Abstract:
:The current study was performed to evaluate the antinociceptive and antiedematogenic properties of andrographolide isolated from the leaves of Andrographis paniculata using two animal models. Antinociceptive activity was evaluated using the acetic acid- induced writhing and the hot-plate tests, while antiedematogenic activity was measured using the carrageenan-induced paw edema test. Subcutaneous (s.c.) administration of andrographolide (10, 25, and 50 mg/kg) did not affect the motor coordination of the experimental animals but produced significant (p < .05) antinociceptive activity when assessed using both tests. However, 2 mg/kg naloxone failed to affect the 25 mg/kg andrographolide activity in both tests, indicating that the activity was modulated via nonopioid mechanisms. Furthermore, andrographolide showed significant (p < .05) antiedematogenic activity. In conclusion, the results obtained suggest that andrographolide has antinociceptive and antiedematogenic activities; it may be useful for treating pain and inflammation once human studies are conducted.
journal_name
Biol Res Nursjournal_title
Biological research for nursingauthors
Sulaiman MR,Zakaria ZA,Abdul Rahman A,Mohamad AS,Desa MN,Stanslas J,Moin S,Israf DAdoi
10.1177/1099800409343311subject
Has Abstractpub_date
2010-01-01 00:00:00pages
293-301issue
3eissn
1099-8004issn
1552-4175pii
1099800409343311journal_volume
11pub_type
杂志文章abstract::People with schizophrenia have a higher prevalence of obesity than the general population. Many people with this illness struggle with weight gain, due, in part, to medications and other factors that act as obstacles to exercise and healthy eating. Several studies have shown the benefits of behavioral weight loss prog...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800410393272
更新日期:2011-10-01 00:00:00
abstract:PURPOSE:In recent years, researchers have noted an "obesity paradox," where individuals with obesity survive sepsis at higher rates than their nonobese counterparts. This systematic review summarizes the literature on studies examining the association between obesity and 1-year mortality among patients admitted with se...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800419876070
更新日期:2020-01-01 00:00:00
abstract::Cancer-related fatigue (CRF) is a multifactorial, biobehavioral phenomenon experienced by the majority of persons with cancer. It has negative consequences on the individual's physical functioning and quality of life. An array of biological, psychobehavioral, and functional mechanisms contributes to its occurrence. A ...
journal_title:Biological research for nursing
pub_type: 杂志文章,评审
doi:10.1177/1099800408324431
更新日期:2009-04-01 00:00:00
abstract:RESULTS:hs-CRP correlated significantly with SLEDAI-2K (p = .036), SDI (p = .00), anti-dsDNA titers (p = .034), diabetes (p = .005), and obesity (p = .027). hs-CRP and Hcy correlated with triglyceride (TG) levels (p = .032 and p < .001, respectively), TG/high-density lipoprotein cholesterol index (p = .020 and p = .001...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800419889192
更新日期:2020-04-01 00:00:00
abstract::Delirium is a serious complication of acute illness. Little is known, however, regarding the neurobiology of delirium, largely due to challenges in studying the complex inpatient population. Neuroimaging is one noninvasive method that can be used to study structural and functional brain abnormalities associated with d...
journal_title:Biological research for nursing
pub_type: 杂志文章,评审
doi:10.1177/1099800419849489
更新日期:2019-07-01 00:00:00
abstract:OBJECTIVE:We examined genomic variation potentially associated with the cortisol stress response in children having a painful medical procedure. DESIGN:Children 4-10 years old having a peripheral intravenous line inserted provided saliva samples for evaluation of the cortisol response as a biological measure of distre...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800419826315
更新日期:2019-03-01 00:00:00
abstract::Society has a rapidly growing accumulative sleep debt due to employment obligations and lifestyle choices that limit sleep opportunities. The degree to which poor sleep may set the stage for adverse symptom outcomes among more than 1.7 million persons who will be diagnosed with cancer is not entirely understood. Pacli...
