Five decades of pediatric heart transplantation: challenges overcome, challenges remaining.

abstract：PURPOSE OF REVIEW:This review discusses the role of statin therapy in patients with acute coronary syndromes. These drugs modulate endothelial function and stabilize atherosclerotic plaque by inhibiting oxidative stress and inflammation and may provide a relevant clinical benefit in unstable patients. RECENT FINDINGS:...

journal_title：Current opinion in cardiology

authors： Nusca A,Melfi R,Patti G,Di Sciascio G

更新日期：2010-07-01 00:00:00

abstract：:Angiogenesis, the de novo formation of new vasculature, is a critical response to ischemia that provides neovascularization of ischemic tissues. In therapeutic angiogenesis, an angiogen--a mediator that induces angiogenesis--is delivered to targeted tissues, augmenting the native angiogenic process and enhancing reper...

journal_title：Current opinion in cardiology

authors： Hamawy AH,Lee LY,Crystal RG,Rosengart TK

更新日期：1999-11-01 00:00:00

abstract：:A growing number of patients present with heart failure. Some of them may qualify for surgical correction of their cardiac condition. Since heart transplantation will always be available to only a small number of patients, several new surgical techniques have been developed for approval in heart failure patients. Clas...

journal_title：Current opinion in cardiology

authors： Loebe M,Soltero E,Thohan V,Lafuente JA,Noon GP

更新日期：2003-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The efficacy of anticoagulation for valvular prostheses is the result of a delicate balance between the risk of thromboembolic (TE) events and bleeding. Here, we review data on anticoagulation for valve prostheses with a focus on clinical trials that address key unanswered questions. RECENT FINDINGS:...

journal_title：Current opinion in cardiology

authors： Yanagawa B,Whitlock RP,Verma S,Gersh BJ

更新日期：2016-03-01 00:00:00

abstract：:This review describes to date the experience with combined heart-kidney transplant (HNTx) from a single donor. HNTxs are very uncommon relative to single-organ transplants of the heart and kidney, as well as combined kidney-pancreas and combined kidney-liver transplants. Two groups of patients seem to be candidates fo...

journal_title：Current opinion in cardiology

authors： Castillo-Lugo JA,Brinker KR

更新日期：1999-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The emerging role of stress and particularly exercise echocardiography in mitral regurgitation has been recently emphasized. In fact, the evaluation of mitral regurgitation only under resting conditions might underestimate the full impact of the lesion and its clinical effects. RECENT FINDINGS:Exerci...

journal_title：Current opinion in cardiology

authors： Lancellotti P,Magne J

更新日期：2012-09-01 00:00:00

abstract：:The COCPIT study, performed in a complete national cohort of adult patients consecutively listed for cardiac transplantation in Germany in 1997, found a beneficial effect only in the group that was at high risk of dying from heart failure without transplantation. If these results can be reproduced in other countries, ...

journal_title：Current opinion in cardiology

authors： Deng MC,Smits JM,De Meester J,Hummel M,Schoendube F,Scheld HH

更新日期：2001-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Our understanding of the interactions of genes and pathways during heart development continues to expand with our knowledge of the genetic basis of congenital heart disease. Along with the discovery of specific genes that cause lesions, recent research has focused on the interactions of some previousl...

journal_title：Current opinion in cardiology

authors： Wolf M,Basson CT

更新日期：2010-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Truncating variants in the TTN gene (TTNtv) are frequently identified in patients with dilated cardiomyopathy (DCM) but are also present in apparently healthy people in the general population. Consequently, there is considerable uncertainty about what it means for any single individual if a TTNtv is f...

journal_title：Current opinion in cardiology

authors： Fatkin D,Huttner IG

更新日期：2017-05-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize changing paradigms and perceptions in the prevention and treatment of cardiovascular disease. RECENT FINDINGS:Recent studies have shown that arterial inflammation probably plays a key role in the development and progression of atherosclerosis, that acute myocardial infarctions often evol...

