Abstract:
:This study aimed to clarify the role of peritoneal T-lymphocytes in peritoneal immune defense mechanisms. This study was designed to examine the changes in T-cell subpopulations during peritonitis in patients treated with continuous ambulatory peritoneal dialysis (CAPD). Our observations were correlated to responses to treatment and with outcomes. The present study was carried out in 20 patients (8 males, 12 females) under CAPD. Peritonitis was diagnosed according to the criteria defined by the Ad Hoc Advisory Committee on Peritonitis Management. Peritoneal dialysate effluent (PDE) samples were collected from our patients, and lymphocyte subsets (CD2+, CD3+, CD3+/4+, CD3+/8+, CD3-/16+56+, CD4/CD8 ratio) were quantitated by using monoclonal antibodies. CD4/CD8 ratio was measured every day during peritonitis until the patients had completely recovered. The serial measurements of the CD4/CD8 ratio made in the PDE during peritonitis followed two patterns: the first pattern was characterized by a progressive increase in the CD4/CD8 ratio. The CD4/CD8 ratios on days 5, 6, and 7 were significantly higher than those on day 1 (P < 0.05). Overall, the patients who exhibited pattern 1 had favorable clinical courses. The second pattern was characterized by high initial CD4/CD8 ratios, which progressively decreased significantly (P < 0.05). This second pattern was associated with a delayed clinical response to treatment. Symptoms and signs of peritonitis persisted beyond 72 h. The pattern of the CD4/CD8 ratio in PDE may determine the outcome of peritonitis in CAPD patients.
journal_name
Artif Organsjournal_title
Artificial organsauthors
Griveas I,Fleva A,Karanikas E,Gogos K,Sakellariou Gdoi
10.1111/j.1525-1594.2009.00802.xsubject
Has Abstractpub_date
2009-12-01 00:00:00pages
1091-5issue
12eissn
0160-564Xissn
1525-1594pii
AOR802journal_volume
33pub_type
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journal_title:Artificial organs
pub_type: 杂志文章
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更新日期:2013-05-01 00:00:00
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journal_title:Artificial organs
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journal_title:Artificial organs
pub_type: 杂志文章
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更新日期:2001-09-01 00:00:00
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journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/j.1525-1594.1984.tb04321.x
更新日期:1984-11-01 00:00:00
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journal_title:Artificial organs
pub_type: 杂志文章
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journal_title:Artificial organs
pub_type: 杂志文章
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journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1046/j.1525-1594.2001.06904.x
更新日期:2001-11-01 00:00:00
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journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/aor.13647
更新日期:2020-07-01 00:00:00
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journal_title:Artificial organs
pub_type: 杂志文章
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journal_title:Artificial organs
pub_type: 杂志文章
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更新日期:1984-02-01 00:00:00
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journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/j.1525-1594.1995.tb02409.x
更新日期:1995-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1046/j.1525-1594.2000.06482-2.x
更新日期:2000-02-01 00:00:00
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journal_title:Artificial organs
pub_type: 杂志文章
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更新日期:1978-08-01 00:00:00
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journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1046/j.1525-1594.1999.06444.x
更新日期:1999-09-01 00:00:00
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journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/aor.12169
更新日期:2014-04-01 00:00:00
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journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/j.1525-1594.2008.00654.x
更新日期:2008-12-01 00:00:00
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journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1046/j.1525-1594.1999.06291.x
更新日期:1999-01-01 00:00:00
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journal_title:Artificial organs
pub_type: 杂志文章
doi:
更新日期:2001-04-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2018-08-01 00:00:00
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journal_title:Artificial organs
pub_type: 杂志文章
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journal_title:Artificial organs
pub_type: 杂志文章
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更新日期:1989-04-01 00:00:00
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journal_title:Artificial organs
pub_type: 杂志文章
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更新日期:2001-05-01 00:00:00
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journal_title:Artificial organs
pub_type: 临床试验,杂志文章
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更新日期:1995-08-01 00:00:00
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journal_title:Artificial organs
pub_type: 杂志文章
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更新日期:1994-03-01 00:00:00
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journal_title:Artificial organs
pub_type: 杂志文章
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更新日期:2010-06-01 00:00:00
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journal_title:Artificial organs
pub_type: 杂志文章
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更新日期:1983-02-01 00:00:00
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journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/j.1525-1594.1994.tb02227.x
更新日期:1994-06-01 00:00:00
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journal_title:Artificial organs
pub_type: 杂志文章
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更新日期:1992-04-01 00:00:00