Abstract:
PURPOSE OF REVIEW:To compare the potential of high-density lipoprotein (HDL) cholesterol and apolipoprotein (apo) A-I, the major protein in HDL particles, in predicting cardiovascular risk. Pros and cons for using these risk markers are discussed. RECENT FINDINGS:Both HDL cholesterol and apoA-I are in most clinical conditions antiatherogenic - the higher the values, the lower the cardiovascular risk. Methodological and physiological factors speak in favour of using apoA-I rather than HDL cholesterol as a marker of risk. In prospective risk studies and in lipid-lowering trials it has been shown that the apoB/A-I ratio, which reflects the cholesterol balance between all potentially atherogenic (apoB) and antiatherogenic lipoproteins (apoA-I), is a better risk marker than low-density lipoprotein cholesterol, HDL cholesterol and lipid ratios in predicting cardiovascular risk and response to lipid lowering induced by statins. Practical advantages speak in favour of using apoB and apoA-I - fasting is not needed to analyze and interpret the values of apoB and apoA-I. SUMMARY:New guidelines should be developed in which target values for apoB and apoA-I are defined to enable the use of these new strong risk markers/factors in clinical practice.
journal_name
Curr Opin Cardioljournal_title
Current opinion in cardiologyauthors
Walldius G,Jungner Idoi
10.1097/HCO.0b013e3281bd8849subject
Has Abstractpub_date
2007-07-01 00:00:00pages
359-67issue
4eissn
0268-4705issn
1531-7080pii
00001573-200707000-00016journal_volume
22pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:Myocardial fibrosis is a common feature of many cardiomyopathies, including hypertrophic cardiomyopathy. Myocardial fibrosis has been shown to be reversible and treatable with timely intervention. Although early detection and assessment of fibrosis is crucial, adequate diagnostics are still in develop...
journal_title:Current opinion in cardiology
pub_type: 杂志文章,评审
doi:10.1097/HCO.0b013e32835f5a2b
更新日期:2013-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Troponins are a cornerstone for the diagnosis of myocardial infarction, assessment of risk and prognosis, and determination of antithrombotic and a revascularization strategy in patients with acute coronary syndromes. Newer assays with higher precision for detection of troponin levels are about to ent...
journal_title:Current opinion in cardiology
pub_type: 杂志文章,评审
doi:10.1097/HCO.0b013e3283050808
更新日期:2008-07-01 00:00:00
abstract:PURPOSE OF REVIEW:This article is an update on DiGeorge syndrome research focusing on the synergy of human and model systems genetics toward the understanding of conotruncal and aortic arch defects. RECENT FINDINGS:The identification of mutations of the human T-Box1 (TBX1) gene and progress on research of Tbx1 functio...
journal_title:Current opinion in cardiology
pub_type: 杂志文章,评审
doi:10.1097/00001573-200405000-00002
更新日期:2004-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Bleeding has recently been identified as a major adverse outcome in patients with acute coronary syndromes. In this review, the importance of the association of bleeding with mortality and strategies to reduce bleeding with percutaneous coronary intervention are discussed. RECENT FINDINGS:Nine trials...
journal_title:Current opinion in cardiology
pub_type: 杂志文章,评审
doi:10.1097/HCO.0b013e32832d1ea2
更新日期:2009-07-01 00:00:00
abstract:PURPOSE OF REVIEW:The aim of this review is to evaluate the most recent literature about the role of physical activity, exercise, and fitness in hypertension prevention. RECENT FINDINGS:Strong evidence indicates that performing moderate-to-vigorous physical activity, particularly aerobic exercise, and improving cardio...
journal_title:Current opinion in cardiology
pub_type: 杂志文章,评审
doi:10.1097/HCO.0000000000000526
更新日期:2018-07-01 00:00:00
abstract:PURPOSE OF REVIEW:It has been more than 4 decades since the development of Fontan operation. With the contemporary surgical strategies to treat the patients with a single ventricle physiology, the medium-term survival of the patients following Fontan operation is excellent. Nonetheless, the Fontan circulation with a pu...
journal_title:Current opinion in cardiology
pub_type: 杂志文章,评审
doi:10.1097/HCO.0000000000000603
更新日期:2019-03-01 00:00:00
abstract::The mechanisms of pathogenesis of myocarditis have remained elusive. Despite the demonstration a decade ago that persistent viral infection of the myocardium occurred in many patients, a clear description of the pathologic progression has not been forthcoming. Over the past year, a number of studies have added to the ...
journal_title:Current opinion in cardiology
pub_type: 杂志文章,评审
doi:
更新日期:1998-05-01 00:00:00
abstract::The incidence of congenital valvular heart disease has not significantly altered in recent decades. Major factors contributing to altered profiles of acquired valvular heart disease in the past few decades include an increased elderly segment of the population and increasing recognition of nonrheumatic forms of valvul...
