Evaluation of the t test as a method of detecting visual field changes.


:Automated perimetry is used to monitor changes associated with many ocular conditions such as glaucoma, neuro-ophthalmologic disorders, and retinal diseases. Comparisons among sequential visual fields are crucial to the determination of progression or regression of ocular anomalies, and to evaluate the efficacy of various therapeutic regimens. The Delta program for the Octopus perimeter uses a t test to provide an objective comparison of visual fields. To evaluate the utility of the t test for detecting visual field changes, the authors used computer simulation to generate pairs of visual fields with known alterations, and made comparisons with the t test procedure used by the Delta program. An initial visual field based on normal data was produced and stored. A second visual field, based on the same normal data but with a scotoma of known size and depth, was also produced and stored. A t test (as used by the Delta program) was then used to compare the two visual fields for statistically significant differences. Our results indicate that the t test was very sensitive to small changes of the entire visual field, such as those produced by both pathologic and nonpathologic (day-to-day sensitivity variations, changes in pupil size, etc.) factors. However, the t test was unable to reliably detect small to moderate scotomata (less than or equal to 18 degrees in diameter), even when the sensitivity loss was greater than 35 dB. These findings suggest that the t test has limited clinical utility for objective detection of pathologic visual field loss, and that additional procedures may be necessary to provide reliable detection of visual field changes.






Hills JF,Johnson CA




Has Abstract


1988-02-01 00:00:00














  • The Fyodorov Sputnik intraocular lens.

    abstract::The author has implanted 197 Fyodorov intraocular lenses. With careful selection of patients, good surgical judgment, and meticulous surgery, a degree of success can be obtained with this lens, which will equal that of conventional cataract surgery. The surgical technique of implantation will be described. ...


    pub_type: 杂志文章


    authors: Kwitko ML

    更新日期:1979-04-01 00:00:00

  • Evaluation of Femtosecond Laser Intrastromal Incision Location Using Optical Coherence Tomography.

    abstract:PURPOSE:To use optical coherence tomography (OCT) to evaluate the femtosecond laser intrastromal incisions made during cataract surgery to reduce corneal astigmatism. DESIGN:Retrospective case series. PARTICIPANTS:Seventy-seven eyes of 77 patients. METHODS:Paired intrastromal incisions were created using the Catalys...


    pub_type: 杂志文章


    authors: Wang L,Jiang L,Hallahan K,Al-Mohtaseb ZN,Koch DD

    更新日期:2017-08-01 00:00:00

  • The Red Badge.

    abstract::This article discusses the experience of progressing from a young ophthalmic resident to a full-time professional and, ultimately, to service on the American Board of Ophthalmology. ...


    pub_type: 杂志文章


    authors: Alward WL

    更新日期:2016-09-01 00:00:00

  • Responsiveness of health-related quality-of-life questionnaires in adults undergoing Strabismus surgery.

    abstract:OBJECTIVE:To evaluate the responsiveness of 2 health-related quality-of-life (HRQOL) questionnaires, the Adult Strabismus-20 (AS-20) and National Eye Institute Visual Function Questionnaire-25 (VFQ-25), to changes in HRQOL after strabismus surgery. DESIGN:Cohort study. PARTICIPANTS:We included 106 adults (aged 18-84 ...


    pub_type: 杂志文章


    authors: Hatt SR,Leske DA,Holmes JM

    更新日期:2010-12-01 00:00:00

  • Intrapapillary hemorrhage with adjacent peripapillary subretinal hemorrhage.

    abstract:PURPOSE:To describe the clinical features and to present results of new diagnostic methods to help define the cause of the clinical syndrome of intrapapillary hemorrhage with adjacent peripapillary subretinal hemorrhage (IHAPSH). DESIGN:Retrospective review of patients with IHAPSH at presentation seen in 3 centers in ...


    pub_type: 杂志文章


    authors: Kokame GT,Yamamoto I,Kishi S,Tamura A,Drouilhet JH

    更新日期:2004-05-01 00:00:00

  • Diabetes can alter the interpretation of visual dysfunction in ocular hypertension.

    abstract:PURPOSE:The authors examined the influences of diabetes on the results of visual function testing in patients with ocular hypertension (OHT). METHODS:Color vision (desaturated D-15), contrast sensitivity together with both transient and steady-state pattern electroretinogram (PERG) findings from patients with document...


