Genetic risk stratification in cardiac arrhythmias.

Abstract:

PURPOSE OF REVIEW:The current article provides a concise summary of the possibilities and limitations of genotype-based risk stratification of cardiac arrhythmias. We will outline the most important findings of the recent years in the light of their chronological and conceptual development. RECENT FINDINGS:Genotype-phenotype association studies in families with single-gene disorders as well as in the general population led to the discovery of several DNA variants significantly associated with the risk of sudden death or life-threatening arrhythmias. In genetic (monogenic) diseases, the disease-causing mutations modulate the risk of events and response to antiarrhythmic therapy according to the specific gene involved, to their position of the mutation and to their functional effects. These causal relationships have been quite well characterized in the case of long QT syndrome but are still less defined in the case of other inherited conditions. Quantitatively, the risk associated with a single genetic variant is large for DNA variants that cause monogenic inherited arrhythmias. Much different is the case of more common variants associated with the risk of arrhythmias in the general population as they are generally associated with a small effect size. SUMMARY:Genetic profiling identifies arrhythmogenic risk even if a complete picture allowing high-granularity risk stratification is yet to come.

journal_name

Curr Opin Cardiol

authors

Napolitano C,Mazzanti A,Priori SG

doi

10.1097/HCO.0000000000000506

subject

Has Abstract

pub_date

2018-05-01 00:00:00

pages

298-303

issue

3

eissn

0268-4705

issn

1531-7080

journal_volume

33

pub_type

杂志文章,评审
  • Hypertrophic cardiomyopathy: do sudden death prevention strategies in children differ between Europe and North America?

    abstract:PURPOSE OF REVIEW:Hypertrophic cardiomyopathy (HCM) is the second most common childhood heart muscle disease and is the most common cause of unexpected sudden cardiac death in young people. The purpose of this review is to describe the risk of sudden death, to assess which of the criteria conventionally used as indicat...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0b013e32835dd020

    authors: Östman-Smith I,Rossano JW,Shaddy RE

    更新日期:2013-03-01 00:00:00

  • Mechanical circulatory support of the failing heart.

    abstract::Over the past 30 years, there have been significant pharmacological and technological advances in the treatment of cardiogenic shock. Although most patients who develop cardiogenic shock can be effectively treated with conventional therapy, including inotropic and vasodilating drugs and intra-aortic balloon pumps, a s...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/00001573-199403000-00013

    authors: Votapka TV,Pennington DG

    更新日期:1994-03-01 00:00:00

  • Antithrombotic drugs in cardiovascular medicine: a year in review.

    abstract:PURPOSE OF REVIEW:To provide an up to date review of the most recent randomized clinical trials in the field of antithrombotic drugs for cardiovascular diseases. RECENT FINDINGS:In 2017, low-dose anti-Xa treatment added to aspirin proved to be more efficacious than either treatment alone in patients with stable athero...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0000000000000530

    authors: Ibrahim H,Rondina M,Welt FGP

    更新日期:2018-07-01 00:00:00

  • Pediatric cardiac catheterization.

    abstract::The publications of 2000 and 2001 stress how interventional pediatric cardiology has moved from angioplasty to device placement. This review summarizes the important articles during the past year that evaluated the safety and efficacy of atrial septal defect devices, patent ductus occluders, and stents to treat coarct...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/00001573-200205000-00013

    authors: Rocchini AP

    更新日期:2002-05-01 00:00:00

  • Cardiac angiogenesis and gene therapy: a strategy for myocardial revascularization.

    abstract::Angiogenesis, the de novo formation of new vasculature, is a critical response to ischemia that provides neovascularization of ischemic tissues. In therapeutic angiogenesis, an angiogen--a mediator that induces angiogenesis--is delivered to targeted tissues, augmenting the native angiogenic process and enhancing reper...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/00001573-199911000-00012

    authors: Hamawy AH,Lee LY,Crystal RG,Rosengart TK

    更新日期:1999-11-01 00:00:00

  • Diagnostic testing of the emergency department patient with chest pain.

