Molecular genetics of congenital heart disease.

abstract：PURPOSE OF REVIEW:The number of clinically available genetic tests for heritable cardiovascular diseases has recently increased because of novel gene discoveries and advancements in DNA sequencing technologies. The purpose of this review is to provide up-to-date genetic testing information and guidance on how to incorp...

journal_title：Current opinion in cardiology

authors： Sturm AC,Hershberger RE

更新日期：2013-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The prevention and treatment of rejection have been the major focus of clinical and research studies since the inception of heart transplantation. Recent improvement in survival after transplant has been in large part due to continued advancement in antirejection therapies. RECENT FINDINGS:The combin...

journal_title：Current opinion in cardiology

authors： Chan M,Pearson GJ

更新日期：2007-03-01 00:00:00

abstract：PURPOSE OF REVIEW:In this study, we review the evidence for both long-standing and newer oral antiplatelet agents as secondary prevention in coronary artery disease, and give our opinion on where each agent's treatment role lies. RECENT FINDINGS:Platelets play a pathological role in acute coronary syndromes and are th...

journal_title：Current opinion in cardiology

authors： Behan MW,Chew DP,Aylward PE

更新日期：2010-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Atrial fibrillation is an important cause of morbidity in the aging population. The mechanisms responsible for the triggering and maintenance of the chaotic atrial rhythm are still poorly understood. In this review, we will focus on the genetic aspects of atrial fibrillation, to understand causality, ...

journal_title：Current opinion in cardiology

authors： Pérez-Serra A,Campuzano O,Brugada R

更新日期：2017-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Diagnostic testing using noninvasive imaging has become an integral part of risk stratification in patients with coronary artery disease. It is important to understand the integral strengths and weaknesses between the different modalities of stress testing and to apply accurately the type of test the ...

journal_title：Current opinion in cardiology

authors： Maganti K,Rigolin VH

更新日期：2003-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Changing demands in healthcare, new leadership structures and physician preferences on work-life balance have made culture, teamwork and engagement vitally important for the long-term success of medical practices. With recent emphasis placed on culture, teamwork and engagement, leaders have had to acq...

journal_title：Current opinion in cardiology

authors： Samai C,Campbell R

更新日期：2021-01-01 00:00:00

abstract：:Patients with aortic dissection are divided into two main groups: those with hypertension and those with syndromes involving hereditary defects of the aortic wall. The common finding in the setting of both Marfan syndrome and hypertension is dilatation of the aorta. The biological events that may lead to dissection ar...

journal_title：Current opinion in cardiology

authors： Westaby S

更新日期：1995-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Guidelines indicate surgical intervention for patients with symptomatic severe mitral regurgitation or signs of left ventricular dilatation or dysfunction. However, many patients do not receive surgery because of age or comorbidities, and have poor outcomes with conservative therapy. Transcatheter mit...

journal_title：Current opinion in cardiology

authors： Fam NP,Ross HJ,Verma S

更新日期：2016-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Coronary artery disease is common in patients with end-stage renal disease (ESRD) on hemodialysis. ESRD patients are prone to atherosclerosis and are likely to present with advanced CAD requiring coronary artery bypass graft surgery (CABG) or percutaneous coronary intervention (PCI). RECENT FINDINGS:...

journal_title：Current opinion in cardiology

authors： Karkhanis R,Tam DY,Fremes SE

更新日期：2018-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Cardiac resynchronization therapy (CRT) reduces morbidity and mortality in patients with mild-to-severe heart failure. However, up to 40% of CRT recipients are nonresponders. This review addresses important aspects with regard to the identification and management of CRT nonresponders. RECENT FINDINGS...

journal_title：Current opinion in cardiology

authors： Zhang Q,Zhou Y,Yu CM

更新日期：2015-01-01 00:00:00

abstract：PURPOSE OF REVIEW:With wider indications for implantable cardioverter defibrillator therapy, more patients at lower risk for ventricular tachyarrhythmia receive this treatment. To maintain the ratio of benefit versus side-effects at an acceptable level, the risk of inappropriate implantable cardioverter defibrillator t...

journal_title：Current opinion in cardiology

authors： Israel CW

更新日期：2008-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review is to survey the contemporary literature surrounding congenital anomalies of origin of the coronary arteries and to identify remaining gaps in knowledge. RECENT FINDINGS:In recent years, lineage tracing analyses and mechanistic studies in model organisms have enhanced our u...

journal_title：Current opinion in cardiology

authors： Mazine A,Fernandes IM,Haller C,Hickey EJ

更新日期：2019-09-01 00:00:00

abstract：:Although it has been recognized for almost 70 years that there is a substantial genetic component to the pathogenesis of hypertension, only recently have systematic efforts been made to identify the responsible genetically determined mechanisms. In the case of several rare syndromes, spectacular progress has been made...

journal_title：Current opinion in cardiology

authors： Hollenberg NK

更新日期：1996-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The role of cardiac catheterization in pediatric cardiology has changed significantly in the past 10-15 years. As interventional procedures dominate the field, it is important to examine the recent advances in non-interventional pediatric cardiac catheterization. RECENT FINDINGS:Meaningful and accura...

journal_title：Current opinion in cardiology

authors： Kanter JP,Hellenbrand WE

更新日期：2005-03-01 00:00:00

abstract：:Clinical work in cardiac transplantation has focused on combating the major complications of this procedure, namely graft rejection and infection. Retrospective analyses suggest that prospective HLA typing, as is done in renal transplantation, may improve patient survival. Trials using FK 506 in cardiac transplantati...

