Apolipoprotein A-I versus HDL cholesterol in the prediction of risk for myocardial infarction and stroke.

Abstract:

PURPOSE OF REVIEW:To compare the potential of high-density lipoprotein (HDL) cholesterol and apolipoprotein (apo) A-I, the major protein in HDL particles, in predicting cardiovascular risk. Pros and cons for using these risk markers are discussed. RECENT FINDINGS:Both HDL cholesterol and apoA-I are in most clinical conditions antiatherogenic - the higher the values, the lower the cardiovascular risk. Methodological and physiological factors speak in favour of using apoA-I rather than HDL cholesterol as a marker of risk. In prospective risk studies and in lipid-lowering trials it has been shown that the apoB/A-I ratio, which reflects the cholesterol balance between all potentially atherogenic (apoB) and antiatherogenic lipoproteins (apoA-I), is a better risk marker than low-density lipoprotein cholesterol, HDL cholesterol and lipid ratios in predicting cardiovascular risk and response to lipid lowering induced by statins. Practical advantages speak in favour of using apoB and apoA-I - fasting is not needed to analyze and interpret the values of apoB and apoA-I. SUMMARY:New guidelines should be developed in which target values for apoB and apoA-I are defined to enable the use of these new strong risk markers/factors in clinical practice.

journal_name

Curr Opin Cardiol

authors

Walldius G,Jungner I

doi

10.1097/HCO.0b013e3281bd8849

subject

Has Abstract

pub_date

2007-07-01 00:00:00

pages

359-67

issue

4

eissn

0268-4705

issn

1531-7080

pii

00001573-200707000-00016

journal_volume

22

pub_type

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