journal_title:Current opinion in cardiology
pub_type: 杂志文章,评审
doi:10.1097/00001573-199603000-00002
更新日期:1996-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Viability assessment has a key role in the management of patients with ischemic heart disease. Positron emission tomography (PET) is a unique modality that evaluates myocardial viability via assessing the tissues metabolic and perfusion properties. The mainstay of metabolic imaging relies on glucose m...
journal_title:Current opinion in cardiology
pub_type: 杂志文章,评审
doi:10.1097/HCO.0000000000000652
更新日期:2019-09-01 00:00:00
abstract::Coronary artery bypass surgery performed in patients with coronary artery disease and left ventricular dysfunction improves survival compared with antianginal therapy alone. The mechanisms for this survival advantage with revascularization therapy have not been systematically elucidated. Many of these patients have "h...
journal_title:Current opinion in cardiology
pub_type: 杂志文章,评审
doi:10.1097/00001573-199607000-00008
更新日期:1996-07-01 00:00:00
abstract:PURPOSE OF REVIEW:A recently published study has alerted the cardiovascular community to the existence of a significant and previously unrecognized risk of subclinical valve thrombosis following implantation of surgical and catheter-based bioprosthetic valves. The purpose of this article is to review our current unders...
journal_title:Current opinion in cardiology
pub_type: 杂志文章,评审
doi:10.1097/HCO.0000000000000373
更新日期:2017-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Venous thromboembolism, including deep vein thrombosis and pulmonary embolism, represents a significant source of morbidity and mortality in the United States and worldwide. Most acutely ill medical patients are at risk for venous thromboembolism, and prophylaxis is recommended. However, acutely ill m...
journal_title:Current opinion in cardiology
pub_type: 杂志文章,评审
doi:10.1097/01.hco.0000141266.88385.67
更新日期:2004-11-01 00:00:00
abstract::Cardiovascular disease is the leading cause of death world-wide in populations older than 65 years of age. The variation in cardiovascular mortality rates in this population indicates a substantial potential for effective coronary prevention. The highest risk for development of coronary heart disease is in individuals...
journal_title:Current opinion in cardiology
pub_type: 杂志文章,评审
doi:10.1097/00001573-199703000-00017
更新日期:1997-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Despite its continued increase in prevalence in minorities, data regarding hypertension (HTN) control among such ethnic groups remains limited. This review highlights the most recent literature on the epidemiology, prevalence, and treatment strategies of HTN among four racial groups (non-Hispanic Whit...
journal_title:Current opinion in cardiology
pub_type: 杂志文章,评审
doi:10.1097/HCO.0000000000000293
更新日期:2016-07-01 00:00:00
abstract::Brugada syndrome is characterized by ST segment elevation in the right precordial leads, V1-V3 (unrelated to ischemia or structural disease), normal QT intervals, apparent right bundle branch block, and sudden cardiac death, particularly in men of Asian origin. An autosomal dominant mode of inheritance with variable e...
journal_title:Current opinion in cardiology
pub_type: 杂志文章,评审
doi:10.1097/00001573-199905000-00013
更新日期:1999-05-01 00:00:00
abstract::The introduction of new drugs, and a re-evaluation of older drugs, have radically changed the pharmacological management of heart failure. Angiotensin converting enzyme (ACE) inhibitors, digitalis, diuretics and the combination of nitrates and hydralazine are now used. The first Cooperative North Scandinavian Enalapri...
journal_title:Current opinion in cardiology
pub_type: 杂志文章,评审
doi:10.1097/00001573-199407000-00005
更新日期:1994-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Device therapy for atrial fibrillation remains contentious despite the recognized benefit of atrial pacing in sinus node dysfunction. There are various new specialized pacing algorithms that aim to provide rhythm or rate control in atrial fibrillation. We review the various options for device therapy ...
journal_title:Current opinion in cardiology
pub_type: 杂志文章,评审
doi:10.1097/01.hco.0000210302.56736.60
更新日期:2006-03-01 00:00:00
abstract::Patients with hypertrophic cardiomyopathy are at increased risk for sudden death. Recent studies have improved our ability to risk-stratify such patients and have elucidated several potential mechanisms of sudden death and syncope. Certain noninvasive tests, such as signal-averaged electrocardiography and measurements...
journal_title:Current opinion in cardiology
pub_type: 杂志文章,评审
doi:10.1097/00001573-199501000-00003
更新日期:1995-01-01 00:00:00
abstract:PURPOSE OF REVIEW:The appropriate treatment of patients with acute pulmonary embolism who present with right ventricular dysfunction but normal arterial blood pressure, and particularly the potential benefits of thrombolytic treatment in this setting, continue to be highly controversial. In the past year, several well ...
