A new myocardial conversion of angiotensin I.

Abstract:

:The therapeutic benefits of angiotensin-converting enzyme inhibitors in the treatment of hypertension, congestive heart failure, and atherosclerotic heart disease are undeniable. Recent studies, however, suggest that the cardioprotective effect produced by these drugs is complex and may not be solely related to inhibition of the generation of angiotensin II. An alternative pathway for the generation of angiotensin II from angiotensin I has been proposed, following the recent identification of a chymotrypsin-like protease (chymase) that may contribute to the formation of angiotensin II in human heart tissue. The enzyme is present in cardiac mast cells and displays unusual substrate specificity for the conversion of angiotensin I to angiotensin II. While biochemical studies have provided convincing evidence for a chymase-dependent production of angiotensin II, the contribution of this enzyme to the physiologic or pathological regulation of arterial pressure and cardiac function remains undetermined.

journal_name

Curr Opin Cardiol

authors

Ferrario CM,Chappell MC

doi

10.1097/00001573-199409000-00004

subject

Has Abstract

pub_date

1994-09-01 00:00:00

pages

520-6

issue

5

eissn

0268-4705

issn

1531-7080

journal_volume

9

pub_type

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