00

  • A novel method for the detection of Down syndrome with the use of four serum markers.

    abstract：OBJECTIVE:The purpose of this study was to evaluate the use of the Lens culinaris agglutinin-reactive alpha-fetoprotein ratio for the detection of fetal Down syndrome in combination with traditional serum markers. STUDY DESIGN:We obtained maternal serum from 530 women with unaffected pregnancies and 31 women who were ...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1067/mob.2002.123201

    authors： Azuma M,Yamamoto R,Wakui Y,Minobe S,Satomura S,Fujimoto S

    更新日期：2002-07-01 00:00:00

  • Estrogen increases inducible nitric oxide synthase gene expression.

    abstract：OBJECTIVE:The goal of this study was to determine whether estrogen increases the expression of the inducible nitric oxide synthase gene. STUDY DESIGN:An inducible nitric oxide synthase fusion gene was created with its promoter and the reporter gene, luciferase. COS cells were transfected transiently with the fusion ge...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1067/mob.2003.350

    authors： Walsh LS,Ollendorff A,Mershon JL

    更新日期：2003-05-01 00:00:00

  • Comparison of bony dimensions at the level of the pelvic floor in women with and without pelvic organ prolapse.

    abstract：OBJECTIVE:We sought to compare bony pelvis dimensions at the level of pelvic support in women with and without pelvic organ prolapse (POP). STUDY DESIGN:Pelvic floor dimensions of 42 white women with POP > 1 cm beyond the hymen were compared with 42 age- and parity-matched women with normal support. Bony landmarks rel...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2008.10.040

    authors： Stein TA,Kaur G,Summers A,Larson KA,DeLancey JO

    更新日期：2009-03-01 00:00:00

  • National patterns of care and fertility outcomes for reproductive-aged women with endometrial cancer or atypical hyperplasia.

    abstract：BACKGROUND:Although it is uncommon, the incidence of endometrial cancer and atypical hyperplasia among reproductive-aged women is increasing. The fertility outcomes in this population are not well described. OBJECTIVE:We aim to describe the patterns of care and fertility outcomes of reproductive-aged women with endome...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2019.05.029

    authors： Harrison RF,He W,Fu S,Zhao H,Sun CC,Suidan RS,Woodard TL,Rauh-Hain JA,Westin SN,Giordano SH,Meyer LA

    更新日期：2019-11-01 00:00:00

  • Multiple gestations from in vitro fertilization: successful implantation alone is not associated with subsequent preeclampsia.

    abstract：OBJECTIVE:Our purpose was to compare the risk for preeclampsia and severe preeclampsia in triplet and twin gestations and to evaluate the effect of successful implantation on the development of preeclampsia and on perinatal outcome in triplet pregnancies conceived by means of in vitro fertilization. STUDY DESIGN:A cas...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/s0002-9378(96)80047-0

    authors： Skupski DW,Nelson S,Kowalik A,Polaneczky M,Smith-Levitin M,Hutson JM,Rosenwaks Z

    更新日期：1996-10-01 00:00:00

  • The relationship between perineal cosmetic talc usage and ovarian talc particle burden.

    abstract：OBJECTIVE:Epidemiologic studies support the hypothesis of a dose-related risk of epithelial ovarian cancer with perineal talc usage exposure. Frequency and duration of talc has not been previously correlated with ovarian talc content. STUDY DESIGN:Ovaries were studied from 24 women undergoing incidental oophorectomy w...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/s0002-9378(96)70597-5

    authors： Heller DS,Westhoff C,Gordon RE,Katz N

    更新日期：1996-05-01 00:00:00

  • Threshold of metabolic acidosis associated with newborn complications.

    abstract：OBJECTIVE:Our purpose was to determine the threshold of metabolic acidosis at delivery associated with newborn complications. STUDY DESIGN:This study was a matched case-control study of 174 term newborn infants. Three groups defined by umbilical artery base deficit at birth were 4 to 8 mmol/L, 8 to 12 mmol/L, and 12 t...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/s0002-9378(97)70080-2

    authors： Low JA,Lindsay BG,Derrick EJ

    更新日期：1997-12-01 00:00:00

  • Squamous cell carcinoma of the vagina following hysterectomy.

    abstract：:A retrospective analysis of 29 cases of squamous cell neoplasia of the vagina following hysterectomy is presented. Two groups of patients were identified; the first presented following hysterectomy for cervical dysplasia or neoplasia on an average of 5.7 years later, and the second presented following hysterectomy for...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(81)90016-8

    authors： Stuart GC,Allen HH,Anderson RJ

    更新日期：1981-02-01 00:00:00

  • Factors that predict low hematocrit levels in the postpartum patient after vaginal delivery.

    abstract：OBJECTIVE:The purpose of this study was to provide a viable alternative to routine postpartum hematocrit measurement, by a determination of the clinical risk factors that identify patients with anemia and an examination of the resulting cost savings. STUDY DESIGN:In this retrospective review, cases (postpartum hematoc...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1067/mob.2002.121255

    authors： Petersen LA,Lindner DS,Kleiber CM,Zimmerman MB,Hinton AT,Yankowitz J

    更新日期：2002-04-01 00:00:00

  • Objectivized diagnosis of acute pelvic inflammatory disease. Diagnostic and prognostic value of routine laparoscopy.

