Assessment of myocardial viability by PET.

Abstract:

PURPOSE OF REVIEW:Viability assessment has a key role in the management of patients with ischemic heart disease. Positron emission tomography (PET) is a unique modality that evaluates myocardial viability via assessing the tissues metabolic and perfusion properties. The mainstay of metabolic imaging relies on glucose metabolism using fluorodeoxyglucose, a radiolabeled glucose analog. Mismatch in perfusion metabolism data denotes hibernating myocardium with a high likelihood of functional recovery following revascularization. Matched absence or reduction in perfusion metabolism data represents scar with a low likelihood of functional recovery following revascularization. This review will focus on PET radiotracers and techniques used to assess myocardial viability. RECENT FINDINGS:Single-center studies have shown that patients with PET mismatch undergoing bypass grafting had improved survival compared with those on medical therapy. In addition to survival benefit, the patients who underwent PET-guided revascularization had significant improvement in angina and heart failure symptomology. Recent technological advancements in the field of PET-magnetic resonance (MR) opens a new frontier in the field of advanced imaging as it combines anatomical, functional, tissue characterization, and metabolic perfusion data obtained in one setting. The incremental value of PET/MRI is best established in diagnosing and monitoring disease activity in patients with cardiac sarcoidosis and occult malignancies, but more studies are needed to assess it value in viability assessment. SUMMARY:In conclusion, imaging myocardial viability by PET provides assessment of both physiological perfusion and myocardial tissue's metabolic activity to differentiate hibernating from scarred myocardium.

journal_name

Curr Opin Cardiol

authors

Khalaf S,Chamsi-Pasha M,Al-Mallah MH

doi

10.1097/HCO.0000000000000652

subject

Has Abstract

pub_date

2019-09-01 00:00:00

pages

466-472

issue

5

eissn

0268-4705

issn

1531-7080

pii

00001573-201909000-00003

journal_volume

34

pub_type

杂志文章,评审
  • Trials of cardiovascular risk factor management in type 2 diabetes.

    abstract:PURPOSE OF REVIEW:To provide an overview of recent clinical trial findings relevant to cardiovascular risk management in patients with diabetes. RECENT FINDINGS:Recent trial evidence has demonstrated benefits of routine blood pressure (BP) lowering, regardless of initial BP levels, in people with type 2 diabetes. In a...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0b013e32832a7b01

    authors: Patel A,Joshi R,de Galan B

    更新日期:2009-07-01 00:00:00

  • Stress testing for the evaluation of patients with mitral regurgitation.

    abstract:PURPOSE OF REVIEW:The emerging role of stress and particularly exercise echocardiography in mitral regurgitation has been recently emphasized. In fact, the evaluation of mitral regurgitation only under resting conditions might underestimate the full impact of the lesion and its clinical effects. RECENT FINDINGS:Exerci...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0b013e3283565c3b

    authors: Lancellotti P,Magne J

    更新日期:2012-09-01 00:00:00

  • Vagal stimulation for heart failure.

    abstract:PURPOSE OF REVIEW:On the very solid background of experimental and clinical studies pointing to the cardiovascular risks associated with depressed vagal reflexes and supported by specific experiments in animal models of heart failure, we are witnessing a rapidly growing interest in the very untraditional approach to th...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0b013e3283413961

    authors: Schwartz PJ

    更新日期:2011-01-01 00:00:00

  • Five decades of pediatric heart transplantation: challenges overcome, challenges remaining.

    abstract:PURPOSE OF REVIEW:Pediatric heart transplants continue to be the therapy of choice for children with end stage heart failure. The interplay of limited donor supply, improvement in ventricular assist device (VAD) technology and utilization, and a focus on optimizing long-term outcomes make it critically important for pr...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0000000000000351

    authors: Zangwill S

    更新日期:2017-01-01 00:00:00

  • The role of coronary revascularization in the management of heart failure: identification of candidates and review of results.

    abstract::As a result of the increasing size of waiting lists and lengthening of waiting times for heart transplantation, coronary revascularization has emerged as an important therapeutic option in the management of patients with ischemic cardiomyopathy. A critical challenge is the identification of candidates with regions of ...

