Abstract：
PURPOSE OF REVIEW:C-reactive protein, a nonspecific marker of inflammation, has recently been proposed both as a marker of low-grade inflammation involved in atherogenesis and as a predictor of disease progression. RECENT FINDINGS:The physiologic functions of C-reactive protein as an anti-inflammatory scavenger molecule have begun to emerge. For example, C-reactive protein binds to damaged lipoproteins and facilitates their removal by phagocytes without full complement activation. Increased levels of C-reactive protein may result in direct effects on vascular cells, including induction of cytokines and prothrombotic factors. Several sources of biologic variation in the levels of C-reactive protein have been identified, chief among which are abdominal obesity and the metabolic syndrome. Although previous studies showed a potent independent association of C-reactive protein levels with cardiac events, the strength of association was shown to be much weaker than previously reported in recent large meta-analyses. Therapy with nonspecific anti-inflammatory agents such as statins in patients with coronary artery disease has been found to reduce adverse outcomes in association with reductions in C-reactive protein, on the basis of retrospective analysis of stored blood specimens. SUMMARY:Despite a relatively strong epidemiologic association with future adverse cardiovascular events, the great majority of apparently healthy individuals with elevated C-reactive protein will not experience cardiovascular disease. Even though more than 15 000 articles in PubMed mention C-reactive protein, current knowledge is insufficient to implicate C-reactive protein as a causative factor in atherothrombosis or to enable the recommendation of C-reactive protein testing to guide preventive or therapeutic interventions in cardiovascular diseases.
journal_name
Curr Opin Cardioljournal_title
Current opinion in cardiologyauthors
Sepulveda JL,Mehta JLdoi
10.1097/01.hco.0000175518.57804.94subject
Has Abstractpub_date
2005-09-01 00:00:00pages
407-16issue
5eissn
0268-4705issn
1531-7080pii
00001573-200509000-00008journal_volume
20pub_type
杂志文章,评审abstract：:The ECG is the most widely used noninvasive diagnostic and prognostic test administered to patients with suspected or proven coronary artery disease. When considering appropriate use of the electrocardiogram, physicians need to examine the clinical question being asked, the additional information that can be derived,...
journal_title：Current opinion in cardiology
pub_type： 杂志文章,评审
doi：10.1097/00001573-199208000-00008
更新日期：1992-08-01 00:00:00
abstract：PURPOSE OF REVIEW:Lifestyle counseling that includes exercise training, diet modification, and medication adherence is critical to hypertension management. This article summarizes the efficacy of lifestyle counseling interventions in face-to-face, telehealth, and e-counseling settings. It also discusses the therapeutic...
journal_title：Current opinion in cardiology
pub_type： 杂志文章,评审
doi：10.1097/HCO.0000000000000080
更新日期：2014-07-01 00:00:00
abstract：PURPOSE OF REVIEW:This review discusses the role of statin therapy in patients with acute coronary syndromes. These drugs modulate endothelial function and stabilize atherosclerotic plaque by inhibiting oxidative stress and inflammation and may provide a relevant clinical benefit in unstable patients. RECENT FINDINGS:...
journal_title：Current opinion in cardiology
pub_type： 杂志文章,评审
doi：10.1097/HCO.0b013e32833987ca
更新日期：2010-07-01 00:00:00
abstract：:Recent epidemiologic studies of the risk factors for early and late phases of transplant coronary artery disease (TxCAD) have identified metabolic abnormalities such as hyperlipidemia and insulin resistance as important risk factors, independent of rejection. In randomized trials, calcium channel blockers and hydroxym...
journal_title：Current opinion in cardiology
pub_type： 杂志文章,评审
doi：10.1097/00001573-199803000-00007
更新日期：1998-03-01 00:00:00
abstract：PURPOSE OF REVIEW:On the very solid background of experimental and clinical studies pointing to the cardiovascular risks associated with depressed vagal reflexes and supported by specific experiments in animal models of heart failure, we are witnessing a rapidly growing interest in the very untraditional approach to th...
