The role of statins in endothelial dysfunction in hypertension.


PURPOSE OF REVIEW:Hypertension and dyslipidemia frequently coexist, and endothelial dysfunction is associated with the pathophysiology of both atherosclerosis and hypertension. Evidence is convincing for an overlapping role of oxidative stress, renin-angiotensin system activation, and dyslipidemia in the genesis of endothelial dysfunction. RECENT FINDINGS:Ample experimental and human data suggest that common cellular pathways are involved in the pathogenesis of hypertension, increased vascular resistance, and plaque formation. Multiple interventions such as dietary modification, exercise, antioxidants, and antihypertensive drugs improve endothelial dysfunction in hypertension. Statin drugs are a cornerstone of dyslipidemia therapy. Studies have demonstrated that statins correct endothelial function and vascular stiffening and may be useful in reducing blood pressure to target levels. SUMMARY:Statins may be a useful adjunct in the treatment of hypertension in patients with dyslipidemia and possibly those with normal cholesterol levels.


Curr Opin Cardiol


Sarkar K,Sinha AK,Mehta JL




Has Abstract


2006-07-01 00:00:00














  • The pathogenesis of cardiac allograft vasculopathy.

    abstract::There has been an intensive effort in the past year to identify immunologic and nonimmunologic factors in the pathogenesis of cardiac allograft vasculopathy. Significant progress has been made regarding cell proliferation and cell death, with particular focus on cell growth factors, cell death factors, and their recep...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审


    authors: Dong C,Redenbach D,Wood S,Battistini B,Wilson JE,McManus BM

    更新日期:1996-03-01 00:00:00

  • Drug therapy of chronic heart failure in the elderly: the current state of clinical-trial evidence.

    abstract:PURPOSE OF REVIEW:beta-Blockers, angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, aldosterone receptor antagonists, and digoxin are the most common drug classes used to treat chronic heart failure. We examine current clinical trial evidence concerning heart-failure management in the elderly. ...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审


    authors: Dulin BR,Krum H

    更新日期:2006-07-01 00:00:00

  • Pediatric electrophysiology.

    abstract::Our understanding of pediatric arrhythmias continues to evolve through natural history studies of paroxysmal supraventricular tachycardia, the congenital long QT syndrome, and postoperative atrial and ventricular tachyarrhythmias. The influence of the autonomic nervous system on cardiovascular function may play a rol...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审


    authors: Kanter RJ

    更新日期:1993-01-01 00:00:00

  • The use of electrocardiography as a diagnostic and prognostic tool in coronary artery disease.

    abstract::The ECG is the most widely used noninvasive diagnostic and prognostic test administered to patients with suspected or proven coronary artery disease. When considering appropriate use of the electrocardiogram, physicians need to examine the clinical question being asked, the additional information that can be derived,...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审


    authors: Al-Joundi B,Chaitman BR

    更新日期:1992-08-01 00:00:00

  • Diagnosis and management of low-flow, low-gradient aortic stenosis.

    abstract:PURPOSE OF REVIEW:The severity of low-flow, low-gradient aortic stenosis cases continue to be misunderstood because of challenging diagnosis, and treatment remains complex. We discuss current diagnostic and treatment modalities for low-flow, low-gradient aortic stenosis. RECENT FINDINGS:This article summarizes current...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章


    authors: Salemi A,Hameed I,Khan FM,Gaudino M

    更新日期:2020-03-01 00:00:00

  • Coarctation of the aorta: evaluation and management.

    abstract:PURPOSE OF REVIEW:Coarctation of the aorta is the discrete narrowing of the proximal descending aorta and is the sixth most common lesion in congenital heart disease. Repair of the coarctation can relieve the obstruction, but recurrent coarctation and future aneurysm formation can occur, and a heightened risk of vascul...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审


    authors: Tanous D,Benson LN,Horlick EM

    更新日期:2009-11-01 00:00:00

  • Intra-aortic balloon pump: indications, efficacy, guidelines and future directions.

    abstract:PURPOSE OF REVIEW:The intra-aortic balloon pump (IABP) has been used as a cardiac assist device in various clinical situations since 1968 on the basis of the physiological principles and observational data, with little randomized data until recently. RECENT FINDINGS:Recently published randomized controlled trials (RCT...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审


    authors: Ihdayhid AR,Chopra S,Rankin J

    更新日期:2014-07-01 00:00:00

  • Management of resistant hypertension.

    abstract:PURPOSE OF REVIEW:Resistant hypertension is defined as blood pressure above patient goal despite three different antihypertensive agents at optimal dose including a diuretic. Resistant hypertension is increasingly common issue in clinical practice and it is a major risk factor of cardiovascular disease. RECENT FINDING...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审


    authors: Hasan MA,Stewart MH,Lavie CJ,Ventura HO

    更新日期:2019-07-01 00:00:00

  • Low-density lipoprotein-lowering strategies: target versus maximalist versus population percentile.