journal_title:Current opinion in cardiology
pub_type: 杂志文章,meta分析,评审
doi:10.1097/01.hco.0000179818.65329.bb
更新日期:2005-11-01 00:00:00
abstract:PURPOSE OF REVIEW:To provide an up to date review of the most recent randomized clinical trials in the field of antithrombotic drugs for cardiovascular diseases. RECENT FINDINGS:In 2017, low-dose anti-Xa treatment added to aspirin proved to be more efficacious than either treatment alone in patients with stable athero...
journal_title:Current opinion in cardiology
pub_type: 杂志文章,评审
doi:10.1097/HCO.0000000000000530
更新日期:2018-07-01 00:00:00
abstract:PURPOSE OF REVIEW:To evaluate whether long-term antiplatelet therapy may be effective and well tolerated. RECENT FINDINGS:Five important studies assessed the efficacy and safety of clopidogrel therapy in different settings. However, the problems concerning the duration of therapy are based substantially on the Clopido...
journal_title:Current opinion in cardiology
pub_type: 杂志文章,评审
doi:10.1097/01.hco.0000409964.20588.8c
更新日期:2011-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Cardiovascular disease (CVD) is the leading cause of morbidity and premature mortality in Europe and the United States, and is increasingly common in developing countries. High-density lipoprotein cholesterol (HDL-C) is an independent risk factor for CVD and is superior to low-density lipoprotein chol...
journal_title:Current opinion in cardiology
pub_type: 杂志文章,评审
doi:10.1097/HCO.0b013e328362210d
更新日期:2013-07-01 00:00:00
abstract::Magnetic resonance imaging of the cardiovascular system is now a well-recognized primary investigative technique for many conditions of structural abnormality in clinical cardiology, but the assessment of functional abnormality is also valuable and is increasingly being recognized by clinicians because of the accuracy...
journal_title:Current opinion in cardiology
pub_type: 杂志文章,评审
doi:10.1097/00001573-199611000-00013
更新日期:1996-11-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of the review is to provide an update on the safety and efficacy of catheter cryoablation. RECENT FINDINGS:Catheter cryoablation is a safe and clinically effective method for ablation of atrioventricular nodal reentrant supraventricular tachycardia. Although the acute procedural success r...
journal_title:Current opinion in cardiology
pub_type: 杂志文章,评审
doi:
更新日期:2005-01-01 00:00:00
abstract:PURPOSE OF REVIEW:To provide an update of the literature describing the link between lipoprotein a and vascular disease. RECENT FINDINGS:There is evidence that elevated plasma lipoprotein a levels are associated with coronary heart disease, stroke and other manifestations of atherosclerosis. Several mechanisms may be ...
journal_title:Current opinion in cardiology
pub_type: 杂志文章,评审
doi:10.1097/HCO.0b013e32832ac21a
更新日期:2009-07-01 00:00:00
abstract::In this paper, we review literature from June 1990 through May 1991. We discuss normal anatomy and physiology of the proximal coronary arteries, anomalous origin of the coronary arteries from an inappropriate aortic sinus, and anomalous origin of the left coronary artery from the pulmonary artery. Other topics revie...
journal_title:Current opinion in cardiology
pub_type: 杂志文章,评审
doi:10.1097/00001573-199112000-00011
更新日期:1991-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Many patients requiring cardiac arrhythmia device surgery are on chronic oral anticoagulation therapy. The periprocedural management of their anticoagulation presents a dilemma to physicians, particularly in the subset of patients with moderate-to-high risk of arterial thromboembolic events. Physician...
journal_title:Current opinion in cardiology
pub_type: 杂志文章,评审
doi:10.1097/hco.0b013e32831bef53
更新日期:2009-01-01 00:00:00
abstract:PURPOSE OF REVIEW:This review aims to summarize recent reports on percutaneous coronary intervention (PCI) strategies for patients with ST-elevation myocardial infarction (STEMI) and multivessel coronary artery disease (CAD). RECENT FINDINGS:Recent randomized clinical trials and meta-analyses have suggested that patie...
journal_title:Current opinion in cardiology
pub_type: 杂志文章,评审
doi:10.1097/HCO.0000000000000446
更新日期:2017-11-01 00:00:00
abstract::Catheter ablation techniques using radiofrequency current have become an accepted form of treatment for a variety of supraventricular tachycardias. The results are excellent in patients with preexcitation syndromes and as the complication rate is low, catheter ablation has become the first line of treatment for these ...
journal_title:Current opinion in cardiology
pub_type: 杂志文章,评审
doi:10.1097/00001573-199401000-00006
更新日期:1994-01-01 00:00:00
abstract:PURPOSE OF REVIEW:As the number of people living with heart failure continues to grow, future treatments will focus on efficient donor organ donation and ensuring safe and durable outcomes. This review will focus on organ procurement, graft surveillance and emerging therapies. RECENT FINDINGS:Preliminary studies into ...
journal_title:Current opinion in cardiology
pub_type: 杂志文章
doi:10.1097/HCO.0000000000000392
更新日期:2017-05-01 00:00:00