Abstract：
:The theoretical constructs of allostasis and allostatic load (AL) have contributed to our understanding of how constantly changing social and environmental factors impact physiological functioning and shape health and aging disparities, particularly along socioeconomic, gendered, racial, and ethnic lines. AL represents the cumulative dysregulation of biological systems with prolonged or poorly regulated allostatic responses. Nearly two decades of empirical research has focused on operationalizing the AL construct for examining the antecedents and health outcomes accompanying multisystem biological dysregulation. The purpose of this systematic review is to examine the empirical literature that quantifies the AL construct; the review also evaluates the social, environmental, and genetic antecedents of AL as well as its predictive utility for a variety of health outcomes. A total of 58 articles published between 1997 and 2012 were retrieved, analyzed, and synthesized. The results revealed considerable heterogeneity in the operationalization of AL and the measurement of AL biomarkers, making interpretations and comparisons across studies challenging. There is, however, empirical substantiation for the relationships between AL and socioeconomic status, social relationships, workplace, lifestyle, race/ethnicity, gender, stress exposure, and genetic factors. The literature also demonstrated associations between AL and physical and mental health and all-cause mortality. Targeting the antecedents of AL during key developmental periods is essential for improving public health. Priorities for future research include conducting prospective longitudinal studies, examining a broad range of antecedent allostatic challenges, and collecting reliable measures of multisystem dysregulation explicitly designed to assess AL, at multiple time points, in population-representative samples.
journal_name
Biol Res Nursjournal_title
Biological research for nursingauthors
Beckie TMdoi
10.1177/1099800412455688subject
Has Abstractpub_date
2012-10-01 00:00:00pages
311-46issue
4eissn
1099-8004issn
1552-4175pii
14/4/311journal_volume
14pub_type
杂志文章,评审abstract：:Nausea and vomiting are the most common side effects of antineoplastic chemotherapy. However, only a small number of studies have been conducted in Taiwan to determine the efficacy of acupressure in treating these side effects in cancer patients receiving chemotherapy. In this quasi-experimental study, we aimed to exp...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800416683801
更新日期：2017-03-01 00:00:00
abstract：OBJECTIVE:To investigate associations between components of cumulative risk (CR) and physiological stress responses in African American adolescents and evaluate emotion regulation as a mediator and sex as a moderator of these associations. METHODS:Cortisol and salivary alpha amylase (sAA) were collected in adolescents...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800417702742
更新日期：2017-07-01 00:00:00
abstract：:The integration of molecular genetics approaches into the study of complex health phenomena is an increasingly important and available strategy for researchers across the health science disciplines. Pain sensation and response to painful stimuli are examples of complex health phenomena that are particularly amenable t...
journal_title：Biological research for nursing
pub_type： 杂志文章,评审
doi：10.1177/1099800406289909
更新日期：2006-07-01 00:00:00
abstract：:During the menopausal transition and early postmenopause, participants in the Seattle Midlife Women's Health Study (SMWHS) experienced one of the three symptom severity clusters identified through latent class analysis: severe hot flashes with moderate sleep, mood, cognitive, and pain symptoms (high-severity hot flash...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800417753536
更新日期：2018-03-01 00:00:00
abstract：BACKGROUND:The most consistently replicated genetic variants associated with coronary heart disease (CHD) in populations of European descent have been found on chromosome 9p21. Yet there is little known about these associations in ethnic groups of African ancestry. These disease-associated variants are located in a gen...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800411403469
更新日期：2011-07-01 00:00:00
abstract：BACKGROUND:Depression and inflammation are concomitantly elevated in patients with lung cancer and may have collective survival implications. However, the longitudinal relationship between depression and inflammation in patients with metastatic lung cancer is not fully appreciated. We hypothesized that longitudinal cha...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800420959721
更新日期：2020-09-22 00:00:00
abstract：:The prevalence of obesity and obesity-related illnesses is higher among Hispanics (Latinos) than other racial and ethnic groups, and rates increase exponentially with the number of years living in the United States. Mounting evidence suggests that the origins of many chronic illnesses among disadvantaged minority grou...