    abstract:PURPOSE OF REVIEW:Maximalist low-density lipoprotein (LDL)-lowering strategies such as lowering LDL as much as possible or, alternatively, using the most potent LDL-lowering regimens have become increasingly popular. Almost all attention has focused on the potential advantages of these approaches with little focus on t...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审


    authors: Sniderman AD,De Graaf J,Couture P

    更新日期:2012-07-01 00:00:00

  • Noninvasive imaging of myocardial extracellular matrix for assessment of fibrosis.

    abstract:PURPOSE OF REVIEW:Myocardial fibrosis is a common feature of many cardiomyopathies, including hypertrophic cardiomyopathy. Myocardial fibrosis has been shown to be reversible and treatable with timely intervention. Although early detection and assessment of fibrosis is crucial, adequate diagnostics are still in develop...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审


    authors: Won S,Davies-Venn C,Liu S,Bluemke DA

    更新日期:2013-05-01 00:00:00

  • New advances in class III antiarrhythmic drug therapy.

    abstract::In the past 2 years, significant advances have been made in class III antiarrhythmic drug therapy. In patients with ventricular arrhythmias and implantable cardioverter defibrillators (ICDs), antiarrhythmic agents are increasingly being used as adjunct therapy to decrease the frequency of ICD discharges. Sotalol was r...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审


    authors: Sager PT

    更新日期:2000-01-01 00:00:00

  • Dyslipidemia and cardiovascular changes in children.

    abstract:PURPOSE OF REVIEW:In this review, we firstly highlight the role of dyslipidemia as a trigger in the initiation and progression of endothelial dysfunction, considered the earliest atherosclerotic lesion and patent in children with risk factors.In this context, we also revise methods that reflect the impact of endothelia...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审


    authors: Pires A,Sena C,Seiça R

    更新日期:2016-01-01 00:00:00

  • Lung transplantation in children.

    abstract::Fewer than 50 pediatric lung transplants are performed each year. Surgical advances in the field have resulted in improved operative outcomes and in technical innovations that have broadened both the target population and the donor pool. At the same time, late referral of critically ill patients and shortage of donor ...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审


    authors: Bridges ND

    更新日期:1998-01-01 00:00:00

  • Preventive cardiology in the elderly.

    abstract::Cardiovascular disease is the leading cause of death world-wide in populations older than 65 years of age. The variation in cardiovascular mortality rates in this population indicates a substantial potential for effective coronary prevention. The highest risk for development of coronary heart disease is in individuals...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审


    authors: Wenger NK

    更新日期:1997-03-01 00:00:00

  • Are statins diabetogenic?

    abstract:PURPOSE OF REVIEW:Statins are widely utilized for low-density lipoprotein lowering and for prevention of atherosclerotic cardiovascular disease. Although these drugs have a good safety record, increased risk of developing diabetes during extended use has recently garnered attention. Here we review clinical trial eviden...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审


    authors: Sampson UK,Linton MF,Fazio S

    更新日期:2011-07-01 00:00:00

  • Surgical treatment of coronary artery anomalies.

    abstract::In this paper, we review literature from June 1990 through May 1991. We discuss normal anatomy and physiology of the proximal coronary arteries, anomalous origin of the coronary arteries from an inappropriate aortic sinus, and anomalous origin of the left coronary artery from the pulmonary artery. Other topics revie...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审


    authors: Yacoub M,Pepper J

    更新日期:1991-12-01 00:00:00

  • High-density lipoprotein cholesterol raising: does it matter?

    abstract:PURPOSE OF REVIEW:Cardiovascular disease (CVD) is the leading cause of morbidity and premature mortality in Europe and the United States, and is increasingly common in developing countries. High-density lipoprotein cholesterol (HDL-C) is an independent risk factor for CVD and is superior to low-density lipoprotein chol...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审


    authors: Schofield JD,France M,Ammori B,Liu Y,Soran H

    更新日期:2013-07-01 00:00:00

  • Recent advances in cardiac magnetic resonance imaging.

    abstract::Magnetic resonance imaging of the cardiovascular system is now a well-recognized primary investigative technique for many conditions of structural abnormality in clinical cardiology, but the assessment of functional abnormality is also valuable and is increasingly being recognized by clinicians because of the accuracy...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审


    authors: Taylor AM,Pennell DJ

    更新日期:1996-11-01 00:00:00

  • Innovations in cardiac transplantation.

    abstract:PURPOSE OF REVIEW:As the number of people living with heart failure continues to grow, future treatments will focus on efficient donor organ donation and ensuring safe and durable outcomes. This review will focus on organ procurement, graft surveillance and emerging therapies. RECENT FINDINGS:Preliminary studies into ...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章


    authors: Hasan R,Ela AAE,Goldstein D

    更新日期:2017-05-01 00:00:00

  • Therapy for primary cardiac tumors: is there a role for heart transplantation?