    abstract::In evaluating patients with nondiagnostic initial clinical or electrocardiogram (ECG) findings for acute cardiac ischemia, continuous 12-lead ECG monitoring increases the detection of diagnostic ECG findings, including ST-segment elevation, in patients awaiting hospital admission. Rest scanning with technitium-99m ses...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/00001573-199807000-00005

    authors: Zalenski RJ,Shamsa FH

    更新日期:1998-07-01 00:00:00

  • Recent advances in non-interventional pediatric cardiac catheterization.

    abstract:PURPOSE OF REVIEW:The role of cardiac catheterization in pediatric cardiology has changed significantly in the past 10-15 years. As interventional procedures dominate the field, it is important to examine the recent advances in non-interventional pediatric cardiac catheterization. RECENT FINDINGS:Meaningful and accura...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/01.hco.0000154067.99851.4a

    authors: Kanter JP,Hellenbrand WE

    更新日期:2005-03-01 00:00:00

  • Percutaneous coronary intervention strategies in patients with ST-segment elevation myocardial infarction and multivessel coronary artery disease.

    abstract:PURPOSE OF REVIEW:This review aims to summarize recent reports on percutaneous coronary intervention (PCI) strategies for patients with ST-elevation myocardial infarction (STEMI) and multivessel coronary artery disease (CAD). RECENT FINDINGS:Recent randomized clinical trials and meta-analyses have suggested that patie...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0000000000000446

    authors: Thomas MP,Bates ER

    更新日期:2017-11-01 00:00:00

  • Re-infarction after primary percutaneous coronary intervention.

    abstract:PURPOSE OF REVIEW:Thrombus formation, usually on a ruptured atherosclerotic plaque, is pivotal in the pathogenesis of ST segment elevation myocardial infarction (STEMI). This thrombus formation provides the milieu for re-occlusion of the infarct-related artery, the main location of re-infarction post-STEMI. Although ra...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0000000000000193

    authors: French JK,Burgess S,Chew DP

    更新日期:2015-07-01 00:00:00

  • Reverse ventricular remodeling: mechanical options.

    abstract:PURPOSE OF REVIEW:The aim of this review is to update the cardiovascular clinician on the current status of surgical therapies aimed at achieving reverse ventricular remodeling. RECENT FINDINGS:Relevant research focusing on mechanical options for reverse ventricular remodeling will be referenced and summarized. SUMMA...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/01.hco.0000221583.48748.d9

    authors: McGee EC,Gillinov AM,McCarthy PM

    更新日期:2006-05-01 00:00:00

  • Bridge or continue Coumadin for device surgery: a randomized controlled trial rationale and design.

    abstract:PURPOSE OF REVIEW:Many patients requiring cardiac arrhythmia device surgery are on chronic oral anticoagulation therapy. The periprocedural management of their anticoagulation presents a dilemma to physicians, particularly in the subset of patients with moderate-to-high risk of arterial thromboembolic events. Physician...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/hco.0b013e32831bef53

    authors: Birnie D,Healey JS,Krahn A,Essebag V,Sivakumaran S,Tang A,Simpson C

    更新日期:2009-01-01 00:00:00

  • Statins and kidney disease: is the study of heart and renal protection at the cutting edge of evidence?

    abstract:PURPOSE OF REVIEW:Dyslipidaemias are noted in all stages of chronic kidney disease (CKD). Currently most evidence for their treatment comes from secondary retrospective analyses of patient subgroups with CKD recruited into clinical trials powered of hypertensive and dyslipideamic cohorts powered for cardiovascular endp...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0b013e328353b988

    authors: Jenkins M,Goldsmith D

    更新日期:2012-07-01 00:00:00

  • Hybrid palliation in hypoplastic left heart syndrome.

    abstract:PURPOSE OF REVIEW:Despite progressive improvement in surgical results, hypoplastic left heart syndrome remains one of the congenital heart abnormalities with the greatest morbidity and mortality. Hybrid approaches to management, combining surgical and interventional catheterization procedures, have been introduced to m...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0b013e328014d945

    authors: Gutgesell HP,Lim DS

    更新日期:2007-03-01 00:00:00

  • A discussion of electrocardiographic screening and sudden cardiac death prevention: evidence and consensus.