journal_title：Current opinion in cardiology
pub_type： 杂志文章,评审
doi：10.1097/HCO.0b013e3283413961
更新日期：2011-01-01 00:00:00
abstract：:Recent evidence indicates that infections or a pathogen burden contribute to the development and progression of atherosclerosis. While the mechanism of infection contributing to the pathogenesis is not fully elucidated, I hypothesize that heat shock proteins may be a link between infections and atherosclerosis. Heat s...
journal_title：Current opinion in cardiology
pub_type： 杂志文章,评审
doi：10.1097/00001573-200307000-00001
更新日期：2003-07-01 00:00:00
abstract：:The treatment of ischemic heart disease by coronary artery bypass grafting remains under intense scrutiny. A better understanding of the long-term outcome for particular patient subgroups will allow a more appropriate choice to be made among the options of coronary artery bypass grafting, angioplasty, or continued med...
journal_title：Current opinion in cardiology
pub_type： 杂志文章,评审
doi：10.1097/00001573-199611000-00003
更新日期：1996-11-01 00:00:00
abstract：:Implantable cardioverter defibrillators (ICDs) have become an important therapeutic modality for patients who have had a cardiac arrest or are at risk for life-threatening ventricular arrhythmias. Clinical trials have confirmed the role of the ICD for patients with sustained ventricular arrhythmias and have expanded t...
journal_title：Current opinion in cardiology
pub_type： 杂志文章,评审
doi：10.1097/00001573-200201000-00004
更新日期：2002-01-01 00:00:00
abstract：PURPOSE OF REVIEW:Patients with tetralogy of Fallot are subject to arrhythmic sequelae that substantially impact morbidity and mortality. This review focuses on recent advances in our understanding of the prevalence and types of arrhythmias encountered. Diagnostic and prognostic tools are considered and therapeutic opt...
journal_title：Current opinion in cardiology
pub_type： 杂志文章,评审
doi：10.1097/HCO.0b013e328341381a
更新日期：2011-01-01 00:00:00
abstract：:Interest in transmyocardial laser revascularization for the treatment of otherwise inoperable coronary artery disease has increased rather dramatically in recent years. The results of several industrially sponsored clinical series have been reported recently, all with significant improvement in angina pectoris that ap...
journal_title：Current opinion in cardiology
pub_type： 杂志文章,评审
doi：
更新日期：1997-09-01 00:00:00
abstract：PURPOSE OF REVIEW:To compare the potential of high-density lipoprotein (HDL) cholesterol and apolipoprotein (apo) A-I, the major protein in HDL particles, in predicting cardiovascular risk. Pros and cons for using these risk markers are discussed. RECENT FINDINGS:Both HDL cholesterol and apoA-I are in most clinical co...
journal_title：Current opinion in cardiology
pub_type： 杂志文章,评审
doi：10.1097/HCO.0b013e3281bd8849
更新日期：2007-07-01 00:00:00
abstract：PURPOSE OF REVIEW:Transseptal endocardial left-ventricular pacing has a number of potential advantages over left-ventricular epicardial pacing from the coronary sinus, for implantation of cardiac resynchronization therapy (CRT) devices. In this study we review the risks and potential benefits. RECENT FINDINGS:Permanen...
journal_title：Current opinion in cardiology
pub_type： 杂志文章,评审
doi：10.1097/HCO.0b013e32834dc3d4
更新日期：2012-01-01 00:00:00
abstract：PURPOSE OF REVIEW:The goal of this review is to offer an overview of the use of thrombolytic therapy in acute pulmonary embolism. Clinicians including internists, surgeons, pulmonologists, and other specialists continue to face decisions regarding massive and submassive acute pulmonary embolism in their daily routines....