    journal_title:Current opinion in cardiology

    pub_type: 临床试验,杂志文章,评审

    doi:10.1097/00001573-199605000-00008

    authors: Blitz A,Laks H

    更新日期:1996-05-01 00:00:00

  • Hybrid palliation in hypoplastic left heart syndrome.

    abstract:PURPOSE OF REVIEW:Despite progressive improvement in surgical results, hypoplastic left heart syndrome remains one of the congenital heart abnormalities with the greatest morbidity and mortality. Hybrid approaches to management, combining surgical and interventional catheterization procedures, have been introduced to m...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0b013e328014d945

    authors: Gutgesell HP,Lim DS

    更新日期:2007-03-01 00:00:00

  • Strategies to minimize bleeding complications of percutaneous coronary intervention.

    abstract:PURPOSE OF REVIEW:Bleeding has recently been identified as a major adverse outcome in patients with acute coronary syndromes. In this review, the importance of the association of bleeding with mortality and strategies to reduce bleeding with percutaneous coronary intervention are discussed. RECENT FINDINGS:Nine trials...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0b013e32832d1ea2

    authors: White HD

    更新日期:2009-07-01 00:00:00

  • Anomalous origins of the coronary arteries: current knowledge and future perspectives.

    abstract:PURPOSE OF REVIEW:The purpose of this review is to survey the contemporary literature surrounding congenital anomalies of origin of the coronary arteries and to identify remaining gaps in knowledge. RECENT FINDINGS:In recent years, lineage tracing analyses and mechanistic studies in model organisms have enhanced our u...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0000000000000663

    authors: Mazine A,Fernandes IM,Haller C,Hickey EJ

    更新日期:2019-09-01 00:00:00

  • The combination of obesity and hypertension: a highly unfavorable phenotype requiring attention.

    abstract:PURPOSE OF REVIEW:Body habitus is a key lifestyle characteristic whose current status and future projections are disconcerting. The percentage of the global population who are either overweight or obese has substantially increased, with no indication that any country has a solution to this issue. Hypertension is a key ...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0000000000000294

    authors: Arena R,Daugherty J,Bond S,Lavie CJ,Phillips S,Borghi-Silva A

    更新日期:2016-07-01 00:00:00

  • Will left-ventricular assist device therapy replace heart transplantation in the foreseeable future?

    abstract:PURPOSE OF REVIEW:Implantation of circulatory assist devices as a permanent alternative to heart transplantation, so-called Destination Therapy, has become a promising new option for treatment of patients with advanced heart failure who are not candidates for heart transplantation. RECENT FINDINGS:The landmark REMATCH...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/01.hco.0000153949.42189.03

    authors: Lietz K,Miller LW

    更新日期:2005-03-01 00:00:00

  • Does carotid intima media thickness indicate coronary atherosclerosis?

    abstract::Increased carotid intima media thickness (IMT) is relatively simple, inexpensive, and reproducible noninvasive marker of global atherosclerotic disease. It is a frequently used experimental tool in epidemiologic studies to identify and follow cardiovascular disease. There is evidence that early detection of atheroscle...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/00001573-200209000-00013

    authors: Sinha AK,Eigenbrodt M,Mehta JL

    更新日期:2002-09-01 00:00:00

  • Desensitization strategies in the patient awaiting heart transplantation.

    abstract:PURPOSE OF REVIEW:The aim of this review is to discuss the impact of antibody sensitization on heart transplant recipients. RECENT FINDINGS:We will discuss the current state of antibody identification, antibody strength and potential antibody pathogenicity. The prevalence of antibody sensitization has increased with i...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章

    doi:10.1097/HCO.0000000000000389

    authors: Chang DH,Kobashigawa JA

    更新日期:2017-05-01 00:00:00

  • Optimal revascularization strategies for multivessel coronary artery disease.

