Demonstration of an antigenic protein specific for Salmonella typhi.

abstract：:Dexamethasone (Dex) causes osteoblast cell injuries. In the present research, we tested the potential effect of SC79, a novel and specific Akt activator, against Dex in osteoblasts. In primary murine osteoblasts and osteoblastic MC3T3-E1 cells, pretreatment with SC79 significantly attenuated Dex-induced cell death. Fu...

journal_title：Biochemical and biophysical research communications

authors： Li ST,Chen NN,Qiao YB,Zhu WL,Ruan JW,Zhou XZ

更新日期：2016-10-07 00:00:00

abstract：:In this report we present evidence that a guanine nucleotide regulatory protein, Gi, mediates opiate action in the rat brain striatum. Opiates inhibit basal adenylate cyclase activity in rat brain striatum. This effect on adenylate cyclase is dose-dependently attenuated by pretreatment of membranes with pertussis toxi...

journal_title：Biochemical and biophysical research communications

authors： Abood ME,Law PY,Loh HH

更新日期：1985-03-15 00:00:00

abstract：:By constructing a new type of thermal detector, rapid production of heat was demonstrated during the rising phase of the action potential of the eel electric organs evoked by direct electric stimulation. Following the indirect (synapse-mediated) action potential of the organs, the existence of very large and variable ...

journal_title：Biochemical and biophysical research communications

authors： Tasaki I,Byrne PM

更新日期：1993-12-15 00:00:00

abstract：:Human Bruton's tyrosine kinase (hBtk) plays a key role in growth and metabolism of B cells, but its dysfunctions cause various B-cell malignancies. Inhibitors targeting the ATP-binding pocket of hBtk have been developed, but they have several drawbacks such as adverse side effects and occurrence of drug-resistant muta...

journal_title：Biochemical and biophysical research communications

authors： Jeong S,Sohn YK,Choi Y,Park J,Kim HS

更新日期：2020-05-21 00:00:00

abstract：:We examined the effect of low density lipoprotein (LDL) on histamine release from purified human lung mast cells. LDL inhibited anti-IgE- induced histamine release in a dose-dependent manner, with 100 micrograms/ml LDL-protein inhibiting histamine release by 53 +/- 8% (mean +/- SEM); half-maximal inhibition occurred a...

journal_title：Biochemical and biophysical research communications

authors： Schulman ES,Quinn TJ,Post TJ,O'Donnell P,Rodriguez A,Gonen B

更新日期：1987-10-29 00:00:00

abstract：:Circular (circ)RNAs have been implicated in cancer development. However, few studies have examined the role of circRNAs in papillary thyroid cancer (PTC). In this study we found that circNUP214 was upregulated in clinical PTC specimens relative to adjacent normal tissue. In vitro analyses showed that circNUP214 knockd...

journal_title：Biochemical and biophysical research communications

authors： Li X,Tian Y,Hu Y,Yang Z,Zhang L,Luo J

更新日期：2018-12-09 00:00:00

abstract：:The E. coli ogt O6-alkylguanine-DNA alkyltransferase has two cysteine residues positioned identically with respect to cysteines in the E. coli ada O6-alkylguanine-DNA alkyltransferase. In order to assess their function, these residues were each substituted by a glycine to generate altered forms of the ogt protein. Mut...

journal_title：Biochemical and biophysical research communications

authors： Harris LC,Potter PM,Margison GP

更新日期：1992-08-31 00:00:00

abstract：:Endothelin-1 is a potent vasoactive peptide which may play a role in the regulation of vascular resistance through its autocrine/paracrine effects. We have investigated the influence of salt loading on the renal and cardiac production of endothelin-1 in stroke prone spontaneously hypertensive rats, a classical model o...

journal_title：Biochemical and biophysical research communications

authors： Feron O,Salomone S,Godfraind T

更新日期：1995-04-06 00:00:00

abstract：:Borate/boric acid solutions have distinctive effects on the absorption and fluorescence emission spectra of dityrosine. In the presence of excess borate/boric acid, the fluorescence emission maximum of the singly ionized dityrosine chromophore shifts from 407 nm (quantum yield = 0.80) to 374 nm (quantum yield = 0.14)....

journal_title：Biochemical and biophysical research communications

authors： Malencik DA,Anderson SR

更新日期：1991-07-15 00:00:00

abstract：:Myotonic dystrophy (DM) is an autosomal dominant human disorder, caused by the abnormal expansion of a CTG trinucleotide repeat in the 3' untranslated region of a protein kinase gene (DMPK). Muscle symptoms are a common feature of the disorder and in the adult onset cases there are increased patterns of muscle fibre d...

journal_title：Biochemical and biophysical research communications

authors： Okoli G,Carey N,Johnson KJ,Watt DJ

更新日期：1998-05-29 00:00:00

abstract：:At high dietary levels in vivo, both 13-cis-retinoic acid and calcium glucarate inhibit the induction of rat mammary tumors by 7,12-dimethylbenz(a)anthracene. The present study shows that sub-optimal dietary levels of each, which individually have no effect on tumor induction, when combined together in the diet, signi...