    pub_type: 杂志文章


    authors: Vesti E,Trick GL

    更新日期:1996-09-01 00:00:00

  • Oculopalatal myoclonus after the one-and-a-half syndrome with facial nerve palsy.

    abstract:PURPOSE:The one-and-a-half syndrome is an eye movement disorder characterized by a unilateral gaze palsy and an ipsilateral internuclear ophthalmoplegia. The authors describe a previously unrecognized association between the one-and-a-half syndrome and oculopalatal myoclonus (OPM). METHODS:Five clinical cases are pres...


    pub_type: 杂志文章


    authors: Wolin MJ,Trent RG,Lavin PJ,Cornblath WT

    更新日期:1996-01-01 00:00:00

  • Establishing analysis parameters for spherical aberration after wavefront LASIK.

    abstract:PURPOSE:To compare preoperative and postoperative spherical aberration, coma, and other higher order aberrations from wavefront LASIK at varying pupil analysis diameters and different myopic corrections, and to determine acceptable parameters for wavefront measurements. DESIGN:Nonrandomized retrospective chart review....


    pub_type: 杂志文章


    authors: Hiatt JA,Grant CN,Boxer Wachler BS

    更新日期:2005-06-01 00:00:00

  • Hyperbaric oxygen therapy for beta-radiation-induced scleral necrosis.

    abstract:BACKGROUND:Beta-radiation has been used since 1950 as a postoperative measure to reduce the recurrence of pterygia. Scleral necrosis has been a major complication after radiotherapy that has led to perforation of the globe, endophthalmitis, and visual loss in some cases. METHOD:A patient is presented in whom scleral n...


    pub_type: 杂志文章


    authors: Green MO,Brannen AL

    更新日期:1995-07-01 00:00:00

  • Long-term follow-up of Intacs for post-LASIK corneal ectasia.

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    pub_type: 杂志文章


    authors: Kymionis GD,Tsiklis NS,Pallikaris AI,Kounis G,Diakonis VF,Astyrakakis N,Siganos CS

    更新日期:2006-11-01 00:00:00

  • Learning Curve in Descemet's Membrane Endothelial Keratoplasty: First Series of 135 Consecutive Cases.

    abstract:PURPOSE:To evaluate the learning curve in Descemet's membrane endothelial keratoplasty (DMEK) in the management of corneal endothelial disorders. DESIGN:Retrospective, nonrandomized, clinical study at a tertiary referral center. PARTICIPANTS:We included 135 eyes of 118 patients with Fuchs' endothelial dystrophy. MET...


    pub_type: 临床试验,杂志文章


    authors: Dapena I,Ham L,Droutsas K,van Dijk K,Moutsouris K,Melles GR

    更新日期:2011-11-01 00:00:00

  • Influence of the vitreomacular interface on outcomes of ranibizumab therapy in neovascular age-related macular degeneration.

    abstract:PURPOSE:To investigate the influence of the vitreomacular interface (VMI) on the functional and anatomic efficacy of ranibizumab therapy in patients with neovascular age-related macular degeneration (AMD). DESIGN:Subanalysis of a prospective, 12-month, multicenter, phase IIIb trial. PARTICIPANTS:A total of 353 treatm...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Mayr-Sponer U,Waldstein SM,Kundi M,Ritter M,Golbaz I,Heiling U,Papp A,Simader C,Schmidt-Erfurth U

    更新日期:2013-12-01 00:00:00

  • A new classification of superior oblique palsy based on congenital variations in the tendon.

    abstract:BACKGROUND:Superior oblique palsy is the most frequent isolated cranial nerve palsy seen in strabismus practice. It is traditionally diagnosed according to etiology as acquired, congenital, or idiopathic, but surgical treatment is based on deviation not etiology. Observations at surgery led to speculation that the supe...


    pub_type: 杂志文章


    authors: Helveston EM,Krach D,Plager DA,Ellis FD

    更新日期:1992-10-01 00:00:00

  • The development of microneovascular changes in the iris in pseudoexfoliation of the lens capsule.

    abstract::Iris angiography was performed in 25 cases with unilateral pseudoexfoliation of the lens capsule (PXF) (including two which later became bilateral) to study the development of the microneovascular changes which accompany PXF. Sixteen patients had raised intraocular pressure (IOP) and nine had no rise in IOP in the aff...


    pub_type: 杂志文章


    authors: Brooks AM,Gillies WE

    更新日期:1987-09-01 00:00:00

  • A brief history of ophthalmic publications in America.

