Abstract:
PURPOSE:To assess the prevalence of subretinal drusenoid deposits (SDD) in older adults with healthy maculas and early and intermediate age-related macular degeneration (AMD) using multimodal imaging. DESIGN:Cross-sectional study. PARTICIPANTS:A total of 651 subjects aged ≥60 years enrolled in the Alabama Study of Early Age-Related Macular Degeneration from primary care ophthalmology clinics. METHODS:Subjects were imaged using spectral domain optical coherence tomography (SD OCT) of the macula and optic nerve head (ONH), infrared reflectance, fundus autofluorescence, and color fundus photographs (CFP). Eyes were assessed for AMD presence and severity using the Age-Related Eye Disease Study (AREDS) 9-step scale. Criteria for SDD presence were identification on ≥1 en face modality plus SD OCT or on ≥2 en face modalities if absent on SD OCT. Subretinal drusenoid deposits were considered present at the person level if present in 1 or both eyes. MAIN OUTCOME MEASURES:Prevalence of SDD in participants with and without AMD. RESULTS:Overall prevalence of SDD was 32% (197/611), with 62% (122/197) affected in both eyes. Persons with SDD were older than those without SDD (70.6 vs. 68.7 years, P = 0.0002). Prevalence of SDD was 23% in subjects without AMD and 52% in subjects with AMD (P < 0.0001). Among those with early and intermediate AMD, SDD prevalence was 49% and 79%, respectively. After age adjustment, those with SDD were 3.4 times more likely to have AMD than those without SDD (95% confidence interval, 2.3-4.9). By using CFP only for SDD detection per the AREDS protocol, prevalence of SDD was 2% (12/610). Of persons with SDD detected by SD OCT and confirmed by at least 1 en face modality, 47% (89/190) were detected exclusively on the ONH SD OCT volume. CONCLUSIONS:Subretinal drusenoid deposits are present in approximately one quarter of older adults with healthy maculae and in more than half of persons with early to intermediate AMD, even by stringent criteria. The prevalence of SDD is strongly associated with AMD presence and severity and increases with age, and its retinal topography including peripapillary involvement resembles that of rod photoreceptors. Consensus on SDD detection methods is recommended to advance our knowledge of this lesion and its clinical and biologic significance.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Zarubina AV,Neely DC,Clark ME,Huisingh CE,Samuels BC,Zhang Y,McGwin G Jr,Owsley C,Curcio CAdoi
10.1016/j.ophtha.2015.12.034subject
Has Abstractpub_date
2016-05-01 00:00:00pages
1090-100issue
5eissn
0161-6420issn
1549-4713pii
S0161-6420(15)01558-4journal_volume
123pub_type
杂志文章相关文献
OPHTHALMOLOGY文献大全abstract::A 13-year-old boy presented with a 2-month history of swelling of the right upper eyelid and displacement of the right eye. Computed tomography (CT) showed a tumor in the right orbit and a large osteolytic defect of the orbital frontal bone. At surgery a yellowish-tan mass was found replacing the orbital roof and abut...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(87)33352-4
更新日期:1987-08-01 00:00:00
abstract:PURPOSE:To analyze the visual outcome, systemic associations, effectiveness of treatment, and predicting features of 104 scleritis patients. DESIGN:Retrospective case series. PARTICIPANTS:One hundred four patients treated for scleritis at the University Medical Centers of Groningen and Utrecht, The Netherlands. METH...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2012.08.005
更新日期:2013-02-01 00:00:00
abstract:PURPOSE:This study was performed to determine the long-term efficacy, safety, and stability of noncontact holmium:yttrium aluminum garnet (Ho:YAG) laser thermal keratoplasty (LTK) for correction of low-to-moderate hyperopia. METHODS:The authors treated 1 eye each of 28 patients for correction of low-to-moderate hypero...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章
doi:10.1016/s0161-6420(97)30003-7
更新日期:1997-11-01 00:00:00
abstract::Corneal sensitivity was tested in 145 cases of clear corneal transplants using Cochet-Bonnet aesthesiometer. The central area of corneal transplants was found to be either completely anesthetic or markedly hypesthetic even 32 years following corneal transplantation, as exemplified in a patient who had surgery for kera...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(85)33857-5
更新日期:1985-10-01 00:00:00
abstract:OBJECTIVE:To report the incidence of macular hole reopening after initial successful surgery. DESIGN:A noncomparative retrospective case series. PARTICIPANTS:From a series of 137 consecutive cases of idiopathic macular holes operated on between August 1993 and May 1996, the authors analyzed the charts of 116 cases of...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(99)00182-7
更新日期:2000-04-01 00:00:00
abstract:PURPOSE:The identification of healthy persons more susceptible to dry eye (DED) symptoms developing after surgery remains an unmet need. We performed this study to build a new Ocular Surface Frailty Index (OSFI) and assess its predictive value for DED symptom onset after cataract surgery. DESIGN:Single-center, observa...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2019.12.012
更新日期:2020-07-01 00:00:00
abstract:OBJECTIVE:To report an unusual case of Whipple's disease, including uveitis, seronegative spondylarthropathy, meningitis, and lymphadenopathy, associated with an Arthrobacter sp. infection. DESIGN:Interventional case report. PATIENT AND INTERVENTION:A 60-year-old white man presenting with severe chronic uveitis and s...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/S0161-6420(98)91036-3