journal_title：Current opinion in cardiology

authors： Franklin BA,Trivax JE,Vanhecke TE

更新日期：2008-09-01 00:00:00

abstract：:Over the past year, significant new advances have been made in preventive cardiology. New trials of lipid lowering, estrogen therapy, and hypertension control have added to our understanding of the pathophysiology and prevention of coronary atherosclerosis. This review highlights these new trials and provides insight ...

journal_title：Current opinion in cardiology

authors： Foody JA

更新日期：1999-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Open aortic arch surgery is highly invasive and may result in significant morbidity. Recent innovations in thoracic stent-graft technology have facilitated methods of replacing the aortic arch without deep hypothermic circulatory arrest or even cardiopulmonary bypass. We present a review of the curren...

journal_title：Current opinion in cardiology

authors： Desai ND,Szeto WY

更新日期：2009-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Hypertension and dyslipidemia frequently coexist, and endothelial dysfunction is associated with the pathophysiology of both atherosclerosis and hypertension. Evidence is convincing for an overlapping role of oxidative stress, renin-angiotensin system activation, and dyslipidemia in the genesis of end...

journal_title：Current opinion in cardiology

authors： Sarkar K,Sinha AK,Mehta JL

更新日期：2006-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Atrial fibrillation is an important cause of morbidity in the aging population. The mechanisms responsible for the triggering and maintenance of the chaotic atrial rhythm are still poorly understood. In this review, we will focus on the genetic aspects of atrial fibrillation, to understand causality, ...

journal_title：Current opinion in cardiology

authors： Pérez-Serra A,Campuzano O,Brugada R

更新日期：2017-05-01 00:00:00

abstract：:Several investigators have identified the pulmonary vein as the most common initiator of atrial fibrillation, and isolation of the pulmonary vein from atrial tissue can cure approximately 70% of patients with paroxysmal atrial fibrillation. Ongoing trials of a new device may increase the success rate and decrease the ...

journal_title：Current opinion in cardiology

authors： Tsai CF,Tai CT,Chen SA

更新日期：2003-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Frequent media reports of sudden cardiac arrest or death (SCA/SCD) keep alive a debate as to how best to prevent these tragedies. Several new studies in the past 2 years serve as an impetus to reframe the debate into a reasonable discussion that seeks to obtain more evidence wherever needed and to dev...

journal_title：Current opinion in cardiology

authors： Vetter VL,Dugan NP

更新日期：2013-03-01 00:00:00

abstract：:In this paper, we review literature from June 1990 through May 1991. We discuss normal anatomy and physiology of the proximal coronary arteries, anomalous origin of the coronary arteries from an inappropriate aortic sinus, and anomalous origin of the left coronary artery from the pulmonary artery. Other topics revie...

journal_title：Current opinion in cardiology

authors： Yacoub M,Pepper J

更新日期：1991-12-01 00:00:00

abstract：PURPOSE OF REVIEW:C-reactive protein, a nonspecific marker of inflammation, has recently been proposed both as a marker of low-grade inflammation involved in atherogenesis and as a predictor of disease progression. RECENT FINDINGS:The physiologic functions of C-reactive protein as an anti-inflammatory scavenger molecu...

journal_title：Current opinion in cardiology

authors： Sepulveda JL,Mehta JL

更新日期：2005-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this review is to update the cardiovascular clinician on the current status of surgical therapies aimed at achieving reverse ventricular remodeling. RECENT FINDINGS:Relevant research focusing on mechanical options for reverse ventricular remodeling will be referenced and summarized. SUMMA...

journal_title：Current opinion in cardiology

authors： McGee EC,Gillinov AM,McCarthy PM

更新日期：2006-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this review is to focus specifically on the indications, evolution of technique, and results of surgical ablation for atrial fibrillation. RECENT FINDINGS:With the introduction of the Cox-Maze IV procedure utilizing bipolar radiofrequency ablation and cryoablation, long-term studies have d...