    abstract::Primary cardiac tumors are rare clinical entities. Benign tumors are often amenable to surgical excision, whereas malignant tumors are seldom resectable. The literature has reported that 28 patients have undergone orthotopic heart transplantation for inoperable primary cardiac tumors. The results of these transplants ...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审


    authors: Gowdamarajan A,Michler RE

    更新日期:2000-03-01 00:00:00

  • Transient receptor potential vanilloid channels in hypertension, inflammation, and end organ damage: an imminent target of therapy for cardiovascular disease?

    abstract:PURPOSE OF REVIEW:The possible role of several neurohormonal factors in pathogenesis of hypertension has been studied extensively both in humans and in experimental animal models. However, controversial data from some previous studies are indecisive and call for reassessment and development of new targets. This mini-re...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审


    authors: Wang DH

    更新日期:2008-07-01 00:00:00

  • Pulmonary edema: new insight on pathogenesis and treatment.

    abstract::Pulmonary edema is one of the most serious and life-threatening situations in emergency medicine. Lately it has become apparent that in most cases pulmonary edema is not caused by fluid accumulation but rather fluid redistribution that is directed into the lungs because of heart failure. Based on a series of recently ...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审


    authors: Cotter G,Kaluski E,Moshkovitz Y,Milovanov O,Krakover R,Vered Z

    更新日期:2001-05-01 00:00:00

  • Atrial-fibrillation ablation should be considered first-line therapy for some patients.

    abstract:PURPOSE OF REVIEW:Ablation for atrial fibrillation has become a widely accepted and practiced treatment for this arrhythmia. While this treatment has traditionally been reserved for second-line therapy in patients who have failed drug therapy, ablation is now being contemplated for first-line treatment. This review out...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审


    authors: Verma A

    更新日期:2008-01-01 00:00:00

  • Update on cardiac catheterization and coronary arteriography.

    abstract::Indications for cardiac catheterization--including coronary angiography--have substantially broadened with the advent of nonsurgical therapeutic interventions performed in the catheterization laboratory. Consequently, the increasing number of facilities performing these procedures require clear and unmistakable guidel...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审


    authors: Rafflenbeul W,Riedel M

    更新日期:1993-07-01 00:00:00

  • Genetics of coronary artery disease: should they impact the choice of revascularization?

    abstract:PURPOSE OF REVIEW:Patients with multivessel coronary artery disease (CAD) may undergo revascularization by either percutaneous coronary intervention (PCI) or coronary artery bypass graft surgery (CABG). This review will discuss the use of polygenic risk scores for risk-stratification of patients with multivessel CAD in...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审


    authors: Hui SK,Lindale E,Sun L,Ruel M

    更新日期:2018-11-01 00:00:00

  • Culture, teamwork and engagement: 40 years of finding the right ingredients.

    abstract:PURPOSE OF REVIEW:Changing demands in healthcare, new leadership structures and physician preferences on work-life balance have made culture, teamwork and engagement vitally important for the long-term success of medical practices. With recent emphasis placed on culture, teamwork and engagement, leaders have had to acq...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章


    authors: Samai C,Campbell R

    更新日期:2021-01-01 00:00:00

  • Update of implantable cardioverter/defibrillator and cardiac resynchronization therapy in heart failure.

    abstract:PURPOSE OF REVIEW:Heart failure prevalence is reaching epidemic proportion in the United States and is associated with significant morbidity and mortality. A large proportion of the mortality is the result of sudden cardiac death (SCD). Clinical trials have demonstrated the superiority of the implantable cardioverter/d...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审


    authors: Rami T,Shih HT

    更新日期:2004-05-01 00:00:00

  • Advances in implantable cardioverter defibrillators.

    abstract::Implantable cardioverter defibrillators (ICDs) have become an important therapeutic modality for patients who have had a cardiac arrest or are at risk for life-threatening ventricular arrhythmias. Clinical trials have confirmed the role of the ICD for patients with sustained ventricular arrhythmias and have expanded t...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审


    authors: Swygman C,Wang PJ,Link MS,Homoud MK,Estes NA 3rd

    更新日期:2002-01-01 00:00:00

  • Institutional and national trends in isolated mitral valve surgery over the past decade.

    abstract:PURPOSE OF REVIEW:To review trends in practice for mitral valve surgery in the US over the past decade. RECENT FINDINGS:Advances in the understanding of mitral valve pathophysiology and the technology involved with mitral valve surgery have led to significant changes of the current practice for mitral valve surgery, w...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审


    authors: Ad N,Barnett SD,Speir AM,Massimiano PS

    更新日期:2008-03-01 00:00:00

  • Future pharmacological therapy in hypertension.

    abstract:PURPOSE OF REVIEW:Hypertension (HTN) is a widespread and growing disease, with medication intolerance and side-effect present among many. To address these obstacles novel pharmacotherapy is an active area of drug development. This review seeks to explore future drug therapy for HTN in the preclinical and clinical arena...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审


    authors: Stewart MH,Lavie CJ,Ventura HO

    更新日期:2018-07-01 00:00:00