    abstract::The recent establishment of a rare book collection as part of the American Academy of Ophthalmology Foundation Museum gives Academy members additional access to an important facet of our ophthalmic heritage. Many 17th and 18th century works, such as those of Cotton Mather and Philip Syng Physick, long remained in manu...


    pub_type: 历史文章,杂志文章


    authors: Albert DM

    更新日期:1986-05-01 00:00:00

  • 5-fluorouracil in combined trabeculectomy and clear-cornea phacoemulsification with posterior chamber intraocular lens implantation. A one-year randomized, controlled clinical trial.

    abstract:PURPOSE:To test the effect of postoperative subconjunctival 5-fluorouracil (5-FU) on the pressure outcome in combined procedure (limbus-based trabeculectomy + clear-cornea phacoemulsification). METHODS:Prospective randomized, controlled clinical trial; n = 24 eyes (24 patients) with concurrent open-angle glaucoma and ...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Gandolfi SA,Vecchi M

    更新日期:1997-02-01 00:00:00

  • Routine histopathologic evaluation of the lacrimal sac during dacryocystorhinostomy: how useful is it?

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    pub_type: 杂志文章


    authors: Bernardini FP,Moin M,Kersten RC,Reeves D,Kulwin DR

    更新日期:2002-07-01 00:00:00

  • Long-term results of an intraoperative adjustable superior oblique tendon suture spacer using nonabsorbable suture for Brown Syndrome.

    abstract:OBJECTIVE:To investigate the long-term surgical outcome of Brown syndrome using an intraoperative adjustable superior oblique (SO) tendon suture spacer. DESIGN:Retrospective case series. PARTICIPANTS:Thirteen patients with congenital unilateral Brown syndrome operated on at the Wolfe Eye Clinic from 2001 through 2007...


    pub_type: 杂志文章


    authors: Suh DW,Oystreck DT,Hunter DG

    更新日期:2008-10-01 00:00:00

  • Ocular presentation of polyarteritis nodosa. Clinical course and management with steroid and cytotoxic therapy.

    abstract:BACKGROUND:Polyarteritis nodosa is a necrotizing vasculitis affecting medium and small-sized arteries throughout the body, including ocular tissues. Untreated polyarteritis nodosa carries a very poor prognosis. Treatment with steroids increases the 5-year survival to 48%, whereas addition of cytotoxic immunosuppressive...


    pub_type: 杂志文章


    authors: Akova YA,Jabbur NS,Foster CS

    更新日期:1993-12-01 00:00:00

  • Normal endothelial cell count range.

    abstract::It was the purpose of this study to determine whether age could be used to predict central endothelial cell count in preoperative cataract patients aged 40 to 90. Three separate series of cell counts on a total of almost 3,000 eyes were performed and analyzed regarding age relationship. Although statistically endothel...


    pub_type: 杂志文章


    authors: Hoffer KJ,Kraff MC

    更新日期:1980-09-01 00:00:00

  • Laboratory evidence of sustained chronic inflammatory reaction in retinitis pigmentosa.

    abstract:PURPOSE:To study the nature of retinal inflammatory response in rd10 mice, an animal model of retinitis pigmentosa (RP), and to investigate the effect of an antioxidant on retinal inflammation and photoreceptor apoptosis. DESIGN:Experimental study. PARTICIPANTS AND CONTROLS:This study included 42 untreated rd10 mice,...


    pub_type: 杂志文章


    authors: Yoshida N,Ikeda Y,Notomi S,Ishikawa K,Murakami Y,Hisatomi T,Enaida H,Ishibashi T

    更新日期:2013-01-01 00:00:00

  • Discoid lupus erythematosus masquerading as chronic blepharoconjunctivitis.

    abstract:PURPOSE:To recognize discoid lupus erythematosus (DLE) as a treatable cause of chronic blepharoconjunctivitis. DESIGN:Retrospective observational case series. PARTICIPANTS:Records of 5 patients with biopsy-proven DLE were reviewed. METHODS:Clinical and pathology records were examined. MAIN OUTCOME MEASURES:Patients...


    pub_type: 杂志文章


    authors: Acharya N,Pineda R 2nd,Uy HS,Foster CS

    更新日期:2005-05-01 00:00:00

  • Recurrent multifocal choroiditis.

