Antinociceptive and antiedematogenic activities of andrographolide isolated from Andrographis paniculata in animal models.

Abstract:

:The current study was performed to evaluate the antinociceptive and antiedematogenic properties of andrographolide isolated from the leaves of Andrographis paniculata using two animal models. Antinociceptive activity was evaluated using the acetic acid- induced writhing and the hot-plate tests, while antiedematogenic activity was measured using the carrageenan-induced paw edema test. Subcutaneous (s.c.) administration of andrographolide (10, 25, and 50 mg/kg) did not affect the motor coordination of the experimental animals but produced significant (p < .05) antinociceptive activity when assessed using both tests. However, 2 mg/kg naloxone failed to affect the 25 mg/kg andrographolide activity in both tests, indicating that the activity was modulated via nonopioid mechanisms. Furthermore, andrographolide showed significant (p < .05) antiedematogenic activity. In conclusion, the results obtained suggest that andrographolide has antinociceptive and antiedematogenic activities; it may be useful for treating pain and inflammation once human studies are conducted.

journal_name

Biol Res Nurs

authors

Sulaiman MR,Zakaria ZA,Abdul Rahman A,Mohamad AS,Desa MN,Stanslas J,Moin S,Israf DA

doi

10.1177/1099800409343311

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

293-301

issue

3

eissn

1099-8004

issn

1552-4175

pii

1099800409343311

journal_volume

11

pub_type

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