Abstract：
OBJECTIVE:To evaluate the intraocular pressure (IOP) reduction achieved by the most frequently prescribed antiglaucoma drugs in patients with normal tension glaucoma (NTG). DESIGN:Systematic review and meta-analysis. PARTICIPANTS:Fifteen randomized clinical trials reported 25 arms for peak IOP reduction, 16 arms for trough IOP reduction, and 13 arms for diurnal curve IOP reduction. METHODS:Pertinent publications were identified through systematic searches of PubMed, EMBASE, and the Cochrane Controlled Trials Register. The patients had to be diagnosed as having NTG. Methodological quality was assessed by the Delphi list on a scale from 0 to 18. The pooled 1-month IOP-lowering effects were calculated using the 2-step DerSimonian and Laird estimate method of the random effects model. MAIN OUTCOME MEASURES:Absolute and relative reductions in IOP from baseline for peak and trough moments. RESULTS:Quality scores of included studies were generally high, with a mean quality score of 12.7 (range, 9-16). Relative IOP reductions were peak, 15% (12%-18%), and trough, 18% (8%-27%) for timolol; peak, 14% (8%-19%), and trough, 12% (-7% to 31%) for dorzolamide; peak, 24% (17%-31%), and trough, 11% (7%-14%) for brimonidine; peak, 20% (17%-24%), and trough, 20% (18%-23%) for latanoprost; peak, 21% (16%-25%), and trough, 18% (14%-22%) for bimatoprost. The differences in absolute IOP reductions between prostaglandin analogues and timolol varied from 0.9 to 1.0 mmHg at peak and -0.1 to 0.2 mmHg at trough. CONCLUSIONS:Latanoprost, bimatoprost, and timolol are the most effective IOP-lowering agents in patients with NTG.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Cheng JW,Cai JP,Wei RLdoi
10.1016/j.ophtha.2009.01.036subject
Has Abstractpub_date
2009-07-01 00:00:00pages
1243-9issue
7eissn
0161-6420issn
1549-4713pii
S0161-6420(09)00096-7journal_volume
116pub_type
杂志文章,meta分析相关文献
OPHTHALMOLOGY文献大全abstract：PURPOSE:To report the therapeutic effects of ethanol (ETOH) irrigation into epithelial iris cysts (EIC). STUDY DESIGN:Retrospective noncomparative interventional case series. PARTICIPANTS:102 eyes of 102 patients aged between 4 and 71 years with EIC, with 4 months to 15 years follow-up. INTERVENTION:Under local or g...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(03)00543-8
更新日期：2003-08-01 00:00:00
abstract：:Topical carbonic anhydrase inhibitors MK-507 and sezolamide hydrochloride (previously known as MK-417) were compared in a double-masked, randomized, placebo-controlled study in 82 patients with bilateral primary open-angle glaucoma or ocular hypertension. MK-507 was given every 8 or 12 hours, sezolamide every 8 hours,...
journal_title：Ophthalmology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/s0161-6420(91)32295-4
更新日期：1991-03-01 00:00:00
abstract：:Cystic intranasal masses were found in seven newborn infants with congenital dacryocystocele. The cysts were a direct extension of the nasolacrimal duct, located beneath the inferior turbinate. Nasal obstruction was present in three infants and was severe enough to cause respiratory distress in two neonates with bilat...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(91)32149-3
更新日期：1991-08-01 00:00:00
abstract：PURPOSE:Droperidol and the new serotonin-3 antagonists are effective drugs for the prophylaxis of postoperative nausea and vomiting (PONV). The aim of this trial was to evaluate whether dolasetron could be a substitute for droperidol, because the Food and Drug Administration has required a Black Box warning on the drop...