journal_title：Biochemical and biophysical research communications

authors： Abou-Issa H,Koolemans-Beynen A,Minton JP,Webb TE

更新日期：1989-09-29 00:00:00

abstract：:The serine proteinase catalyzed hydrolysis of N-ethoxycarbonyl-D-phenylalanyl-L-prolyl-alpha-azalysine p- nitrophenyl ester (Eoc-D-Phe-Pro-azaLys-ONp) was investigated at pH 6.2 and 21.0 degrees C. The results are consistent with the minimum three-step catalytic mechanism. The acylation step is rate limiting for human...

journal_title：Biochemical and biophysical research communications

authors： Balliano G,Milla P,Giordano C,Gallina C,Coletta M,Menegatti E,Rizzi M,Bolognesi M,Ascenzi P

更新日期：1996-08-14 00:00:00

abstract：:A ferric low-spin species with an anomalously small g3-g1 separation generated by the reaction of Fe(III)tetraphenylporphyrin with t-butylhydroperoxide in the presence of tatramethylammonium hydroxide was characterized by ESR spectroscopy. The reaction kinetics, investigated by monitoring ESR intensity, indicated that...

journal_title：Biochemical and biophysical research communications

authors： Tajima K,Ishizu K,Sakurai H,Ohya-Nishiguchi H

更新日期：1986-03-28 00:00:00

abstract：:Human monocarboxylate transporters (hMCTs) mediate the transport of monocarboxylates across plasma membranes. One such transporter, hMCT9, has been shown to be related to serum uric acid levels and the risk of renal overload gout. However, the functional characteristics of hMCT9 remain unknown. The aim of this study w...

journal_title：Biochemical and biophysical research communications

authors： Futagi Y,Narumi K,Furugen A,Kobayashi M,Iseki K

更新日期：2020-02-05 00:00:00

abstract：:Although the neuron-restrictive silencer element (NRSE/Regard) has been shown to function as a negative-acting DNA regulatory element to prevent the expression of neuron-specific genes in non-neuronal cells, little is known about its silencing effect on transcription in primary glial cells nor its effect on transcript...

journal_title：Biochemical and biophysical research communications

authors： Tabuchi A,Nakatani C,Nakaoka R,Naruse Y,Kojima T,Mori N,Tsuda M

更新日期：1999-08-02 00:00:00

abstract：:Metformin, a widely used anti-diabetic drug, is emerging as a potential anticancer agent but the mechanisms involved remain incompletely understood. Here, we demonstrate that the potency of metformin induced AMPK activation, as shown by the phosphorylation of its substrates acetyl-CoA carboxylase (ACC) at Ser(79) and ...

journal_title：Biochemical and biophysical research communications

authors： Sinnett-Smith J,Kisfalvi K,Kui R,Rozengurt E

更新日期：2013-01-04 00:00:00

abstract：:Hyperglycemia-induced podocyte injury plays a vital role in the development of diabetic nephropathy. Sulfiredoxin-1 (Srxn1) is emerging as a cytoprotective protein that protects from various insults in a wide range of cell types. However, whether Srxn1 is involved in regulating hyperglycemia-induced podocyte injury an...

journal_title：Biochemical and biophysical research communications

authors： Shen Y,Chen S,Zhao Y

更新日期：2019-09-03 00:00:00

abstract：:Semicarbazide-sensitive amine oxidase (SSAO) activity in plasma is increased in diabetes, and in particular, in diabetic patients with vascular complications. It has been speculated that SSAO is involved in the development of such complications due to the production of cytotoxic compounds. In this work, we have induce...

journal_title：Biochemical and biophysical research communications

authors： Gokturk C,Nordquist J,Sugimoto H,Forsberg-Nilsson K,Nilsson J,Oreland L

更新日期：2004-12-17 00:00:00

abstract：:MicroRNAs (miRNAs) are small noncoding RNAs that regulate target gene expression through translation repression or messenger RNA degradation. MiR-15a and 16-1 form a cluster at the chromosomal region 13q14, which is frequently deleted or down-regulated in chronic lymphocytic leukemia. Arsenic trioxide (As(2)O(3), ATO)...

journal_title：Biochemical and biophysical research communications

authors： Gao SM,Chen C,Wu J,Tan Y,Yu K,Xing CY,Ye A,Yin L,Jiang L

更新日期：2010-12-10 00:00:00

abstract：:Long noncoding RNA (lncRNAs) UCA1 has been known to be critical for the chondrogenic differentiation of marrow mesenchymal stem cells (MSCs). In this study, we explore the effects and mechanisms of UCA1 on the promotion of chondrogenesis of MSCs. During the processes of chondrogenic differentiation of MSCs, UCA1, miRN...

