Abstract:
:The purpose of this study was to evaluate for differences in variations in pro- and anti-inflammatory cytokine genes between participants who were classified as having low and high levels of morning and evening fatigue and to evaluate for differences in phenotypic characteristics between these two groups. In a sample of 167 oncology outpatients with breast, prostate, lung, or brain cancer and 85 of their family caregivers, growth mixture modeling was used to identify latent classes of individuals based on ratings of morning and evening fatigue obtained prior to, during, and for 4 months following completion of radiation therapy. Differences in single nucleotide polymorphisms and haplotypes in 15 cytokine genes were evaluated between the latent classes. Multiple logistic regression was used to assess the effect of phenotypic and genotypic characteristics on morning and evening fatigue class membership. Associations were found between morning fatigue and number of comorbidities as well as variations in tumor necrosis factor alpha (TNFA) rs1800629 and rs3093662. Evening fatigue was associated with caring for children at home and variations in interleukin 4 (IL4) rs2243248 and TNFA rs2229094. Younger age and lower performance status were associated with both morning and evening fatigue. These findings suggest that inflammatory mediators are associated with the development of morning and evening fatigue. However, because different phenotypic characteristics and genomic markers are associated with diurnal variations in fatigue, morning and evening fatigue may be distinct but related symptoms.
journal_name
Biol Res Nursjournal_title
Biological research for nursingauthors
Dhruva A,Aouizerat BE,Cooper B,Paul SM,Dodd M,West C,Wara W,Lee K,Dunn LB,Langford DJ,Merriman JD,Baggott C,Cataldo J,Ritchie C,Kober KM,Leutwyler H,Miaskowski Cdoi
10.1177/1099800414534313subject
Has Abstractpub_date
2015-03-01 00:00:00pages
175-84issue
2eissn
1099-8004issn
1552-4175pii
1099800414534313journal_volume
17pub_type
杂志文章abstract:BACKGROUND:To report the complexity and richness of study variables within biological nursing research, authors often use tables; however, the ease with which consumers understand, synthesize, evaluate, and build upon findings depends partly upon table design. OBJECTIVES:To assess and compare table characteristics wit...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800417724901
更新日期:2018-01-01 00:00:00
abstract::Depression is the leading cause of disability worldwide, and its prevalence is 2 times higher in women than in men. There is, however, a lack of data on sex-specific pathophysiology of this disorder. The purpose of this systematic review is to identify the biological sex differences found in major depressive disorder ...
journal_title:Biological research for nursing
pub_type: 杂志文章
doi:10.1177/1099800418776082
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abstract::Stress during pregnancy has been associated with a number of adverse outcomes. This study compared and correlated neuroendocrine parameters in women (n=8) who self-reported battering during their pregnancy to those in women who did not (n=8). Women who identified themselves as having a violent relationship with an int...
journal_title:Biological research for nursing
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abstract::Cytokines are small signaling proteins released from a variety of cells that influence virtually every aspect of growth and development and every host response to infection, injury, and inflammation. Because of their widespread and potent effects across the life span, cytokines without a doubt influence nursing resear...
journal_title:Biological research for nursing
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doi:10.1177/109980040000200105
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abstract::The ability to maintain balance is often taken for granted, yet it is the foundation for mobility and overall functional independence throughout the life span. The purpose of this article is to define balance, review the components of balance, and describe common instruments used to measure balance. Clinical screening...
journal_title:Biological research for nursing
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abstract::Abdominal pain is an important symptom in irritable bowel syndrome (IBS), but patients report typical pain intensities ranging from mild to very severe. In a sample of women, the authors sought to determine whether measures of systemic autonomic activity are related to self-reported pain intensity and the occurrence o...
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abstract::Maternal posturing, in which a pregnant or laboring woman assumes specific postures with the intention of altering the position and/or presentation of the fetus within the uterus, is a safe alternative to operative procedures recommended in cases of fetal malpositions and malpresentations. Clinicians and researchers a...
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abstract:BACKGROUND:Larger veins are associated with a higher rate of success of peripheral intravenous cannulation. Although patient position affects venodilation during central venous cannulation, the association between patient position and vein size for peripheral intravenous cannulation remains unclear. PURPOSE:We examine...
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更新日期:2011-04-01 00:00:00
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journal_title:Biological research for nursing
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journal_title:Biological research for nursing
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journal_title:Biological research for nursing
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更新日期:2017-03-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2013-10-01 00:00:00
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更新日期:2014-01-01 00:00:00
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journal_title:Biological research for nursing
pub_type: 杂志文章
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更新日期:2013-01-01 00:00:00
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journal_title:Biological research for nursing
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journal_title:Biological research for nursing
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更新日期:2016-03-01 00:00:00
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journal_title:Biological research for nursing
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2003-07-01 00:00:00
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journal_title:Biological research for nursing
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更新日期:2017-01-01 00:00:00
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journal_title:Biological research for nursing
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doi:10.1177/1099800413501717
更新日期:2014-01-01 00:00:00
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journal_title:Biological research for nursing
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更新日期:2004-04-01 00:00:00
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journal_title:Biological research for nursing
pub_type: 杂志文章
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更新日期:2016-05-01 00:00:00