    abstract:PURPOSE OF REVIEW:Frequent media reports of sudden cardiac arrest or death (SCA/SCD) keep alive a debate as to how best to prevent these tragedies. Several new studies in the past 2 years serve as an impetus to reframe the debate into a reasonable discussion that seeks to obtain more evidence wherever needed and to dev...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章

    doi:10.1097/HCO.0b013e32835dd0fe

    authors: Vetter VL,Dugan NP

    更新日期:2013-03-01 00:00:00

  • Coronary bypass surgery: from variability to standardization?

    abstract:PURPOSE OF REVIEW:The review summarizes recent literature on standardization of care in coronary artery bypass grafting (CABG), with particular attention to the impact of standardization on outcomes and resource utilization. RECENT FINDINGS:An increasing number of studies have demonstrated potential advantages to stan...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0000000000000113

    authors: Kilic A,Whitman GJ

    更新日期:2014-11-01 00:00:00

  • New strategies in myocardial preservation.

    abstract::Myocardial protection seems to be evolving toward simplified techniques, among which the use of minimally diluted tepid blood cardioplegia delivered retrograde or in a combined fashion is gaining wider clinical acceptance. In the future, agents that can duplicate the cardioprotective effects of ischemic preconditionin...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/00001573-199711000-00002

    authors: Menasché P

    更新日期:1997-11-01 00:00:00

  • Prosthetic valve selection in patients with left-sided endocarditis: bioprosthetic or mechanical valves?

    abstract:PURPOSE OF REVIEW:Studies comparing outcomes in left-sided endocarditis based on the prosthesis selected for implantation are limited and no randomized studies have been performed. The purpose of this review is to summarize the best available studies to determine what prosthesis is most appropriate when valve replaceme...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0000000000000040

    authors: Moon MR

    更新日期:2014-03-01 00:00:00

  • Endocarditis.

    abstract::Endocarditis remains a major worldwide problem despite significant advances in diagnostic and therapeutic interventions. This review centers on the recent studies that have been published in the past year concerning the epidemiologic, diagnostic, and therapeutic aspects of infective and noninfective endocarditis in bo...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/00001573-199703000-00006

    authors: Farmer JA,Torre G

    更新日期:1997-03-01 00:00:00

  • DiGeorge syndrome: an update.

    abstract:PURPOSE OF REVIEW:This article is an update on DiGeorge syndrome research focusing on the synergy of human and model systems genetics toward the understanding of conotruncal and aortic arch defects. RECENT FINDINGS:The identification of mutations of the human T-Box1 (TBX1) gene and progress on research of Tbx1 functio...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/00001573-200405000-00002

    authors: Baldini A

    更新日期:2004-05-01 00:00:00

  • Nutraceuticals and coronary heart disease.

    abstract:PURPOSE OF REVIEW:Although many reviews have focused on diet as a determinant of coronary heart disease (CHD), little is known about the use of specific nutrients or food products. The aim of this review was to examine the role of several functional foods, or nutraceuticals, in the prevention or treatment of CHD. RECE...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0b013e32836081a5

    authors: Garcia-Rios A,Delgado-Lista J,Alcala-Diaz JF,Lopez-Miranda J,Perez-Martinez P

    更新日期:2013-07-01 00:00:00

  • Current and novel biomarkers in heart failure: bench to bedside.

    abstract:PURPOSE OF REVIEW:Natriuretic peptides, high-sensitivity cardiac troponins, and suppression of tumorigenicity 2 are novel biomarkers that reflect the intricate pathophysiology of heart failure and can thus be used for the diagnosis, management, and prognosis of heart failure. RECENT FINDINGS:This review article descri...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0000000000000254

    authors: Ghashghaei R,Arbit B,Maisel AS

    更新日期:2016-03-01 00:00:00

  • Pediatric cardiac electrophysiology.