journal_title：Biochemical and biophysical research communications

authors： Shu T,He L,Wang X,Pang M,Yang B,Feng F,Wu Z,Liu C,Zhang S,Liu B,Wang Q,Rong L

更新日期：2019-06-18 00:00:00

abstract：:Recently, Stock et al. (J. Biol. Chem. 261, 15915-15922 [1986]) described a model enzyme system composed of horseradish peroxidase, hydrogen peroxide, phenol, glutathione and styrene. This system forms glutathione-styrene conjugates. Glutathione radicals and carbon-centered radicals are intermediates in this process. ...

journal_title：Biochemical and biophysical research communications

authors： Kanofsky JR

更新日期：1989-03-31 00:00:00

abstract：:The classified sediment with ethanol from sera of nude mice and humans showed a disturbing effect on L1210 cells in vitro and a lifesaving effect on L1210 cell-bearing mice in vivo. This factor was purified more than 2300-fold to a specific activity of approximately 1 X 10(5) U/mg by ethanol classified precipitation, ...

journal_title：Biochemical and biophysical research communications

authors： Sakagami Y,Manabe H

更新日期：1984-04-30 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) has been identified as a leading cause of tumor-associated death around the world. Presently, it is necessary to find effective and safe therapy for its treatment in clinic. Jervine (Jer), a sterodial alkaloid from rhizomes of Veratrum album, exhibits anti-inflammatory and anti-cance...

journal_title：Biochemical and biophysical research communications

authors： Lei W,Huo Z

更新日期：2020-12-10 00:00:00

abstract：:The characterization of the genomic organization of the B2 bradykinin receptor gene enabled us to systematically search for polymorphic markers in this gene in a South German cohort (N = 179). We identified at least three polymorphic sites in each of the three exons existing: (i) in exon 1 next to the promoter region,...

journal_title：Biochemical and biophysical research communications

authors： Braun A,Kammerer S,Böhme E,Müller B,Roscher AA

更新日期：1995-06-06 00:00:00

abstract：:Cholestasis and hepatitis can cause continuous liver damage that may ultimately result in liver fibrosis. In a previous study, we demonstrated that microRNA-29a (miR-29a) protects against liver fibrosis. Toll-like receptor 2 (TLR2) and TLR4 are pattern recognition receptors of bacterial lipoprotein and lipopolysacchar...

journal_title：Biochemical and biophysical research communications

authors： Lin YC,Wang FS,Yang YL,Chuang YT,Huang YH

更新日期：2018-02-12 00:00:00

abstract：:Huntington's disease (HD) has been recently shown to have a horizontally transmitted, prion-like pathology. Thus, the migration of polyglutamine-containing aggregates to acceptor cells is important for the progression of HD. These aggregates contain glyceraldehyde-3-phosphate dehydrogenase (GAPDH), which increases the...

journal_title：Biochemical and biophysical research communications

authors： Lazarev VF,Mikhaylova ER,Dutysheva EA,Suezov RV,Guzhova IV,Margulis BA

更新日期：2017-06-03 00:00:00

abstract：:Cullin-RING ligases (CRLs) regulate diverse cellular functions such as cell cycle progression and cytokine signaling by ubiquitinating key regulatory proteins. The activity of CRLs is controlled by Nedd8 modification of the cullin subunits. Recent reports have suggested that CAND1, which specifically binds to unmodifi...

journal_title：Biochemical and biophysical research communications

authors： Min KW,Kwon MJ,Park HS,Park Y,Yoon SK,Yoon JB

更新日期：2005-09-02 00:00:00

abstract：:Cyclosporin accumulation was reduced by 50% or more in multidrug- resistant CHRC5 CHO cells with high levels of P-glycoprotein expression compared to drug sensitive AuxB1 CHO cells. This difference could be overcome by verapamil which is known to interact with P-glycoprotein and reverse multidrug resistance. The diffe...

journal_title：Biochemical and biophysical research communications

authors： Goldberg H,Ling V,Wong PY,Skorecki K

更新日期：1988-04-29 00:00:00

abstract：:Hepatocytes cultured on type I collagen proliferate in response to mitogenic growth factors yet de-differentiate. By contrast, hepatocytes on laminin-rich gels (EHS) demonstrate stable differentiated functions, while DNA synthesis is negligible. Here we have confirmed that this lack of proliferation was not due to det...

journal_title：Biochemical and biophysical research communications

authors： Gardner MJ,Fletcher K,Pogson CI,Strain AJ

更新日期：1996-11-12 00:00:00

abstract：:L1 elements are mammalian retrotransposons contributing to genome evolution and causing rare mutations in human. We describe a de novo insertion of an L1 element into the dystrophin gene resulting in skipping of exon 44 and causing Duchenne muscular dystrophy in a boy. The L1 element was rearranged due to the twin-pri...

journal_title：Biochemical and biophysical research communications

authors： Musova Z,Hedvicakova P,Mohrmann M,Tesarova M,Krepelova A,Zeman J,Sedlacek Z

更新日期：2006-08-18 00:00:00