journal_title：Current opinion in cardiology

authors： Lawrance CP,Henn MC,Damiano RJ Jr

更新日期：2015-01-01 00:00:00

abstract：:With marked improvements in stent technology as adjunct to balloon angioplasty for multivessel coronary disease, several newer trials are currently in progress reviewing the optimal revascularization strategy. This review provides background from older studies and addresses the current progress and design of these new...

journal_title：Current opinion in cardiology

authors： Bakhai A,Stables RH,Prasad S,Sigwart U

更新日期：2000-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Thrombus formation, usually on a ruptured atherosclerotic plaque, is pivotal in the pathogenesis of ST segment elevation myocardial infarction (STEMI). This thrombus formation provides the milieu for re-occlusion of the infarct-related artery, the main location of re-infarction post-STEMI. Although ra...

journal_title：Current opinion in cardiology

authors： French JK,Burgess S,Chew DP

更新日期：2015-07-01 00:00:00

abstract：:There has been an intensive effort in the past year to identify immunologic and nonimmunologic factors in the pathogenesis of cardiac allograft vasculopathy. Significant progress has been made regarding cell proliferation and cell death, with particular focus on cell growth factors, cell death factors, and their recep...

journal_title：Current opinion in cardiology

authors： Dong C,Redenbach D,Wood S,Battistini B,Wilson JE,McManus BM

更新日期：1996-03-01 00:00:00

abstract：:Evaluation of the hemodynamic response in heart failure is a useful adjunct in clinical management. Invasive monitoring has been the accepted gold standard of hemodynamic assessment but carries with it significant associated risks. Noninvasive hemodynamic assessment in heart failure previously has been either unreliab...

journal_title：Current opinion in cardiology

authors： Rosenberg P,Yancy CW

更新日期：2000-05-01 00:00:00

abstract：PURPOSE OF REVIEW:This review aims to summarize recent reports on percutaneous coronary intervention (PCI) strategies for patients with ST-elevation myocardial infarction (STEMI) and multivessel coronary artery disease (CAD). RECENT FINDINGS:Recent randomized clinical trials and meta-analyses have suggested that patie...

journal_title：Current opinion in cardiology

authors： Thomas MP,Bates ER

更新日期：2017-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Transseptal endocardial left-ventricular pacing has a number of potential advantages over left-ventricular epicardial pacing from the coronary sinus, for implantation of cardiac resynchronization therapy (CRT) devices. In this study we review the risks and potential benefits. RECENT FINDINGS:Permanen...

journal_title：Current opinion in cardiology

authors： Whinnett Z,Bordachar P

更新日期：2012-01-01 00:00:00

abstract：PURPOSE OF REVIEW:As the number of people living with heart failure continues to grow, future treatments will focus on efficient donor organ donation and ensuring safe and durable outcomes. This review will focus on organ procurement, graft surveillance and emerging therapies. RECENT FINDINGS:Preliminary studies into ...

journal_title：Current opinion in cardiology

authors： Hasan R,Ela AAE,Goldstein D

更新日期：2017-05-01 00:00:00

abstract：PURPOSE OF REVIEW:In recent decades, the physiology and late outcomes of the Fontan circulation have become better characterized and interest has turned to interventions that might improve exercise capacity and clinical sequelae. No therapy has currently been shown to be more effective for improving exercise capacity i...

journal_title：Current opinion in cardiology

authors： Cordina R,d'Udekem Y

更新日期：2019-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review is to survey the contemporary literature surrounding congenital anomalies of origin of the coronary arteries and to identify remaining gaps in knowledge. RECENT FINDINGS:In recent years, lineage tracing analyses and mechanistic studies in model organisms have enhanced our u...

journal_title：Current opinion in cardiology

authors： Mazine A,Fernandes IM,Haller C,Hickey EJ

更新日期：2019-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Atrial fibrillation after cardiac surgery is associated with adverse outcomes and increased costs. Accordingly, therapy should be provided to prevent postoperative atrial fibrillation. The evaluation of therapies to do so is an area of active investigation with significant recent advances. The purpose...

journal_title：Current opinion in cardiology

authors： Mitchell LB

更新日期：2007-01-01 00:00:00