Diversity of the mechanisms of resistance to beta-lactam antibiotics.

Abstract:

:The sensitivity of a bacterium to beta-lactam antibiotics depends upon the interplay between 3 independent factors: the sensitivity of the essential penicillin-binding enzyme(s), the quantity and properties of the beta-lactamase(s) and the diffusion barrier that the outer-membrane of Gram-negative bacteria can represent. Those three factors can be modified by mutations or by the horizontal transfer of genes or portions of genes.

journal_name

Res Microbiol

journal_title

Research in microbiology

authors

Frère JM,Joris B,Granier B,Matagne A,Jacob F,Bourguignon-Bellefroid C

doi

10.1016/0923-2508(91)90084-n

subject

Has Abstract

pub_date

1991-07-01 00:00:00

pages

705-10

issue

6

eissn

0923-2508

issn

1769-7123

pii

0923-2508(91)90084-N

journal_volume

142

pub_type

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