    abstract:PURPOSE OF REVIEW:The aim of this article is to review the current status of optimal revascularization strategies in patients presenting with multivessel coronary artery disease. RECENT FINDINGS:Coronary artery bypass surgery is the gold standard for patients with multivessel disease. Recent developments in the interv...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/01.hco.0000245738.40088.70

    authors: Daemen J,Serruys PW

    更新日期:2006-11-01 00:00:00

  • Sex differences in hypertrophic cardiomyopathy: new insights.

    abstract:PURPOSE OF REVIEW:Hypertrophic cardiomyopathy (HCM) is the most common genetic cardiomyopathy, diagnosed by left ventricular hypertrophy of at least 15 mm maximal wall thickness (MWT). Recent studies reported a sex difference in clinical presentation, progression and outcome of HCM. This review provides an overview of ...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0000000000000612

    authors: van Driel B,Nijenkamp L,Huurman R,Michels M,van der Velden J

    更新日期:2019-05-01 00:00:00

  • Molecular aspects of myocarditis.

    abstract::The mechanisms of pathogenesis of myocarditis have remained elusive. Despite the demonstration a decade ago that persistent viral infection of the myocardium occurred in many patients, a clear description of the pathologic progression has not been forthcoming. Over the past year, a number of studies have added to the ...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:

    authors: Bowles NE,Towbin JA

    更新日期:1998-05-01 00:00:00

  • Aortic valve disease.

    abstract::Management of aortic valve disease follows traditional algorithms: initial gross diagnosis, noninvasive imaging and quantitation, possible catheterization or angiography, and medical treatment until symptoms of prognosis prediction indicates surgery. Most advances in this subject reflect improved technology and additi...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/00001573-199403000-00003

    authors: Baxley WA

    更新日期:1994-03-01 00:00:00

  • Adenosine single photon emission computed tomography for assessing risk after myocardial infarction: recent developments.

    abstract:PURPOSE OF REVIEW:While the prognostic power of adenosine single photon emission computed tomography myocardial perfusion imaging has been validated in multiple patient populations including those with known or suspected coronary artery disease, the utility of this modality in assessing risk after an acute myocardial i...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0b013e32820652c9

    authors: Dorfman TA,Iskandrian AE

    更新日期:2007-09-01 00:00:00

  • Genetic risk stratification in cardiac arrhythmias.

    abstract:PURPOSE OF REVIEW:The current article provides a concise summary of the possibilities and limitations of genotype-based risk stratification of cardiac arrhythmias. We will outline the most important findings of the recent years in the light of their chronological and conceptual development. RECENT FINDINGS:Genotype-ph...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0000000000000506

    authors: Napolitano C,Mazzanti A,Priori SG

    更新日期:2018-05-01 00:00:00

  • Tissue Doppler imaging for evaluation of myocardial function in patients with diabetes mellitus.

    abstract:PURPOSE OF REVIEW:Heart failure and diabetes mellitus are frequently associated, and diabetes appears to potentiate the clinical presentation of heart failure related to other causes. The purpose of this review is to examine recent advances in the application of tissue Doppler imaging for the assessment of diabetic hea...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/01.hco.0000131535.32657.87

    authors: Marwick TH

    更新日期:2004-09-01 00:00:00

  • Tilt-table testing and syncope.

    abstract::Syncope is a common clinical problem with multiple potential causes. Recent studies have delineated the natural history and most frequent causes of recurrent syncopal episodes. The medical history and detailed physical examination are particularly important. Clinical electrophysiologic testing has also played a crit...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:

    authors: Benditt DG,Asso A,Remole S,Lurie K

    更新日期:1992-02-01 00:00:00

  • New strategies in myocardial preservation.

    abstract::Myocardial protection seems to be evolving toward simplified techniques, among which the use of minimally diluted tepid blood cardioplegia delivered retrograde or in a combined fashion is gaining wider clinical acceptance. In the future, agents that can duplicate the cardioprotective effects of ischemic preconditionin...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/00001573-199711000-00002

    authors: Menasché P

    更新日期:1997-11-01 00:00:00

  • Management of combined carotid and coronary artery disease.