journal_title：Current opinion in cardiology
pub_type： 杂志文章,评审
doi：10.1097/HCO.0b013e328358308c
更新日期：2012-11-01 00:00:00
abstract：PURPOSE OF REVIEW:Since the last few years, three-dimensional echocardiography (3DE) has become an accurate tool for mitral stenosis assessment. We will review the latest developments of 3DE in this matter. RECENT FINDINGS:Accuracy of 3DE planimetry is superior to the accuracy of the invasive Gorlin's method for mitra...
journal_title：Current opinion in cardiology
pub_type： 杂志文章,评审
doi：10.1097/HCO.0b013e32832e165b
更新日期：2009-09-01 00:00:00
abstract：PURPOSE OF REVIEW:Rheumatic heart disease (RHD) affects over 30 million people worldwide. Substantial variation exists in the surgical treatment of patients with RHD. Here, we aim to review the surgical techniques to treat RHD with a focus on rheumatic mitral valve (MV) repair. We introduce novel educational paradigms ...
journal_title：Current opinion in cardiology
pub_type： 杂志文章
doi：10.1097/HCO.0000000000000826
更新日期：2020-12-24 00:00:00
abstract：PURPOSE OF REVIEW:Ticagrelor is a new, direct acting, reversibly binding P2Y12 receptor antagonist with more potent inhibition of platelets than clopidogrel and which does not require metabolic activation. It was compared with clopidogrel, on a background of the standard of care in a randomized trial in the Platelet In...
journal_title：Current opinion in cardiology
pub_type： 杂志文章,随机对照试验
doi：10.1097/HCO.0b013e328353fe7e
更新日期：2012-07-01 00:00:00
abstract：:Cardiopulmonary bypass triggers a generalized inflammatory response that is largely mediated by activation of polymorphonuclear neutrophils, their adhesion to endothelial cells, and the subsequent release of cytotoxic products. It has been known for several years that the inflammatory response to extracorporeal circul...
journal_title：Current opinion in cardiology
pub_type： 杂志文章,评审
doi：
更新日期：1995-11-01 00:00:00
abstract：PURPOSE OF REVIEW:Despite its continued increase in prevalence in minorities, data regarding hypertension (HTN) control among such ethnic groups remains limited. This review highlights the most recent literature on the epidemiology, prevalence, and treatment strategies of HTN among four racial groups (non-Hispanic Whit...
journal_title：Current opinion in cardiology
pub_type： 杂志文章,评审
doi：10.1097/HCO.0000000000000293
更新日期：2016-07-01 00:00:00
abstract：PURPOSE OF REVIEW:Advanced heart failure is a chronic, systemic disease, which affects other organs in ways that are incompletely understood. Patients with advanced heart failure commonly develop congestive hepatopathy, which may lead to progressive hepatic injury and fibrosis. Because the independent adverse effects o...
journal_title：Current opinion in cardiology
pub_type： 杂志文章,评审
doi：10.1097/HCO.0000000000000288
更新日期：2016-05-01 00:00:00
abstract：PURPOSE OF REVIEW:Truncating variants in the TTN gene (TTNtv) are frequently identified in patients with dilated cardiomyopathy (DCM) but are also present in apparently healthy people in the general population. Consequently, there is considerable uncertainty about what it means for any single individual if a TTNtv is f...
journal_title：Current opinion in cardiology
pub_type： 杂志文章
doi：10.1097/HCO.0000000000000382
更新日期：2017-05-01 00:00:00
abstract：PURPOSE OF REVIEW:Despite numerous advances in coronary interventional techniques, the frequent occurrence of restenosis continues to plague interventional cardiology. With the widespread use of drug-eluting stents, there is a need to reexamine critically the roles of the various interventional techniques currently ava...
journal_title：Current opinion in cardiology
pub_type： 杂志文章,评审
doi：10.1097/01.hco.0000133658.77024.59
更新日期：2004-09-01 00:00:00
abstract：PURPOSE OF REVIEW:beta-Blockers, angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, aldosterone receptor antagonists, and digoxin are the most common drug classes used to treat chronic heart failure. We examine current clinical trial evidence concerning heart-failure management in the elderly. ...