journal_title:Biological research for nursing
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doi:10.1177/1099800414539385
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:Depression and inflammation are concomitantly elevated in patients with lung cancer and may have collective survival implications. However, the longitudinal relationship between depression and inflammation in patients with metastatic lung cancer is not fully appreciated. We hypothesized that longitudinal cha...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800420959721
更新日期:2020-09-22 00:00:00
abstract::Age-related changes in skeletal muscle, in combination with bed rest, may result in a poorer rehabilitation potential for an elderly patient. The purpose of this study was to determine the effects of non-weight bearing (hind limb unweighting [HU]) on the soleus and extensor digitorum longus (EDL) in older rats. Two no...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800403260693
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:There are documented associations between elevated maternal corticotropin-releasing hormone (CRH) levels and adverse pregnancy outcomes. However, reports of these findings often lack sufficient detail and rationale regarding the bioassay methodology. This shortcoming can be problematic for researchers who do...
journal_title:Biological research for nursing
pub_type: 杂志文章,评审
doi:10.1177/1099800408320970
更新日期:2008-07-01 00:00:00
abstract:BACKGROUND:Eating disorders are a significant cause of morbidity and mortality. The etiology and maintenance of eating-disorder symptoms are not well understood. Evidence suggests that there may be gustatory alterations in patients with eating disorders. OBJECTIVE:This article systematically reviews research assessing...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800419872824
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:The sacral skin of bedridden older patients often develops a dysbiotic condition. To clarify whether the condition changes or is sustained over time, we analyzed the skin microbiome and the skin physiological functions of the sacral skin in patients who completed our 2017 study. METHODS:In 2019, we collected...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800420941151
更新日期:2021-01-01 00:00:00
abstract::Self-management programs that include cognitive behavioral strategies have been shown to improve gastrointestinal (GI) symptoms, psychological distress, and quality of life (QoL) in persons with irritable bowel syndrome (IBS). However, less is known about the physiological impact of such a change. As part of a randomi...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800411414047
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:This study examined adherence to a personalized, community-based exercise intervention by sedentary adolescents with type 1 or type 2 diabetes or those with obesity. RESEARCH DESIGN AND METHODS:We conducted a pretest-posttest investigation to explore the application of an individualized exercise prescription...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800413500064
更新日期:2014-01-01 00:00:00
abstract::The psychophysiological phenomenon of pain is of tremendous concern to nurses because of its potential to adversely affect the mental, emotional, and physical health of patients. Increasingly appreciated is the ability of pain to influence immune variables including enumerative and functional measures of leukocyte sub...
journal_title:Biological research for nursing
pub_type: 杂志文章,评审
doi:10.1177/1099800405286071
更新日期:2006-04-01 00:00:00
abstract:OBJECTIVE:To investigate associations between components of cumulative risk (CR) and physiological stress responses in African American adolescents and evaluate emotion regulation as a mediator and sex as a moderator of these associations. METHODS:Cortisol and salivary alpha amylase (sAA) were collected in adolescents...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800417702742
更新日期:2017-07-01 00:00:00
abstract::The purpose of this study was to longitudinally describe changes in heart rate variability (HRV) from 28 to 34 weeks postmenstrual age (PMA). A convenience sample of 31 low-risk preterm infants participated. HRV was quantified using a spectral analysis of heart periods and recorded during seven weekly test sessions fr...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800409341175
更新日期:2010-01-01 00:00:00
abstract::The purpose of this study was to compare physiological and psychological reactions among Taiwanese women with different degrees of severity of nausea and vomiting (NV) during pregnancy. Based on their scores on the Index of Nausea, Vomiting, and Retching (INVR), 59 pregnant women ≥ 18 years of age, with single gestati...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800410388506
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVES:To explore whether newborns born via Cesarean section have a weaker intraoral vacuum compared with those born vaginally and to determine whether a weaker intraoral vacuum is related to a delayed onset of lactation. METHODS:For this prospective cohort study, 71 mother-infant dyads were enrolled and divided i...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800416636687
更新日期:2016-07-01 00:00:00
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journal_title:Biological research for nursing
pub_type: 杂志文章,随机对照试验
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更新日期:2016-05-01 00:00:00
abstract::Over the last 10 years, interest in the analysis of saliva as a biomarker for a variety of systemic diseases or for potential disease has soared. There are numerous advantages to using saliva as a biological fluid, particularly for nurse researchers working with vulnerable populations, such as frail older adults. Most...
