Current and novel biomarkers in heart failure: bench to bedside.

Abstract:

PURPOSE OF REVIEW:Natriuretic peptides, high-sensitivity cardiac troponins, and suppression of tumorigenicity 2 are novel biomarkers that reflect the intricate pathophysiology of heart failure and can thus be used for the diagnosis, management, and prognosis of heart failure. RECENT FINDINGS:This review article describes the significance of B-type natriuretic peptide (BNP), N-terminal prohormone of BNP, ST2, and cardiac troponins. We outline their new roles in guiding the management of heart failure as well as strong prognostic indicators for adverse cardiovascular outcomes. SUMMARY:By recognizing the diagnostic and prognostic significance of these biomarkers, clinicians can utilize these biomarkers to more accurately evaluate and risk stratify patients. These markers can also be used to help guide the medical management of heart failure. The best approach for an accurate diagnosis, management, and prognosis of heart failure will likely involve a multimarker panel of biomarkers, which may include high-sensitivity troponins, BNP, N-terminal prohormone of BNP, and ST2.

journal_name

Curr Opin Cardiol

authors

Ghashghaei R,Arbit B,Maisel AS

doi

10.1097/HCO.0000000000000254

subject

Has Abstract

pub_date

2016-03-01 00:00:00

pages

191-5

issue

2

eissn

0268-4705

issn

1531-7080

journal_volume

31

pub_type

杂志文章,评审
  • Trials comparing coronary artery bypass grafting with percutaneous transluminal coronary angioplasty and primary stent implantation in patients with multivessel coronary artery disease.

    abstract::With marked improvements in stent technology as adjunct to balloon angioplasty for multivessel coronary disease, several newer trials are currently in progress reviewing the optimal revascularization strategy. This review provides background from older studies and addresses the current progress and design of these new...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/00001573-200011000-00003

    authors: Bakhai A,Stables RH,Prasad S,Sigwart U

    更新日期:2000-11-01 00:00:00

  • The role of tricuspid valve repair and replacement in right heart failure.

    abstract:PURPOSE OF REVIEW:The presence of tricuspid regurgitation in the setting of right ventricular dysfunction is associated with poor prognosis. The purpose of this review is to describe the pathophysiology of functional tricuspid regurgitation, summarize the current reports favoring a more aggressive approach toward tricu...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0b013e3283512051

    authors: Pinney SP

    更新日期:2012-05-01 00:00:00

  • New strategies in myocardial preservation.

    abstract::Myocardial protection seems to be evolving toward simplified techniques, among which the use of minimally diluted tepid blood cardioplegia delivered retrograde or in a combined fashion is gaining wider clinical acceptance. In the future, agents that can duplicate the cardioprotective effects of ischemic preconditionin...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/00001573-199711000-00002

    authors: Menasché P

    更新日期:1997-11-01 00:00:00

  • Management of combined carotid and coronary artery disease.

    abstract::Although it has been the topic of intense medical and surgical attention for over 20 years, the coexistence of severe carotid artery disease in patients undergoing coronary artery bypass graft continues to be a major cause of perioperative morbidity and mortality. Refinements in diagnostic modalities, mainly by duplex...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/00001573-199609000-00012

    authors: Schepens MA,Vermeulen FE

    更新日期:1996-09-01 00:00:00

  • Long-lasting benefits of exercise for those living with a Fontan circulation.

    abstract:PURPOSE OF REVIEW:In recent decades, the physiology and late outcomes of the Fontan circulation have become better characterized and interest has turned to interventions that might improve exercise capacity and clinical sequelae. No therapy has currently been shown to be more effective for improving exercise capacity i...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0000000000000582

    authors: Cordina R,d'Udekem Y

    更新日期:2019-01-01 00:00:00

  • Physical activity and fitness for the prevention of hypertension.