    abstract::Over the past year, many advances have been made in the management of cardiac arrhythmias in the pediatric patient. It has become evident that the new surgical procedures for congenital cardiac disease can result in arrhythmia-associated morbidity and mortality. New pharmacologic agents such as adenosine have been s...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/00001573-199102000-00016

    authors: Kaminer SJ,Gelband H

    更新日期:1991-02-01 00:00:00

  • The combination of obesity and hypertension: a highly unfavorable phenotype requiring attention.

    abstract:PURPOSE OF REVIEW:Body habitus is a key lifestyle characteristic whose current status and future projections are disconcerting. The percentage of the global population who are either overweight or obese has substantially increased, with no indication that any country has a solution to this issue. Hypertension is a key ...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0000000000000294

    authors: Arena R,Daugherty J,Bond S,Lavie CJ,Phillips S,Borghi-Silva A

    更新日期:2016-07-01 00:00:00

  • Vitamin D and cardiovascular disease risk: emerging evidence.

    abstract:PURPOSE OF REVIEW:Vitamin D deficiency is common throughout the world, with a particularly high prevalence in northern latitudes and colder climates. Although the best known sequelae of vitamin D deficiency involve the musculoskeletal system, a growing body of evidence suggests that vitamin D status may influence cardi...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0b013e32833cd491

    authors: Swales HH,Wang TJ

    更新日期:2010-09-01 00:00:00

  • New surgical therapies for heart failure.

    abstract::A growing number of patients present with heart failure. Some of them may qualify for surgical correction of their cardiac condition. Since heart transplantation will always be available to only a small number of patients, several new surgical techniques have been developed for approval in heart failure patients. Clas...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/00001573-200305000-00004

    authors: Loebe M,Soltero E,Thohan V,Lafuente JA,Noon GP

    更新日期:2003-05-01 00:00:00

  • Magnetic resonance for the assessment of myocardial viability.

    abstract:PURPOSE OF REVIEW:Cardiac magnetic resonance imaging has an expanding role as a preferred modality for the detection and characterization of myocardial viability. RECENT FINDINGS:Improving the accuracy of cardiac magnetic resonance for detecting viable myocardium has been one focus of investigators. In segments with i...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/01.hco.0000240584.68720.ae

    authors: Isbell DC,Kramer CM

    更新日期:2006-09-01 00:00:00

  • Preventive cardiology.

    abstract::Over the past year, significant new advances have been made in preventive cardiology. New trials of lipid lowering, estrogen therapy, and hypertension control have added to our understanding of the pathophysiology and prevention of coronary atherosclerosis. This review highlights these new trials and provides insight ...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/00001573-199909000-00006

    authors: Foody JA

    更新日期:1999-09-01 00:00:00

  • Comparative imaging techniques and models.

    abstract::The explosion of high-resolution imaging technology in recent years has led to the increasing problem of choosing imaging modalities appropriate to specific clinical questions. In terms of structural information, for example, the relative benefits of ultrasound versus magnetic resonance imaging versus computed tomogr...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/00001573-199212000-00015

    authors: Simpson IA,Sahn DJ

    更新日期:1992-12-01 00:00:00

  • How to avoid inappropriate therapy.

    abstract:PURPOSE OF REVIEW:With wider indications for implantable cardioverter defibrillator therapy, more patients at lower risk for ventricular tachyarrhythmia receive this treatment. To maintain the ratio of benefit versus side-effects at an acceptable level, the risk of inappropriate implantable cardioverter defibrillator t...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0b013e3282f30436

    authors: Israel CW

    更新日期:2008-01-01 00:00:00

  • Etiology of valvular heart disease.

    abstract::The incidence of congenital valvular heart disease has not significantly altered in recent decades. Major factors contributing to altered profiles of acquired valvular heart disease in the past few decades include an increased elderly segment of the population and increasing recognition of nonrheumatic forms of valvul...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/00001573-199603000-00002

    authors: Rose AG

    更新日期:1996-03-01 00:00:00