journal_title：Biological research for nursing
pub_type： 杂志文章,评审
doi：10.1177/1099800412457017
更新日期：2012-10-01 00:00:00
abstract：BACKGROUND:Incidence rates of both type 1 and type 2 diabetes mellitus (DM) are increasing in youth and may eventually contribute to premature heart disease in early adulthood. This investigation explored the influence of type of diabetes, gender, body mass index (BMI), metabolic control (HbA1c), exercise beliefs and p...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800405275202
更新日期：2005-07-01 00:00:00
abstract：:Delirium is a serious complication of acute illness. Little is known, however, regarding the neurobiology of delirium, largely due to challenges in studying the complex inpatient population. Neuroimaging is one noninvasive method that can be used to study structural and functional brain abnormalities associated with d...
journal_title：Biological research for nursing
pub_type： 杂志文章,评审
doi：10.1177/1099800419849489
更新日期：2019-07-01 00:00:00
abstract：:The ability to maintain balance is often taken for granted, yet it is the foundation for mobility and overall functional independence throughout the life span. The purpose of this article is to define balance, review the components of balance, and describe common instruments used to measure balance. Clinical screening...
journal_title：Biological research for nursing
pub_type： 杂志文章,评审
doi：10.1177/109980040000100408
更新日期：2000-04-01 00:00:00
abstract：:Scientists and clinicians frequently use immunological methods (IMs) to investigate complex biological phenomena. Commonly used IMs include immunocytochemistry (IC), enzyme-linked immunosorbent assays (ELISA) and flow cytometry. Each of these methodologies exploits a common principle in IMs -the binding of an antibody...
journal_title：Biological research for nursing
pub_type： 杂志文章,评审
doi：10.1177/1099800411402494
更新日期：2011-07-01 00:00:00
abstract：:Benefits of daily physical activity are well known, but there are limited data to describe physical activity in heart failure patients who receive cardiac resynchronization therapy devices. The purpose of this pilot study was to evaluate changes in physical activity (PA) levels before and 3 months after Cardiac Resync...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800413481619
更新日期：2014-01-01 00:00:00
abstract：:Postpartum depression (PPD) is a serious mood disorder that may carry life-long consequences for a woman and her family. Multiple risk factors for PPD have been identified, including psychosocial, situational, and biological stimuli, several of which are experienced by most, if not all, postpartum women. Given the com...
journal_title：Biological research for nursing
pub_type： 杂志文章,评审
doi：10.1177/1099800410362112
更新日期：2010-07-01 00:00:00
abstract：BACKGROUND:Larger veins are associated with a higher rate of success of peripheral intravenous cannulation. Although patient position affects venodilation during central venous cannulation, the association between patient position and vein size for peripheral intravenous cannulation remains unclear. PURPOSE:We examine...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800419893027
更新日期：2020-04-01 00:00:00
abstract：:Central nervous system (CNS)-directed treatment for acute lymphoblastic leukemia, used to prevent disease recurrence in the brain, is essential for survival. Systemic and intrathecal methotrexate, commonly used for CNS-directed treatment, have been associated with cognitive problems during and after treatment. The cor...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800416644780
更新日期：2016-10-01 00:00:00
abstract：:Interpretation of changes in health and health care utilization patterns across the life span depends on an understanding of the effects of age, period, and cohort. The purpose of this article is to illustrate differences among three generations of women in demographic factors, health risk factors, and health status i...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800410373804
更新日期：2010-10-01 00:00:00
abstract：OBJECTIVES:The objectives of this study were to determine the change in gene expression between two time points following stroke and to identify biomarkers of stroke recovery through gene expression profiling and pathway analysis. METHODS:Peripheral blood was collected from 34 ischemic stroke patients (confirmed by ma...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800414546492
更新日期：2015-05-01 00:00:00
abstract：OBJECTIVE:This study used a candidate gene approach to examine genomic variation associated with pain, anxiety, and distress in children undergoing a medical procedure. STUDY DESIGN:Children aged 4-10 years having an IV catheter insertion were recruited from three Midwestern children's hospitals. Self-report measures ...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800417692878
更新日期：2017-05-01 00:00:00
abstract：:The purposes of this quasi-experimental pilot study were to determine adherence to a 12-week group-based moderate-intensity walking program for sedentary adult outpatients with serious and persistent mental illness and to examine change from baseline to after the walking program in health status (mental and physical h...