    abstract:PURPOSE OF REVIEW:The aim of this review is to evaluate the most recent literature about the role of physical activity, exercise, and fitness in hypertension prevention. RECENT FINDINGS:Strong evidence indicates that performing moderate-to-vigorous physical activity, particularly aerobic exercise, and improving cardio...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0000000000000526

    authors: Bakker EA,Sui X,Brellenthin AG,Lee DC

    更新日期:2018-07-01 00:00:00

  • Incidence, definition, diagnosis, and management of the cardiac resynchronization therapy nonresponder.

    abstract:PURPOSE OF REVIEW:Cardiac resynchronization therapy (CRT) reduces morbidity and mortality in patients with mild-to-severe heart failure. However, up to 40% of CRT recipients are nonresponders. This review addresses important aspects with regard to the identification and management of CRT nonresponders. RECENT FINDINGS...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/HCO.0000000000000140

    authors: Zhang Q,Zhou Y,Yu CM

    更新日期:2015-01-01 00:00:00

  • Dronedarone: a novel antiarrhythmic agent for the treatment of atrial fibrillation.

    abstract:PURPOSE OF REVIEW:To describe the electrophysiological profile and the clinical portfolio of dronedarone, a new multichannel-blocking antiarrhythmic drug developed for the treatment of atrial fibrillation. RECENT FINDINGS:Dronedarone is a derivative of amiodarone that is free of iodine and less lipophilic. The drug ha...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0b013e32833354e4

    authors: Duray GZ,Ehrlich JR,Hohnloser SH

    更新日期:2010-01-01 00:00:00

  • Emerging clinical roles for ambulatory blood pressure monitoring.

    abstract::Ambulatory blood pressure monitoring is becoming increasingly popular in the diagnosis and treatment of patients with hypertensive disorders. Widespread clinical use, however, has been limited by a lack of normative data and prospective, controlled clinical studies of its impact on subsequent cardiovascular morbidity ...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/00001573-199309000-00007

    authors: Canzanello VJ,Sheps SG

    更新日期:1993-09-01 00:00:00

  • Congenital heart surgery.

    abstract::In reviewing selected publications on congenital heart disease management for 1990 and 1991, some topics have been chosen for discussion, including isolated patent ductus arteriosus, coarctation of the aorta, critical aortic stenosis in early infancy, hypoplastic left-heart syndrome, pulmonary artery banding, Fontan p...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/00001573-199204000-00010

    authors: Mee RB

    更新日期:1992-04-01 00:00:00

  • Stress echocardiography versus myocardial SPECT for risk stratification of patients with coronary artery disease.

    abstract:PURPOSE OF REVIEW:Diagnostic testing using noninvasive imaging has become an integral part of risk stratification in patients with coronary artery disease. It is important to understand the integral strengths and weaknesses between the different modalities of stress testing and to apply accurately the type of test the ...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/00001573-200311000-00010

    authors: Maganti K,Rigolin VH

    更新日期:2003-11-01 00:00:00

  • Noninvasive imaging of myocardial extracellular matrix for assessment of fibrosis.

    abstract:PURPOSE OF REVIEW:Myocardial fibrosis is a common feature of many cardiomyopathies, including hypertrophic cardiomyopathy. Myocardial fibrosis has been shown to be reversible and treatable with timely intervention. Although early detection and assessment of fibrosis is crucial, adequate diagnostics are still in develop...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0b013e32835f5a2b

    authors: Won S,Davies-Venn C,Liu S,Bluemke DA

    更新日期:2013-05-01 00:00:00

  • Thrombolytic therapy in acute pulmonary embolism.

    abstract:PURPOSE OF REVIEW:The goal of this review is to offer an overview of the use of thrombolytic therapy in acute pulmonary embolism. Clinicians including internists, surgeons, pulmonologists, and other specialists continue to face decisions regarding massive and submassive acute pulmonary embolism in their daily routines....