    abstract::Although it has been the topic of intense medical and surgical attention for over 20 years, the coexistence of severe carotid artery disease in patients undergoing coronary artery bypass graft continues to be a major cause of perioperative morbidity and mortality. Refinements in diagnostic modalities, mainly by duplex...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/00001573-199609000-00012

    authors: Schepens MA,Vermeulen FE

    更新日期:1996-09-01 00:00:00

  • Omega-3 fatty acid therapy for cardiovascular disease: justified or not?

    abstract:PURPOSE OF REVIEW:To discuss the current evidence regarding the relationship between omega-3 fatty acid intake and atherosclerotic cardiovascular disease (ASCVD) risk. RECENT FINDINGS:Combined results from randomized controlled trials using low-dosage (≤1.8 g/day of ethyl esters) eicosapentaenoic acid (EPA) or EPA + d...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章

    doi:10.1097/HCO.0000000000000741

    authors: Maki KC,Dicklin MR

    更新日期:2020-07-01 00:00:00

  • How to avoid inappropriate therapy.

    abstract:PURPOSE OF REVIEW:With wider indications for implantable cardioverter defibrillator therapy, more patients at lower risk for ventricular tachyarrhythmia receive this treatment. To maintain the ratio of benefit versus side-effects at an acceptable level, the risk of inappropriate implantable cardioverter defibrillator t...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0b013e3282f30436

    authors: Israel CW

    更新日期:2008-01-01 00:00:00

  • Minimally invasive pediatric cardiac surgery.

    abstract::Minimally invasive cardiac surgery has evolved in response to the intrinsic irony facing cardiac surgeons: that we must injure our patients to treat them. In recent years, advances in fiberoptic imaging technology, applied to other surgical specialties, suggested the possibility that cardiac surgery might also be perf...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/00001573-199901000-00011

    authors: Burke RP

    更新日期:1999-01-01 00:00:00

  • Prosthetic valve selection in patients with left-sided endocarditis: bioprosthetic or mechanical valves?

    abstract:PURPOSE OF REVIEW:Studies comparing outcomes in left-sided endocarditis based on the prosthesis selected for implantation are limited and no randomized studies have been performed. The purpose of this review is to summarize the best available studies to determine what prosthesis is most appropriate when valve replaceme...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0000000000000040

    authors: Moon MR

    更新日期:2014-03-01 00:00:00

  • Fibrosis and hypertensive heart disease.

    abstract::The normal myocardium is composed of a variety of cells: cardiac myocytes and noncardiomyocytes, which include endothelial and vascular smooth muscle cells and fibroblasts. Hypertensive heart disease involves a structural remodeling of muscular and nonmuscular compartments. It is not the quantity but rather the qualit...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/00001573-200007000-00010

    authors: Weber KT

    更新日期:2000-07-01 00:00:00

  • Culture, teamwork and engagement: 40 years of finding the right ingredients.

    abstract:PURPOSE OF REVIEW:Changing demands in healthcare, new leadership structures and physician preferences on work-life balance have made culture, teamwork and engagement vitally important for the long-term success of medical practices. With recent emphasis placed on culture, teamwork and engagement, leaders have had to acq...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章

    doi:10.1097/HCO.0000000000000805

    authors: Samai C,Campbell R

    更新日期:2021-01-01 00:00:00

  • Update on digoxin and other oral positive inotropic agents for chronic heart failure.

    abstract::The benefit of digoxin in chronic heart failure has been debated fervently for decades. In the 1970s, the use of digoxin was challenged due to the high incidences of digitalis toxicity and the lack of data on the effects of digoxin in patients with chronic heart failure. In the 1980s, interest in digoxin was renewed a...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/00001573-199705000-00004

    authors: Reddy S,Benatar D,Gheorghiade M

    更新日期:1997-05-01 00:00:00

  • New surgical therapies for heart failure.

    abstract::A growing number of patients present with heart failure. Some of them may qualify for surgical correction of their cardiac condition. Since heart transplantation will always be available to only a small number of patients, several new surgical techniques have been developed for approval in heart failure patients. Clas...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/00001573-200305000-00004

    authors: Loebe M,Soltero E,Thohan V,Lafuente JA,Noon GP

    更新日期:2003-05-01 00:00:00