Anomalous origins of the coronary arteries: current knowledge and future perspectives.

Abstract:

PURPOSE OF REVIEW:The purpose of this review is to survey the contemporary literature surrounding congenital anomalies of origin of the coronary arteries and to identify remaining gaps in knowledge. RECENT FINDINGS:In recent years, lineage tracing analyses and mechanistic studies in model organisms have enhanced our understanding of the normal embryologic development of the coronary arteries, and how disruption of this intricate process can lead to congenital coronary anomalies. The true incidence of these anomalies remains unknown. Although a majority of cases are believed to be clinically silent, clinical presentation varies widely, from asymptomatic to sudden cardiac death. Cardiac computed tomography angiography and/or magnetic resonance angiography are the mainstay diagnostic modalities. Management of anomalous coronary arteries depends on the morphology and clinical presentation. Surgery is the gold-standard treatment for anomalous left coronary artery arising from the pulmonary artery and anomalous aortic origin of a coronary artery with intramural or interarterial course. SUMMARY:Several large multicenter initiatives are currently underway and should help address some of the numerous knowledge gaps surrounding the evaluation and management of anomalous coronary arteries.

journal_name

Curr Opin Cardiol

authors

Mazine A,Fernandes IM,Haller C,Hickey EJ

doi

10.1097/HCO.0000000000000663

subject

Has Abstract

pub_date

2019-09-01 00:00:00

pages

543-551

issue

5

eissn

0268-4705

issn

1531-7080

journal_volume

34

pub_type

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