Abstract：
:Perfluoropropane (C3F8) was injected into nine eyes of six cynomolgus monkeys. In all nine eyes, macular changes consistent with the development of a macular cyst were noted within 3 months after injection. On fluorescein angiography, there was no evidence of retinal vascular leakage associated with the macular cysts. Histopathologic evaluation of six eyes demonstrated microcystic changes throughout the perifoveal inner nuclear layer. These coalesced into larger cystic spaces in the outer plexiform layer of the central macula. These macular changes are previously unreported in patients or monkeys undergoing intravitreal injection of expansile gases. This model for macular cysts may be helpful in evaluating the pathogenesis and role of interventional strategies in patients with cystoid macular edema.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Repka MX,Bressler NM,D'Anna SAdoi
10.1016/s0161-6420(91)32259-0subject
Has Abstractpub_date
1991-04-01 00:00:00pages
535-40issue
4eissn
0161-6420issn
1549-4713pii
S0161-6420(91)32259-0journal_volume
98pub_type
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