Systematic review and meta-analysis in cardiac surgery: a primer.

Abstract:

PURPOSE OF REVIEW:The purpose of this article is to review the strengths and weaknesses of systematic reviews and meta-analyses to inform our current understanding of cardiac surgery. RECENT FINDINGS:A systematic review and meta-analysis of a focused topic can provide a quantitative estimate for the effect of a treatment intervention or exposure. In cardiac surgery, observational studies and small, single-center prospective trials provide most of the clinical outcomes that form the evidence base for patient management and guideline recommendations. As such, meta-analyses can be particularly valuable in synthesizing the literature for a particular focused surgical question. Since the year 2000, there are over 800 meta-analysis-related publications in our field. There are some limitations to this technique, including clinical, methodological and statistical heterogeneity, among other challenges. Despite these caveats, results of meta-analyses have been useful in forming treatment recommendations or in providing guidance in the design of future clinical trials. SUMMARY:There is a growing number of meta-analyses in the field of cardiac surgery. Knowledge translation via meta-analyses will continue to guide and inform cardiac surgical practice and our practice guidelines.

journal_name

Curr Opin Cardiol

authors

Yanagawa B,Tam DY,Mazine A,Tricco AC

doi

10.1097/HCO.0000000000000496

subject

Has Abstract

pub_date

2018-03-01 00:00:00

pages

184-189

issue

2

eissn

0268-4705

issn

1531-7080

journal_volume

33

pub_type

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