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0b013e328358308c

    authors: Tapson VF

    更新日期:2012-11-01 00:00:00

  • Mitral clip - looking back and moving forward.

    abstract:PURPOSE OF REVIEW:Guidelines indicate surgical intervention for patients with symptomatic severe mitral regurgitation or signs of left ventricular dilatation or dysfunction. However, many patients do not receive surgery because of age or comorbidities, and have poor outcomes with conservative therapy. Transcatheter mit...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0000000000000261

    authors: Fam NP,Ross HJ,Verma S

    更新日期:2016-03-01 00:00:00

  • Adenosine single photon emission computed tomography for assessing risk after myocardial infarction: recent developments.

    abstract:PURPOSE OF REVIEW:While the prognostic power of adenosine single photon emission computed tomography myocardial perfusion imaging has been validated in multiple patient populations including those with known or suspected coronary artery disease, the utility of this modality in assessing risk after an acute myocardial i...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0b013e32820652c9

    authors: Dorfman TA,Iskandrian AE

    更新日期:2007-09-01 00:00:00

  • An update in the management of acute decompensated heart failure.

    abstract:PURPOSE OF REVIEW:This review will provide an overview of recent advances in the management of acute decompensated heart failure, focusing on major publications from the past few years. RECENT FINDINGS:There have been several publications investigating different strategies in the management of acute decompensated hear...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0000000000000038

    authors: Maze R,Haddad H

    更新日期:2014-03-01 00:00:00

  • Recent trends in infective endocarditis: influence of case definitions.

    abstract:PURPOSE OF REVIEW:Infective endocarditis continues to pose major challenges in diagnosis and management despite advances in understanding the epidemiology, microbiology, and pathology of the disease. The purpose of this article is to provide a review of diagnosis, microbiology, and treatment of infective endocarditis, ...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/00001573-200403000-00012

    authors: Devlin RK,Andrews MM,von Reyn CF

    更新日期:2004-03-01 00:00:00

  • Molecular aspects of myocarditis.

    abstract::The mechanisms of pathogenesis of myocarditis have remained elusive. Despite the demonstration a decade ago that persistent viral infection of the myocardium occurred in many patients, a clear description of the pathologic progression has not been forthcoming. Over the past year, a number of studies have added to the ...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:

    authors: Bowles NE,Towbin JA

    更新日期:1998-05-01 00:00:00

  • Nutraceuticals and coronary heart disease.

    abstract:PURPOSE OF REVIEW:Although many reviews have focused on diet as a determinant of coronary heart disease (CHD), little is known about the use of specific nutrients or food products. The aim of this review was to examine the role of several functional foods, or nutraceuticals, in the prevention or treatment of CHD. RECE...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0b013e32836081a5

    authors: Garcia-Rios A,Delgado-Lista J,Alcala-Diaz JF,Lopez-Miranda J,Perez-Martinez P

    更新日期:2013-07-01 00:00:00

  • New advances in antirejection therapy.

    abstract:PURPOSE OF REVIEW:The prevention and treatment of rejection have been the major focus of clinical and research studies since the inception of heart transplantation. Recent improvement in survival after transplant has been in large part due to continued advancement in antirejection therapies. RECENT FINDINGS:The combin...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0b013e32802bf772

    authors: Chan M,Pearson GJ

    更新日期:2007-03-01 00:00:00

  • Statins and kidney disease: is the study of heart and renal protection at the cutting edge of evidence?

    abstract:PURPOSE OF REVIEW:Dyslipidaemias are noted in all stages of chronic kidney disease (CKD). Currently most evidence for their treatment comes from secondary retrospective analyses of patient subgroups with CKD recruited into clinical trials powered of hypertensive and dyslipideamic cohorts powered for cardiovascular endp...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0b013e328353b988

    authors: Jenkins M,Goldsmith D

    更新日期:2012-07-01 00:00:00

  • Which prosthetic valve should we choose?

    abstract::In this review I concentrate on issues related to prosthetic valves themselves: their development, performance, and durability. For example, mechanical failure or tissue deterioration appear to be intrinsic properties of the valve and are therefore central to my topic, whereas the development, diagnosis, and managemen...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/00001573-199503000-00008

    authors: Treasure T

    更新日期:1995-03-01 00:00:00

  • Statins for primary prevention of cardiovascular disease: the benefits outweigh the risks.