更新日期:1998-10-01 00:00:00
abstract:PURPOSE:To provide an initial assessment of the safety of a recombinant adeno-associated virus vector expressing RPE65 (rAAV2-CB-hRPE65) in adults and children with retinal degeneration caused by RPE65 mutations. DESIGN:Nonrandomized, multicenter clinical trial. PARTICIPANTS:Eight adults and 4 children, 6 to 39 years...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/j.ophtha.2016.03.003
更新日期:2016-07-01 00:00:00
abstract:PURPOSE:To analyze the use of the Cutler-Beard transmarginal rotation entropion clamp (Karl Ilg & Co., St. Charles, IL) in patients undergoing the Cutler-Beard procedure for repair of eyelid defects after tumor excision or trauma. DESIGN:Prospective, noncomparative case series. PARTICIPANTS:Twenty-five patients under...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/S0161-6420(02)01995-4
更新日期:2003-04-01 00:00:00
abstract:BACKGROUND:A near-total shift to cataract extraction on an outpatient basis occurred as a result of an administrative ruling by the Health Care Financing Administration. No national study has been conducted to assess the possible effects of that decision on clinical outcomes of surgery. The authors compared the rates o...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(13)31251-2
更新日期:1994-01-01 00:00:00
abstract:OBJECTIVE:This study aimed to examine the characteristics of intraretinal changes associated with macular holes and epiretinal membranes by scanning retinal thickness analysis. STUDY DESIGN:The study design was a nonconsecutive case series. PATIENTS:Fifty-six eyes of patients who had either a suspected or clinically ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(98)91274-x
更新日期:1998-01-01 00:00:00
abstract:PURPOSE:To investigate if previous intravitreal therapy is a predictor of posterior capsule rupture (PCR) during cataract surgery. DESIGN:Multicenter, national electronic medical record (EMR) database study with univariate and multivariate regression modeling. PARTICIPANTS:A total of 65 836 eyes of 44 635 patients un...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ophtha.2016.02.014
更新日期:2016-06-01 00:00:00
abstract:PURPOSE:To investigate the adherence of one clinically relevant ocular isolate of Staphylococcus epidermidis to polymethyl methacrylate (PMMA) and Acrysof (Alcon Surgical, Fort Worth, TX) intraocular lenses (IOLs). DESIGN:Experimental study. PARTICIPANTS:The authors examined the in vitro adherence of one clinically r...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(00)00080-4
更新日期:2000-06-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to determine objectively the changes in optical aberrations induced by the progressive tear film irregularity after a blink and their effects on retinal image quality. DESIGN:Prospective, consecutive, nonrandomized comparative trial (self-controlled). PARTICIPANTS:Twenty health...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章
doi:10.1016/j.ophtha.2003.06.027
更新日期:2004-04-01 00:00:00
abstract::A prospective randomized trial was carried out during the years 1974 to 1981 to determine whether preoperative antibiotic soaking of silicone sponges used in retinal detachment surgery would reduce the incidence of postoperative infection and extrusion. During this period 2972 consecutive primary scleral buckles were ...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章
doi:10.1016/s0161-6420(84)34105-7
更新日期:1984-12-01 00:00:00
abstract::A retrospective evaluation of 100 patients who wore disposable extended-wear contact lenses is presented. The patients were selected at random and were fitted with one of three lens brands approved for extended wear. There were 37 males and 63 females in the study. The mean age was 40.1 years (range, 14 to 76 years). ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(91)32068-2
更新日期:1991-11-01 00:00:00
abstract:PURPOSE:Assess the impact of false-positives (FP), false-negatives (FN), fixation losses (FL), and test duration (TD) on visual field (VF) reliability at different stages of glaucoma severity. DESIGN:Retrospective. PARTICIPANTS:A total of 10 262 VFs from 1538 eyes of 909 subjects with suspect or manifest glaucoma and...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2017.04.035
更新日期:2017-11-01 00:00:00
abstract:PURPOSE:To use in vivo confocal microscopy (IVCM) to quantitatively analyze microstructural changes over time, after corneal collagen cross-linking for keratoconus. DESIGN:Prospective cohort study. PARTICIPANTS:A total of 38 eyes of 38 patients undergoing collagen cross-linking for keratoconus. METHODS:Prospective, ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2013.09.014
更新日期:2014-02-01 00:00:00
abstract::Four cases are presented that illustrate a wide spectrum of ophthalmologic and systemic features of necrobiotic xanthogranuloma (NXG). Case 1 initially had signs of Cogan syndrome, and then developed chronic lymphocytic leukemia. Case 2, the first case of NXG to undergo autopsy, had progressive cicatricial lid retract...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(92)32031-7
更新日期:1992-01-01 00:00:00
abstract:PURPOSE:To compare the cost of phacoemulsification with foldable lenses with that of manual small-incision cataract surgery (SICS) in a hospital setting. DESIGN:Average cost comparision between 2 surgical techniques. PARTICIPANTS:Four hundred patients and 4 surgeons. METHODS:A single masked randomized controlled cli...
