The role of statins in endothelial dysfunction in hypertension.

Abstract:

PURPOSE OF REVIEW:Hypertension and dyslipidemia frequently coexist, and endothelial dysfunction is associated with the pathophysiology of both atherosclerosis and hypertension. Evidence is convincing for an overlapping role of oxidative stress, renin-angiotensin system activation, and dyslipidemia in the genesis of endothelial dysfunction. RECENT FINDINGS:Ample experimental and human data suggest that common cellular pathways are involved in the pathogenesis of hypertension, increased vascular resistance, and plaque formation. Multiple interventions such as dietary modification, exercise, antioxidants, and antihypertensive drugs improve endothelial dysfunction in hypertension. Statin drugs are a cornerstone of dyslipidemia therapy. Studies have demonstrated that statins correct endothelial function and vascular stiffening and may be useful in reducing blood pressure to target levels. SUMMARY:Statins may be a useful adjunct in the treatment of hypertension in patients with dyslipidemia and possibly those with normal cholesterol levels.

journal_name

Curr Opin Cardiol

authors

Sarkar K,Sinha AK,Mehta JL

doi

10.1097/01.hco.0000231401.87232.71

subject

Has Abstract

pub_date

2006-07-01 00:00:00

pages

316-21

issue

4

eissn

0268-4705

issn

1531-7080

pii

00001573-200607000-00010

journal_volume

21

pub_type

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