    abstract：:At the University Hospital, Lund, Sweden, laparoscopy has been routinely used as a diagnostic aid in cases for acute pelvic inflammatory disease since 1960. No significant complications have been encountered. The material of the study comprises 905 cases covering an 8 year period, 1960-1967. The operation was alway...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(69)90132-x

    authors： Jacobson L,Weström L

    更新日期：1969-12-01 00:00:00

  • Leiomyoma of the ovary with ascites and hydrothorax.

    abstract：:A case is described in which a leiomyoma of the ovary was accompanied by hydrothorax. There was no reaccumulation of fluid after oophorectomy. ...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(89)90260-3

    authors： Nicoll JJ,Cox PJ

    更新日期：1989-07-01 00:00:00

  • Peroxide induces vasoconstriction in the human placenta by stimulating thromboxane.

    abstract：OBJECTIVE:Placental lipid peroxides and thromboxane are abnormally increased in preeclampsia. Thromboxane is a potent vasoconstrictor of the placental vasculature. Peroxides stimulate cyclooxygenase (prostaglandin H synthase), and thereby could increase thromboxane, to cause vasoconstriction in the placenta. This study...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(93)90044-j

    authors： Walsh SW,Wang Y,Jesse R

    更新日期：1993-10-01 00:00:00

  • Clinical, biochemical, and radiologic reversibility of hyperprolactinemic galactorrhea-amenorrhea and abnormal sella by thyroxine in a patient with primary hypothyroidism.

    abstract：:A case of primary hypothyroidism associated with postpartum galactorrhea-amenorrhea is reported. The configuration of the sella was compatible with pituitary adenoma, but prolactin dynamics did not support an autonomous secretory state. Replacement therapy with thyroxine led to complete reversal of clinical, radiologi...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/s0002-9378(16)33129-5

    authors： Tolis G,Hoyte K,McKenzie JM,Mason B,Robb P

    更新日期：1978-08-15 00:00:00

  • Universal maternal cervical length screening during the second trimester: pros and cons of a strategy to identify women at risk of spontaneous preterm delivery.

    abstract：:Three large randomized controlled trials investigating the efficacy of universal cervical length screening and treatment with vaginal progesterone or cervical cerclage to prevent preterm delivery have been published over the past several years. None of these trials demonstrate proven efficacy for universal cervical le...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2012.04.021

    authors： Parry S,Simhan H,Elovitz M,Iams J

    更新日期：2012-08-01 00:00:00

  • Danazol: endocrine pharmacology and therapeutic applications.

    abstract：:The options for the medical management of endometriosis have been expanded by the introduction of the synthetic steroid, danazol. The results of large clinical studies suggest that danazol treatment produces significant improvement in the symptoms, signs, and laparoscopic findings of endometriosis. The original studie...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章,评审

    doi：10.1016/0002-9378(81)90611-6

    authors： Barbieri RL,Ryan KJ

    更新日期：1981-10-15 00:00:00

  • Prostaglandins and abortion. II. Single extra-amniotic administration of 0.92 mg. of 15-methyl prostaglandin F2alpha in Hyskon for termination of pregnancies in weeks 10 to 20 of gestation: an international multicenter study. World Health Organization Tas

    abstract：:In a multicenter comparative trial, 15-methyl prostaglandin F2alpha(PGF2alpha), 0.92 mg., was administered by extra-amniotic injection to 660 patients. Abortion of the fetus occurred within 24 hours in 479 patients (72.6 per cent) and within 36 hours in 530 patient (80.3 per cent). Abortion was complete in 31 per cent...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：

    authors：

    更新日期：1977-11-15 00:00:00

  • Neonatal mortality in the United States is related to location of birth (hospital versus home) rather than the type of birth attendant.

    abstract：BACKGROUND:Planned home births have leveled off in the United States in recent years after a significant rise starting in the mid-2000s. Planned home births in the United States are associated with increased patient-risk profiles. Multiple studies concluded that, compared with hospital births, absolute and relative ris...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2020.01.045

    authors： Grünebaum A,McCullough LB,Orosz B,Chervenak FA

    更新日期：2020-08-01 00:00:00

  • Acute genital injury in the prepubertal girl.

    abstract：:In an effort to develop guidelines for the management of acute genital injuries in prepubertal girls, we categorized 32 cases by the object that allegedly caused the injury: straddle injuries, nonpenetrating injuries, penetrating injuries, and torque injuries. Using these categories and the anatomic features of symmet...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(92)91620-p

    authors： Pokorny SF,Pokorny WJ,Kramer W

    更新日期：1992-05-01 00:00:00

  • Delayed uterine re-inversion: a unique symptom complex.

    abstract：:A case of late recurrence of uterine inversion is presented. Symptoms included constipation and urinary retention without uterine bleeding. Symptoms resolved 3 months after the replacement of the uterus. It is hypothesized that the symptoms were related to stretch injury to the pelvic parasympathetic nerves. Timely in...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2004.03.027

    authors： Silver DF,Heyl PS,Linfert JB

    更新日期：2004-07-01 00:00:00

  • Epidemiology of miscarriage and its relation to other reproductive events in Finland.

    abstract：OBJECTIVE:This study investigates the occurrence of miscarriages over the reproductive life span of women in a population-based study. STUDY DESIGN:A questionnaire was sent in 1994 to a random sample of 3000 Finnish women aged 18 to 44 years (73% response rate). Age-adjusted percentages of women having had miscarriage...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/s0002-9378(99)70568-5

    authors： Hemminki E,Forssas E

    更新日期：1999-08-01 00:00:00