journal_title：Current opinion in cardiology
pub_type： 杂志文章,评审
doi：10.1097/01.hco.0000231411.15049.20
更新日期：2006-07-01 00:00:00
abstract：:The therapeutic benefits of angiotensin-converting enzyme inhibitors in the treatment of hypertension, congestive heart failure, and atherosclerotic heart disease are undeniable. Recent studies, however, suggest that the cardioprotective effect produced by these drugs is complex and may not be solely related to inhibi...
journal_title：Current opinion in cardiology
pub_type： 杂志文章,评审
doi：10.1097/00001573-199409000-00004
更新日期：1994-09-01 00:00:00
abstract：PURPOSE OF REVIEW:Radiofrequency ablation techniques to cure cardiac arrhythmias have focused on destroying myocardial tissue involved in abnormal excitation or conduction. This review will address recent basic and clinical studies which suggest that targeting autonomic nerves and ganglia on the large vessels and the h...
journal_title：Current opinion in cardiology
pub_type： 杂志文章,评审
doi：10.1097/01.hco.0000198980.40390.e4
更新日期：2006-01-01 00:00:00
abstract：PURPOSE OF REVIEW:To give an overview over the substantial advances in the diagnosis and management of Long-QT syndrome since its first description 60 years ago. RECENT FINDINGS:LQT syndrome remains the most common inherited arrhythmia and is a leading cause for sudden unexplained death accounting for up to 20-25% of ...
journal_title：Current opinion in cardiology
pub_type： 杂志文章,评审
doi：10.1097/HCO.0000000000000465
更新日期：2018-01-01 00:00:00
abstract：PURPOSE OF REVIEW:The purpose of this article is to provide an overview of investigational work which has demonstrated the ability of MRI to define abnormalities caused by coronary heart disease. There have been numerous recent advances in the MRI assessment of coronary heart disease which warrant review. RECENT FINDI...
journal_title：Current opinion in cardiology
pub_type： 杂志文章,评审
doi：10.1097/HCO.0b013e3283315553
更新日期：2009-11-01 00:00:00
abstract：:Evaluation of the hemodynamic response in heart failure is a useful adjunct in clinical management. Invasive monitoring has been the accepted gold standard of hemodynamic assessment but carries with it significant associated risks. Noninvasive hemodynamic assessment in heart failure previously has been either unreliab...
journal_title：Current opinion in cardiology
pub_type： 杂志文章,评审
doi：10.1097/00001573-200005000-00005
更新日期：2000-05-01 00:00:00
abstract：PURPOSE OF REVIEW:The purpose of this article is to review the strengths and weaknesses of systematic reviews and meta-analyses to inform our current understanding of cardiac surgery. RECENT FINDINGS:A systematic review and meta-analysis of a focused topic can provide a quantitative estimate for the effect of a treatm...
journal_title：Current opinion in cardiology
pub_type： 杂志文章,meta分析
doi：10.1097/HCO.0000000000000496
更新日期：2018-03-01 00:00:00
abstract：:The presence, and in many cases the regulated synthesis, of components of the renin-angiotensin system have been demonstrated in multiple tissues, indicating the existence of tissue angiotensin-generating systems. These vary with respect to which renin-angiotensin system components are synthesized locally and which ar...
journal_title：Current opinion in cardiology
pub_type： 杂志文章,评审
doi：10.1097/00001573-200111000-00002
更新日期：2001-11-01 00:00:00
abstract：:Currently 14 million individuals in the United States have coronary disease. Within the next 2 decades, this number is expected to increase to 21 million persons. To minimize the excessive risk of recurrent cardiac events in these people, evidence-based, cost-effective prevention strategies must be developed. This rev...
journal_title：Current opinion in cardiology
pub_type： 杂志文章,评审
doi：10.1097/00001573-199907000-00005
更新日期：1999-07-01 00:00:00