    abstract::The authors examined 11 young adult, moderately myopic female patients who presented with visual loss secondary to a newly described disorder consisting of multiple small discrete lesions at the level of the retinal pigment epithelium and choriocapillaris. The condition appears to be inflammatory and occurs primarily ...


    pub_type: 杂志文章


    authors: Morgan CM,Schatz H

    更新日期:1986-09-01 00:00:00

  • Reticular Pseudodrusen in Sorsby Fundus Dystrophy.

    abstract:PURPOSE:To investigate the association of reticular pseudodrusen (RPD) with Sorsby fundus dystrophy (SFD). DESIGN:Prospective, monocenter, cross-sectional case series. SUBJECTS:Sixteen patients of 4 unrelated families with SFD caused by mutations in TIMP3. METHODS:All subjects underwent multimodal imaging including ...


    pub_type: 杂志文章


    authors: Gliem M,Müller PL,Mangold E,Bolz HJ,Stöhr H,Weber BH,Holz FG,Charbel Issa P

    更新日期:2015-08-01 00:00:00

  • Excimer laser smoothing of a reproducible model of anterior corneal surface irregularity.

    abstract::A reproducible model of an irregular corneal surface was developed to test the ability of the excimer laser to treat such surfaces. Using a 193-nm argon fluoride excimer laser set at a fluence of 160 mJ/cm2, repetition rate of 10 Hz, and 185 pulses, fresh de-epithelialized pig eyes underwent phototherapeutic ablations...


    pub_type: 杂志文章


    authors: Fasano AP,Moreira H,McDonnell PJ,Sinbawy A

    更新日期:1991-12-01 00:00:00

  • Real-world assessment of physical activity in glaucoma using an accelerometer.

    abstract:OBJECTIVE:To determine the association between glaucomatous visual field (VF) loss and the amount of physical activity and walking in normal life. DESIGN:Prospective, observational study. PARTICIPANTS:Glaucoma suspects without significant VF or visual acuity loss (controls) and glaucoma subjects with bilateral VF los...


    pub_type: 杂志文章


    authors: Ramulu PY,Maul E,Hochberg C,Chan ES,Ferrucci L,Friedman DS

    更新日期:2012-06-01 00:00:00

  • Argon green (514 nm) versus krypton red (647 nm) modified grid laser photocoagulation for diffuse diabetic macular edema.

    abstract::Between 1984 and 1988, 225 eyes of 132 patients were entered in a prospective, randomized clinical trial to determine if any significant differences exist between treatment with argon green (514 nm) and krypton red (647 nm) modified grid laser photocoagulation for patients with diffuse diabetic maculopathy with or wit...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Olk RJ

    更新日期:1990-09-01 00:00:00

  • Potential acuity meter for predicting visual acuity after Nd:YAG posterior capsulotomy.

    abstract::We studied 30 patients with opacifications of the posterior capsule to determine if the potential acuity meter (PAM) could accurately predict final visual outcome after Nd:YAG discussion. The final visual acuity was within one line of the PAM prediction in 22 of 30 patients (73%), better by two or more lines in seven ...


    pub_type: 杂志文章


    authors: Smiddy WE,Radulovic D,Yeo JH,Stark WJ,Maumenee AE

    更新日期:1986-03-01 00:00:00

  • Dysthyroid optic neuropathy. The crowded orbital apex syndrome.

    abstract::The authors have reviewed the clinical presentation, visual fields, color vision testing, visual-evoked potentials, and computed tomographic (CT) findings of 58 patients (95 eyes) with dysthyroid optic neuropathy. The authors compared these findings to a control group of 60 patients (119 eyes) with thyroid eye disease...


    pub_type: 杂志文章


    authors: Neigel JM,Rootman J,Belkin RI,Nugent RA,Drance SM,Beattie CW,Spinelli JA

    更新日期:1988-11-01 00:00:00

  • Prevalence of Oculo-auriculo-vertebral Spectrum in Dermolipoma.

    abstract:OBJECTIVE:To describe the observed frequency of oculo-auriculo-vertebral spectrum (OAVS) in patients with dermolipoma. DESIGN:Retrospective case series. PARTICIPANTS:Patients with primary presentation of ocular dermolipoma. METHODS:All patients with ocular dermolipoma or lipodermoid were identified from the authors'...


    pub_type: 杂志文章


    authors: Khong JJ,Hardy TG,McNab AA

    更新日期:2013-08-01 00:00:00