journal_title:Ophthalmology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ophtha.2006.08.057
更新日期:2007-05-01 00:00:00
abstract::The Prospective Evaluation of Radial Keratotomy (PERK) study is a nine-center clinical trial of a standardized technique of radial keratotomy in 435 patients who had simple myopia with a preoperative refractive error between -2.00 and -8.00 diopters (D). The authors report results for one eye of each patient. The surg...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(87)80021-0
更新日期:1987-10-01 00:00:00
abstract:PURPOSE:To ascertain the clinical features, visual outcome, and recurrence rates of ocular toxoplasmosis (OT) in a large series of patients. To determine the efficacy of various treatment strategies and identify the patients at risk of visual loss. DESIGN:Retrospective noncomparative observational case series. PARTIC...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(02)00990-9
更新日期:2002-05-01 00:00:00
abstract:OBJECTIVE:To investigate microstructures in patients with genetically confirmed Bowman's layer dystrophies (Thiel-Behnke or Reis-Bücklers corneal dystrophy) using an in vivo laser scanning confocal microscope. DESIGN:Single-center, prospective, comparative small case series. PARTICIPANTS:Two patients from one pedigre...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2006.05.076
更新日期:2007-01-01 00:00:00
abstract:PURPOSE:To prospectively examine the change in upper eyelid position on downgaze in patients with blepharoptosis. METHODS:Upper eyelid margin to corneal light reflex distance (uMRD) was measured in primary gaze and in 30 degrees to 40 degrees downgaze in 50 consecutive patients with acquired ptosis and 10 consecutive ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(95)30837-8
更新日期:1995-10-01 00:00:00
abstract:PURPOSE:To determine whether intravitreal triamcinolone acetonide (IVTA) improves the efficacy of photodynamic therapy (PDT) with verteporfin in predominantly classic subfoveal choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD). DESIGN:Prospective randomized study. PARTICIPANTS:Six...
journal_title:Ophthalmology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ophtha.2006.04.039
更新日期:2006-12-01 00:00:00
abstract:OBJECTIVE:The authors compared two methods, the Marcus Gunn test and the alternating light test, for detecting a relative afferent pupillary defect. DESIGN:A randomized, prospective clinical trial. PARTICIPANTS:Fourteen patients with unilateral optic neuropathy. INTERVENTION:The Marcus Gunn and alternating light tes...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/S0161-6420(98)95029-1
更新日期:1998-05-01 00:00:00
abstract::An entire family (father, mother, and three daughters) were given thiabendazole because one of the children had acquired pinworm infestation. The mother and one daughter (non-infected) developed a sicca complex (keratoconjunctivitis sicca and xerostomia) accompanied by cholangiostatic jaundice. Sjögren's syndrome is a...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(79)35334-9
更新日期:1979-10-01 00:00:00
abstract:OBJECTIVE:This study aimed to establish a practical diagnostic test for choroideremia (CHM) and to show its application in a family with the clinical diagnosis of choroideremia. DESIGN:Case series. PARTICIPANTS:Sixteen males from 13 families with clinically documented CHM and unaffected normal males were enrolled in ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/S0161-6420(98)99031-5
更新日期:1998-09-01 00:00:00
abstract:OBJECTIVE:To determine the outcome of pediatric dacryocystorhinostomy (DCR) for large mucoceles or for primary nasolacrimal duct obstruction unresponsive to multiple probings. DESIGN:Retrospective noncomparative case series. PARTICIPANTS:One hundred thirty-four external dacryocystorhinostomies were performed in 121 c...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(01)00699-6
更新日期:2001-09-01 00:00:00
abstract::A temporary apposition of retina and choroid has been created during retinal detachment surgery by injection of sodium hyaluronate into the suprachoroidal space in 14 patients. The iatrogenic choroidal detachment lasts at least seven to ten days, allowing adequate time for retinopexy to permanently seal the retinal ho...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(86)33553-x
更新日期:1986-11-01 00:00:00