Lipoprotein a: where are we now?

Abstract:

PURPOSE OF REVIEW:To provide an update of the literature describing the link between lipoprotein a and vascular disease. RECENT FINDINGS:There is evidence that elevated plasma lipoprotein a levels are associated with coronary heart disease, stroke and other manifestations of atherosclerosis. Several mechanisms may be implicated, including proinflammatory actions and impaired fibrinolysis. SUMMARY:Lipoprotein a potentially represents a useful tool for risk stratification in the primary and secondary prevention setting. However, there are still unresolved methodological issues regarding the measurement of lipoprotein a levels. Targeting lipoprotein a in order to reduce vascular risk is hampered by the lack of well tolerated and effective pharmacological interventions. Moreover, it has not yet been established whether such a reduction will result in fewer vascular events. The risk attributed to lipoprotein a may be reduced by aggressively tackling other vascular risk factors, such as low-density lipoprotein cholesterol.

journal_name

Curr Opin Cardiol

authors

Tziomalos K,Athyros VG,Wierzbicki AS,Mikhailidis DP

doi

10.1097/HCO.0b013e32832ac21a

subject

Has Abstract

pub_date

2009-07-01 00:00:00

pages

351-7

issue

4

eissn

0268-4705

issn

1531-7080

journal_volume

24

pub_type

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