journal_title：Ophthalmology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.ophtha.2004.01.031
更新日期：2004-08-01 00:00:00
abstract：PURPOSE:To determine in vivo confocal microscopy diagnostic criteria to diagnose Acanthamoeba keratitis (AK) using polymerase chain reaction (PCR) as the reference diagnostic technique. DESIGN:Retrospective case-control study. Data were recorded prospectively and analyzed retrospectively. PARTICIPANTS:Fifty patients ...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2017.08.037
更新日期：2018-02-01 00:00:00
abstract：OBJECTIVE:Hyperopic anisometropia is a risk factor for amblyopia. Disc areas and axial lengths are reduced in amblyopic eyes. This study's aim was to investigate the differences in the relative size of the optic disc in 5 groups of eyes: (1) normal right eyes; (2) smaller eyes of nonamblyopic, anisometropic, bilateral ...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2003.05.020
更新日期：2004-02-01 00:00:00
abstract：PURPOSE:To investigate the anatomic relation between the optic nerve and the adjacent intracranial internal carotid artery (ICA) in patients with unexplained optic neuropathy. METHODS:Coronal magnetic resonance images (MRIs) of 20 patients with unexplained optic neuropathy and 20 age-matched controls were evaluated wi...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(96)30664-7
更新日期：1996-03-01 00:00:00
abstract：:Immunohistochemical staining analysis using monoclonal antibodies was performed on 107 recipient corneas removed at graft. There were significantly more infiltrating cells bearing one or more of the leukocyte-common antigen, class II major histocompatibility complex antigens, various myeloid-lineage markers, and a per...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(89)32949-6
更新日期：1989-01-01 00:00:00
abstract：OBJECTIVE:To describe three cases of squamous cell carcinoma of the conjunctiva presenting with corneal and scleral inflammation, thinning, and perforation without any tumor formation. DESIGN:Three case reports. PARTICIPANTS:Three male subjects aged 76, 66, and 61 years. INTERVENTION:The subjects had symptoms of ext...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(00)00585-6
更新日期：2001-03-01 00:00:00
abstract：OBJECTIVE:To evaluate the ocular effects of blunt trauma due to injury from a paintball pellet. DESIGN:Noncomparative case series. PARTICIPANTS:Thirteen patients who suffered ocular injury from paintballs are described. The patients presented to six different civilian and military emergency departments in tertiary ca...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/S0161-6420(99)90112-4
更新日期：1999-03-01 00:00:00
abstract：PURPOSE:To assess the prevalence of subretinal drusenoid deposits (SDD) in older adults with healthy maculas and early and intermediate age-related macular degeneration (AMD) using multimodal imaging. DESIGN:Cross-sectional study. PARTICIPANTS:A total of 651 subjects aged ≥60 years enrolled in the Alabama Study of Ea...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2015.12.034
更新日期：2016-05-01 00:00:00
abstract：:Five patients seen in a one-year period with advanced malignant melanoma of the choroid in eyes with low visual acuity and clear media are reported. The low visual acuity appeared clinically to be antecedent to the malignant tumor; although in certain cases it may have been related to the occult melanoma, this was not...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(79)35423-9
更新日期：1979-06-01 00:00:00
abstract：PURPOSE:To study the dexamethasone concentration in aqueous humor, vitreous, and serum of patients after repeated topical application of dexamethasone disodium phosphate. DESIGN:Prospective nonrandomized comparative trial. PARTICIPANTS:Twenty phakic patients scheduled for a first vitrectomy. METHODS:All participants...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(02)01176-4
更新日期：2002-10-01 00:00:00
abstract：:Perfluoropropane (C3F8) was injected into nine eyes of six cynomolgus monkeys. In all nine eyes, macular changes consistent with the development of a macular cyst were noted within 3 months after injection. On fluorescein angiography, there was no evidence of retinal vascular leakage associated with the macular cysts....
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(91)32259-0
更新日期：1991-04-01 00:00:00
abstract：PURPOSE:To investigate optic disc margin anatomic features in myopic eyes with open-angle glaucoma (OAG) using spectral-domain (SD) OCT. DESIGN:Cross-sectional study. PARTICIPANTS:Two hundred four eyes of 102 participants with OAG and 106 eyes of 53 participants without glaucoma with axial length of 24 mm or more. M...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2018.07.004
更新日期：2018-12-01 00:00:00
abstract：UNLABELLED:TOPIC/PURPOSE: To assess the clinical usefulness and relevance of indocyanine green angiography (ICG) in the investigation of chorioretinal disorders and assess specifically in what conditions it may add useful information to that obtained using standard fluorescein angiography. CLINICAL RELEVANCE:Many publ...
journal_title：Ophthalmology
pub_type： 杂志文章,评审
doi：10.1016/s0161-6420(02)01563-4
更新日期：2003-01-01 00:00:00
abstract：OBJECTIVE:To develop and validate a predictive model to estimate the probability of being nonadherent to topical glaucoma medications. DESIGN:Prospective cohort study. PARTICIPANTS:Patients being treated with once-daily prostaglandin eye drops. METHODS:A predictive model for nonadherence was developed from the Trava...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2013.01.002
更新日期：2013-07-01 00:00:00
abstract：OBJECTIVE:To compare the long-term efficacy of intraoperative 5-fluorouracil (5-FU) and mitomycin C (MMC) in primary trabeculectomy. DESIGN:Comparative case series and extension of a prospective, randomized controlled trial. PARTICIPANTS:One hundred fifteen eyes of 103 subjects undergoing primary trabeculectomy with ...