journal_title：Current opinion in cardiology

authors： Nisco SJ,Reitz BA

更新日期：1993-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Maximalist low-density lipoprotein (LDL)-lowering strategies such as lowering LDL as much as possible or, alternatively, using the most potent LDL-lowering regimens have become increasingly popular. Almost all attention has focused on the potential advantages of these approaches with little focus on t...

journal_title：Current opinion in cardiology

authors： Sniderman AD,De Graaf J,Couture P

更新日期：2012-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The Brugada syndrome has been investigated in depth since its description in 1992 both on a clinical and on a basic research level. Since the discovery of the first genetic defect in 1998, several genes have been subsequently identified. However, to date all these genes together explain only 30% of th...

journal_title：Current opinion in cardiology

authors： Campuzano O,Brugada R,Iglesias A

更新日期：2010-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Vitamin D deficiency is common throughout the world, with a particularly high prevalence in northern latitudes and colder climates. Although the best known sequelae of vitamin D deficiency involve the musculoskeletal system, a growing body of evidence suggests that vitamin D status may influence cardi...

journal_title：Current opinion in cardiology

authors： Swales HH,Wang TJ

更新日期：2010-09-01 00:00:00

abstract：:Recent data have emerged to help guide the use of implantable pacemakers and implantable defibrillators in patients who have hypertrophic cardiomyopathy (HCM). Controlled studies of the use of dual chamber pacemakers to treat outflow tract obstruction in HCM have shown little benefit, and have raised the possibility t...

journal_title：Current opinion in cardiology

authors： Freedman RA

更新日期：2001-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Dyslipidaemias are noted in all stages of chronic kidney disease (CKD). Currently most evidence for their treatment comes from secondary retrospective analyses of patient subgroups with CKD recruited into clinical trials powered of hypertensive and dyslipideamic cohorts powered for cardiovascular endp...

journal_title：Current opinion in cardiology

authors： Jenkins M,Goldsmith D

更新日期：2012-07-01 00:00:00

abstract：PURPOSE OF REVIEW:C-reactive protein, a nonspecific marker of inflammation, has recently been proposed both as a marker of low-grade inflammation involved in atherogenesis and as a predictor of disease progression. RECENT FINDINGS:The physiologic functions of C-reactive protein as an anti-inflammatory scavenger molecu...

journal_title：Current opinion in cardiology

authors： Sepulveda JL,Mehta JL

更新日期：2005-09-01 00:00:00

abstract：:In this paper, we review literature from June 1990 through May 1991. We discuss normal anatomy and physiology of the proximal coronary arteries, anomalous origin of the coronary arteries from an inappropriate aortic sinus, and anomalous origin of the left coronary artery from the pulmonary artery. Other topics revie...

journal_title：Current opinion in cardiology

authors： Yacoub M,Pepper J

更新日期：1991-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Ticagrelor is a new, direct acting, reversibly binding P2Y12 receptor antagonist with more potent inhibition of platelets than clopidogrel and which does not require metabolic activation. It was compared with clopidogrel, on a background of the standard of care in a randomized trial in the Platelet In...

journal_title：Current opinion in cardiology

authors： Held C

更新日期：2012-07-01 00:00:00

abstract：PURPOSE:New data have emerged over the last few years about the role of fibrates in treatment of microvascular and macrovascular disease. RECENT FINDINGS:Endpoint studies have been conducted with fibrates in coronary heart disease (CHD) since 1971 and initial results were contradictory. Fibrates later showed benefits ...

journal_title：Current opinion in cardiology

authors： Wierzbicki AS

更新日期：2009-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The current article provides a concise summary of the possibilities and limitations of genotype-based risk stratification of cardiac arrhythmias. We will outline the most important findings of the recent years in the light of their chronological and conceptual development. RECENT FINDINGS:Genotype-ph...

journal_title：Current opinion in cardiology

authors： Napolitano C,Mazzanti A,Priori SG

更新日期：2018-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Advanced heart failure is a chronic, systemic disease, which affects other organs in ways that are incompletely understood. Patients with advanced heart failure commonly develop congestive hepatopathy, which may lead to progressive hepatic injury and fibrosis. Because the independent adverse effects o...

journal_title：Current opinion in cardiology

authors： Maltais S,Stulak JM

更新日期：2016-05-01 00:00:00

abstract：:Although significant pharmacologic and nonpharmacologic advances in treating hypertension during the last decade have reduced mortality and morbidity, hypertension continues to be a major health concern worldwide. Therefore, the search continues for newer specific pharmacologic treatment of this disorder. This review ...

journal_title：Current opinion in cardiology

authors： Evans RR,DiPette DJ

更新日期：1997-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Non-invasive testing is often the first step in the evaluation of stable coronary artery disease (CAD). Stress cardiac magnetic resonance imaging (CMR) is an established modality with high diagnostic accuracy and prognostic value. This review will focus on the recent advances in understanding how stre...

journal_title：Current opinion in cardiology

authors： Ge Y,Deva DP,Connelly KA,Yan AT

更新日期：2020-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Prolonged sitting (sedentary behavior) has deleterious cardiovascular and metabolic correlates; however, little is known about the associations of too much sitting with all-cause and cardiovascular mortality risk. In addition to the adverse effects of total sitting time, the manner in which it is accu...

journal_title：Current opinion in cardiology

authors： Dunstan DW,Thorp AA,Healy GN

更新日期：2011-09-01 00:00:00

abstract：:With marked improvements in stent technology as adjunct to balloon angioplasty for multivessel coronary disease, several newer trials are currently in progress reviewing the optimal revascularization strategy. This review provides background from older studies and addresses the current progress and design of these new...

journal_title：Current opinion in cardiology

authors： Bakhai A,Stables RH,Prasad S,Sigwart U

更新日期：2000-11-01 00:00:00