Adenosine single photon emission computed tomography for assessing risk after myocardial infarction: recent developments.

Abstract:

PURPOSE OF REVIEW:While the prognostic power of adenosine single photon emission computed tomography myocardial perfusion imaging has been validated in multiple patient populations including those with known or suspected coronary artery disease, the utility of this modality in assessing risk after an acute myocardial infarction in the primary angioplasty era is still a topic of debate. RECENT FINDINGS:The INSPIRE trial showed that early adenosine single photon emission computed tomography myocardial perfusion imaging is capable of identifying low-risk patients for early hospital discharge after acute myocardial infarction. This novel study demonstrated that intensive medical therapy is a reasonable strategy in low, intermediate, and high-risk post-myocardial infarction patients with preserved left ventricular function. SUMMARY:The INSPIRE trial established the role for early adenosine single photon emission computed tomography myocardial perfusion imaging as a tool for risk stratification in stable patients after an acute myocardial infarction and provided evidence that intensive medical therapy is comparable to coronary revascularization in suppressing ischemia and presumably improving cardiac outcomes. It remains to be seen whether these new findings will alter current American College of Cardiology/American Heart Association guidelines, which emphasize a primary role of coronary revascularization in acute coronary syndromes.

journal_name

Curr Opin Cardiol

authors

Dorfman TA,Iskandrian AE

doi

10.1097/HCO.0b013e32820652c9

subject

Has Abstract

pub_date

2007-09-01 00:00:00

pages

401-7

issue

5

eissn

0268-4705

issn

1531-7080

pii

00001573-200709000-00002

journal_volume

22

pub_type

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