journal_title：Ophthalmology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ophtha.2008.08.009
更新日期：2009-02-01 00:00:00
abstract：OBJECTIVE:To describe the safety and efficacy of an analgesia protocol that enables the surgeon to maintain control over an alert patient experiencing seemingly painless ambulatory cataract surgery, while eliminating the risks and side effects associated with general, local, topical, and intracameral anesthesia. DESIG...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(00)00008-7
更新日期：2000-05-01 00:00:00
abstract：PURPOSE:The spaceflight-associated neuro-ocular syndrome (SANS) affects astronauts on missions to the International Space Station (ISS). The SANS has blurred vision and ocular changes as typical features. The objective of this study was to investigate if microgravity can create deformations or movements of the eye or o...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2020.07.007
更新日期：2021-02-01 00:00:00
abstract：:Merkel cell carcinoma is an infrequent but highly aggressive cutaneous neoplasm. Previous reports of ocular involvement have included primary eyelid carcinomas, eyelid and orbital metastases, and a clinically diagnosed choroidal metastasis. The authors report the histopathologic documentation of a metastatic lesion to...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(91)32116-x
更新日期：1991-09-01 00:00:00
abstract：OBJECTIVE:To study the prevalence of ocular manifestations in African American and Caucasian patients with biopsy-proven sarcoidosis at the initial ophthalmic examination and to determine the relationship between angiotensin-converting enzyme (ACE) levels, chest x-ray findings, and ocular signs of sarcoidosis. DESIGN:...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2006.05.074
更新日期：2007-02-01 00:00:00
abstract：PURPOSE:To evaluate the visual outcome, number of injections, and direct medical cost of a "treat and extend" regimen (TER) in managing neovascular age-related macular degeneration (nAMD) with intravitreal ranibizumab. DESIGN:Retrospective, interventional, consecutive case series. PARTICIPANTS:Ninety-two eyes of 92 p...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2010.02.032
更新日期：2010-11-01 00:00:00
abstract：PURPOSE:Advances in cataract removal using topical anesthesia through a clear corneal microincision have created a new opportunity to fully correct refractive errors at the time of cataract surgery. This study was undertaken to assess the effectiveness of keratolenticuloplasty (KLP), the simultaneous modification of th...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(97)30304-2
更新日期：1997-03-01 00:00:00
abstract：:Normal crystalline lenses and a variety of primary and secondary cataracts were photographed with a contact clinical specular microscope having a new W10X long working distance objective. In the normal lens, the anterior and posterior cell pattern and the lens fiber pattern could be seen. In patients with developing c...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(83)34548-6
更新日期：1983-04-01 00:00:00
abstract：:Trabeculotomy ab externo and goniotomy seem to be in many ways equivalent, and both are particularly successful in previously unoperated cases of primary infantile glaucoma that become apparent postnatally but before the age of 1 year. It may be more difficult to achieve a technically perfect procedure with trabeculot...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(83)34484-5
更新日期：1983-07-01 00:00:00
abstract：PURPOSE:To describe patient characteristics, classification, and onset of prethreshold retinopathy of prematurity (ROP), and ocular findings at 6 months corrected age in infants with birth weights <500 g who were enrolled in the Early Treatment for Retinopathy of Prematurity (ETROP) Study. DESIGN:Multicenter randomize...
journal_title：Ophthalmology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.ophtha.2010.09.031
更新日期：2011-06-01 00:00:00
abstract：OBJECTIVE:To test an educational intervention promoting the purchase of spectacles among Chinese children. DESIGN:Randomized, controlled trial. PARTICIPANTS:Children in years 1 and 2 of all 20 junior and senior high schools (ages 12-17 years) in 3 rural townships in Guangdong, China. METHODS:Children underwent visua...
journal_title：Ophthalmology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.ophtha.2011.06.016
更新日期：2011-12-01 00:00:00
abstract：OBJECTIVE:To assess the posterior corneal power and asphericity changes after myopic laser in situ keratomileusis (LASIK) and to correlate these changes with the amount of correction and the residual stromal bed thickness. DESIGN:Prospective nonrandomized (self-controlled) comparative study. PARTICIPANTS:Fifty-seven ...
journal_title：Ophthalmology
pub_type： 临床试验,杂志文章
doi：10.1016/s0161-6420(00)00581-9
更新日期：2001-04-01 00:00:00
abstract：:Ketorolac tromethamine solution 0.5% (1 drop 3 times daily) was more effective than the placebo vehicle solution in suppressing postoperative anterior ocular inflammation after extracapsular cataract extraction (ECCE) and intraocular lens (IOL) implantation in this multicenter, double-masked, randomized study. Four of...
journal_title：Ophthalmology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/s0161-6420(88)33034-4
更新日期：1988-09-01 00:00:00