journal_title：Biological research for nursing
pub_type： 临床试验,杂志文章
doi：10.1177/1099800405278116
更新日期：2005-10-01 00:00:00
abstract：:Research that uses a psychoneuroimmunology (PNI) framework seeks to determine whether valid associations exist among stress, immune function, and health. These associations are difficult to conclusively determine due to the fact that PNI research is fraught with methodological difficulties. These difficulties arise fr...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/10900402003004002
更新日期：2002-04-01 00:00:00
abstract：:The current study was performed to evaluate the antinociceptive and antiedematogenic properties of andrographolide isolated from the leaves of Andrographis paniculata using two animal models. Antinociceptive activity was evaluated using the acetic acid- induced writhing and the hot-plate tests, while antiedematogenic ...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800409343311
更新日期：2010-01-01 00:00:00
abstract：BACKGROUND:Eating disorders are a significant cause of morbidity and mortality. The etiology and maintenance of eating-disorder symptoms are not well understood. Evidence suggests that there may be gustatory alterations in patients with eating disorders. OBJECTIVE:This article systematically reviews research assessing...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800419872824
更新日期：2020-01-01 00:00:00
abstract：:Cytokines are small signaling proteins released from a variety of cells that influence virtually every aspect of growth and development and every host response to infection, injury, and inflammation. Because of their widespread and potent effects across the life span, cytokines without a doubt influence nursing resear...
journal_title：Biological research for nursing
pub_type： 杂志文章,评审
doi：10.1177/109980040000200105
更新日期：2000-07-01 00:00:00
abstract：:Cytokines such as angiogenin (ANG) and interleukin (IL-8) have been shown to be related to depressive symptoms and inflammatory diseases like coronary heart disease. They may thus be used as stress biomarkers to identify and prevent health problems. To investigate the relationship between cytokines and nurses' job-rel...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800408323219
更新日期：2008-10-01 00:00:00
abstract：PURPOSE:In recent years, researchers have noted an "obesity paradox," where individuals with obesity survive sepsis at higher rates than their nonobese counterparts. This systematic review summarizes the literature on studies examining the association between obesity and 1-year mortality among patients admitted with se...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800419876070
更新日期：2020-01-01 00:00:00
abstract：PURPOSE:The purpose of this study was to explore gene expression changes in fatigued men with nonmetastatic prostate cancer receiving localized external beam radiation therapy (EBRT). METHODS:Fatigue was measured in 40 men with prostate cancer (20 receiving EBRT and 20 controls on active surveillance) using the Functi...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800415618786
更新日期：2016-05-01 00:00:00
abstract：:Multiple chemical sensitivity (MCS) is a chronic condition prevalent in women; the symptoms are reproducible with repeated low-level chemical exposure. Evidence gathered through clinical observations suggests that women with MCS may be at risk for autonomic nervous system dysfunction as evidenced by abnormal heart rat...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800408324251
更新日期：2009-01-01 00:00:00
abstract：PURPOSE:Activity restriction (AR), one of the most common interventions used in high-risk pregnancies, may exacerbate loss of bone mass. The purpose of this study was to determine changes over time in bone resorption in hospitalized AR women during late pregnancy. METHODS:This was a short-term prospective study conduc...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800412463120
更新日期：2014-01-01 00:00:00
abstract：:The purpose of this study was to compare physiological and psychological reactions among Taiwanese women with different degrees of severity of nausea and vomiting (NV) during pregnancy. Based on their scores on the Index of Nausea, Vomiting, and Retching (INVR), 59 pregnant women ≥ 18 years of age, with single gestati...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800410388506
更新日期：2011-10-01 00:00:00
abstract：:Approximately half of the Canadian adults have sedentary lifestyles that increase their risk of developing cardiovascular disease (CVD). Women are 10 times more likely to die from CVD than from any other disease. Their risk almost doubles with the onset of menopause, which may result in increased body iron burden and ...
journal_title：Biological research for nursing
pub_type： 杂志文章
doi：10.1177/1099800413501717
更新日期：2014-01-01 00:00:00