journal_title:Biological research for nursing
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doi:10.1177/1099800411404211
更新日期:2011-07-01 00:00:00
abstract::Adolescence is considered a critical period for risk of depressive symptoms, with prevalence ranging from 13% to 34%. Few studies have examined the relationships among perceived stress, bullying, and depressive symptoms accompanied by a biological marker of stress (cortisol). The purpose of this pilot study was to det...
journal_title:Biological research for nursing
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更新日期:2017-01-01 00:00:00
abstract::The purpose of this study was to evaluate for differences in variations in pro- and anti-inflammatory cytokine genes between participants who were classified as having low and high levels of morning and evening fatigue and to evaluate for differences in phenotypic characteristics between these two groups. In a sample ...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800414534313
更新日期:2015-03-01 00:00:00
abstract::Depression increases the risk of adverse cardiac events. Cardiovascular reactivity is defined as the pattern of cardiovascular responses to mental stress. An altered pattern of cardiovascular reactivity is an indicator of subsequent cardiovascular disease. Because depression and adverse cardiac events may have a dose-...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800415596227
更新日期:2016-03-01 00:00:00
abstract::Maternal posturing, in which a pregnant or laboring woman assumes specific postures with the intention of altering the position and/or presentation of the fetus within the uterus, is a safe alternative to operative procedures recommended in cases of fetal malpositions and malpresentations. Clinicians and researchers a...
journal_title:Biological research for nursing
pub_type: 杂志文章,评审
doi:10.1177/1099800404268318
更新日期:2004-10-01 00:00:00
abstract:OBJECTIVE:Although the roles of testosterone and cortisol in various health problems have been extensively investigated, little is known about their associations with health outcomes in mothers and their very-low-birthweight (VLBW) infants when maternal testosterone and cortisol are examined together during the postpar...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800417703704
更新日期:2017-07-01 00:00:00
abstract::Central nervous system (CNS)-directed treatment for acute lymphoblastic leukemia, used to prevent disease recurrence in the brain, is essential for survival. Systemic and intrathecal methotrexate, commonly used for CNS-directed treatment, have been associated with cognitive problems during and after treatment. The cor...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800416644780
更新日期:2016-10-01 00:00:00
abstract::Night-shift workers are prone to sleep deprivation, misalignment of circadian rhythms, and subsequent sleepiness and sleep-related performance deficits. The purpose of this narrative systematic review is to critically review and synthesize the scientific literature regarding improvements in sleepiness and sleep-relate...
journal_title:Biological research for nursing
pub_type: 杂志文章,评审
doi:10.1177/1099800413476571
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:Leptin and adiponectin, two adipokines involved in glucose and lipid metabolism, have been linked to regulation of growth in early infancy, energy balance, and metabolic disorders in childhood. The aim of this study was to determine if concentrations of leptin and adiponectin could be measured reliably in in...
journal_title:Biological research for nursing
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更新日期:2020-11-28 00:00:00
abstract::The effects of a 12-week low-intensity exercise conditioning program (walking) on blood pressure (BP), heart rate (HR), rate-pressure product (RPP), and cardiac autonomic function were measured in 40 sedentary women with hypertension. Women were assigned to either an exercise group (n = 20) or a control group (n = 20)...
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更新日期:2013-10-01 00:00:00