Abstract：
:Marihuana inhalation was accompanied by increased heart rate and decreased intraocular and blood pressure in 18 subjects with heterogenous glaucomas. The hypotensive effects appeared in 60 to 90 minutes as the decrease in intraocular pressure (IOP) appeared to follow the decrease in blood pressure. In addition to any local effect, the mechanism of lowered to any local effect, the mechanism of lowered IOP may also involve the decreased pressure perfusing the ciliary body vasculature as a result of the peripheral vasodilatory properties of marihuana. Postural hypotension, tachycardia, palpitations, and alterations in mental status occurred with such frequency as to mitigate against the routine used in the general glaucoma population. Our data indicate that further research should be directed to local means of delivering the ocular hypotensive cannabinoid to the glaucomatous eye.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Merritt JC,Crawford WJ,Alexander PC,Anduze AL,Gelbart SSdoi
10.1016/s0161-6420(80)35258-5subject
Has Abstractpub_date
1980-03-01 00:00:00pages
222-8issue
3eissn
0161-6420issn
1549-4713pii
S0161-6420(80)35258-5journal_volume
87pub_type
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