    abstract:PURPOSE OF REVIEW:Statins significantly reduce cardiovascular morbidity and mortality in patients with and without coronary heart disease. Recently, much debate has focused on use of statins for primary prevention following a class-wide safety label change by the US Food and Drug Administration amidst concerns of worse...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0b013e32836429e6

    authors: Minder CM,Blumenthal RS,Blaha MJ

    更新日期:2013-09-01 00:00:00

  • The combination of obesity and hypertension: a highly unfavorable phenotype requiring attention.

    abstract:PURPOSE OF REVIEW:Body habitus is a key lifestyle characteristic whose current status and future projections are disconcerting. The percentage of the global population who are either overweight or obese has substantially increased, with no indication that any country has a solution to this issue. Hypertension is a key ...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0000000000000294

    authors: Arena R,Daugherty J,Bond S,Lavie CJ,Phillips S,Borghi-Silva A

    更新日期:2016-07-01 00:00:00

  • Trials of cardiovascular risk factor management in type 2 diabetes.

    abstract:PURPOSE OF REVIEW:To provide an overview of recent clinical trial findings relevant to cardiovascular risk management in patients with diabetes. RECENT FINDINGS:Recent trial evidence has demonstrated benefits of routine blood pressure (BP) lowering, regardless of initial BP levels, in people with type 2 diabetes. In a...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0b013e32832a7b01

    authors: Patel A,Joshi R,de Galan B

    更新日期:2009-07-01 00:00:00

  • Genetic basis of atrial fibrillation.

    abstract:PURPOSE OF REVIEW:Atrial fibrillation, the most common cardiac supraventricular arrhythmia, affects more than 5 million people worldwide. Increasing evidence has demonstrated that genetic factors play an important role in the pathogenesis of atrial fibrillation, and multiple genes responsible for atrial fibrillation ha...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0000000000000051

    authors: Hong K,Xiong Q

    更新日期:2014-05-01 00:00:00

  • The intrinsic cardiac nervous system and atrial fibrillation.

    abstract:PURPOSE OF REVIEW:Radiofrequency ablation techniques to cure cardiac arrhythmias have focused on destroying myocardial tissue involved in abnormal excitation or conduction. This review will address recent basic and clinical studies which suggest that targeting autonomic nerves and ganglia on the large vessels and the h...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/01.hco.0000198980.40390.e4

    authors: Scherlag BJ,Po S

    更新日期:2006-01-01 00:00:00

  • Will left-ventricular assist device therapy replace heart transplantation in the foreseeable future?

    abstract:PURPOSE OF REVIEW:Implantation of circulatory assist devices as a permanent alternative to heart transplantation, so-called Destination Therapy, has become a promising new option for treatment of patients with advanced heart failure who are not candidates for heart transplantation. RECENT FINDINGS:The landmark REMATCH...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/01.hco.0000153949.42189.03

    authors: Lietz K,Miller LW

    更新日期:2005-03-01 00:00:00

  • How to avoid inappropriate therapy.

    abstract:PURPOSE OF REVIEW:With wider indications for implantable cardioverter defibrillator therapy, more patients at lower risk for ventricular tachyarrhythmia receive this treatment. To maintain the ratio of benefit versus side-effects at an acceptable level, the risk of inappropriate implantable cardioverter defibrillator t...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0b013e3282f30436

    authors: Israel CW

    更新日期:2008-01-01 00:00:00

  • Five decades of pediatric heart transplantation: challenges overcome, challenges remaining.

    abstract:PURPOSE OF REVIEW:Pediatric heart transplants continue to be the therapy of choice for children with end stage heart failure. The interplay of limited donor supply, improvement in ventricular assist device (VAD) technology and utilization, and a focus on optimizing long-term outcomes make it critically important for pr...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0000000000000351

    authors: Zangwill S

    更新日期:2017-01-01 00:00:00