Evolving concepts on benefits and risks associated with therapeutic strategies to raise HDL.

Abstract:

PURPOSE OF REVIEW:To provide an update on high-density lipoprotein (HDL) biology and emerging new HDL-based therapies for athero-thrombosis. RECENT FINDINGS:Atherosclerotic cardiovascular disease remains a major public health threat despite a significant decline over the past three decades. Although current medical therapies, specifically low-density lipoprotein lowering with statins, reduce cardiovascular events by about 25-35%, a substantial residual risk remains, leading to a search for additional therapeutic interventions. In this regard, HDL has emerged as one important target because of epidemiologic evidence linking HDL levels inversely to cardiovascular events, known vascular protective actions of HDL and experimental and clinical research supporting athero-protective actions of HDL. However, complexities of HDL composition, particle size, and metabolism have suggested that HDL functionality, and how HDL is increased, may be important determinants of its protective effects. SUMMARY:Thus the possibility that HDL modification could address the residual risk has brought renewed focus on an old HDL-raising drug, niacin, and a number of newer strategies to exploit the vascular benefits of HDL.

journal_name

Curr Opin Cardiol

authors

Shah PK

doi

10.1097/HCO.0b013e32833f0382

subject

Has Abstract

pub_date

2010-11-01 00:00:00

pages

603-8

issue

6

eissn

0268-4705

issn

1531-7080

journal_volume

25

pub_type

杂志文章,评审
  • Contemporary management of pericardial diseases.

    abstract:PURPOSE OF REVIEW:Pericardial diseases are relatively common in clinical practice, either as isolated disease or as manifestation of a systemic disorder. The aim of the present study is to review more recent updates on their contemporary management. RECENT FINDINGS:The cause of pericardial diseases is varied according...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0b013e3283524fbe

    authors: Imazio M

    更新日期:2012-05-01 00:00:00

  • Management of aortic dissection.

    abstract::Patients with aortic dissection are divided into two main groups: those with hypertension and those with syndromes involving hereditary defects of the aortic wall. The common finding in the setting of both Marfan syndrome and hypertension is dilatation of the aorta. The biological events that may lead to dissection ar...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:

    authors: Westaby S

    更新日期:1995-09-01 00:00:00

  • Vagal stimulation for heart failure.

    abstract:PURPOSE OF REVIEW:On the very solid background of experimental and clinical studies pointing to the cardiovascular risks associated with depressed vagal reflexes and supported by specific experiments in animal models of heart failure, we are witnessing a rapidly growing interest in the very untraditional approach to th...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0b013e3283413961

    authors: Schwartz PJ

    更新日期:2011-01-01 00:00:00

  • Hybrid palliation in hypoplastic left heart syndrome.

    abstract:PURPOSE OF REVIEW:Despite progressive improvement in surgical results, hypoplastic left heart syndrome remains one of the congenital heart abnormalities with the greatest morbidity and mortality. Hybrid approaches to management, combining surgical and interventional catheterization procedures, have been introduced to m...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0b013e328014d945

    authors: Gutgesell HP,Lim DS

    更新日期:2007-03-01 00:00:00

  • Evidence supporting secondary prevention strategies.

    abstract::Currently 14 million individuals in the United States have coronary disease. Within the next 2 decades, this number is expected to increase to 21 million persons. To minimize the excessive risk of recurrent cardiac events in these people, evidence-based, cost-effective prevention strategies must be developed. This rev...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/00001573-199907000-00005

    authors: Blazing MA,O'Connor CM

    更新日期:1999-07-01 00:00:00

  • Low-density lipoprotein-lowering strategies: target versus maximalist versus population percentile.

    abstract:PURPOSE OF REVIEW:Maximalist low-density lipoprotein (LDL)-lowering strategies such as lowering LDL as much as possible or, alternatively, using the most potent LDL-lowering regimens have become increasingly popular. Almost all attention has focused on the potential advantages of these approaches with little focus on t...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0b013e328353fed5

    authors: Sniderman AD,De Graaf J,Couture P

    更新日期:2012-07-01 00:00:00

  • Cybersecurity threats to cardiac implantable devices: room for improvement.

    abstract:PURPOSE OF REVIEW:For over a decade, vulnerabilities in the healthcare industry have been identified. Medical devices such as cardiovascular implantable electronic devices (CIEDs) are particularly concerning because of direct threats to patient safety and protected health information (PHI). Although these vulnerabiliti...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章

    doi:10.1097/HCO.0000000000000815

    authors: Tomaiko E,Zawaneh MS

    更新日期:2021-01-01 00:00:00

  • Penetrating atherosclerotic ulcer.

    abstract:PURPOSE OF REVIEW:Penetrating aortic ulcer (PAU) is defined as ulceration of an aortic atherosclerotic plaque penetrating through the internal elastic lamina into the media. With the advances in imaging techniques, the differential diagnosis between PAU and other aortic ulcers remains a challenge. This review aims to s...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0000000000000782

    authors: Evangelista A,Moral S

    更新日期:2020-11-01 00:00:00

  • Use of implantable pacemakers and implantable defibrillators in hypertrophic cardiomyopathy.

    abstract::Recent data have emerged to help guide the use of implantable pacemakers and implantable defibrillators in patients who have hypertrophic cardiomyopathy (HCM). Controlled studies of the use of dual chamber pacemakers to treat outflow tract obstruction in HCM have shown little benefit, and have raised the possibility t...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/00001573-200101000-00009

    authors: Freedman RA

    更新日期:2001-01-01 00:00:00

  • Pulmonary embolism: impact of right ventricular dysfunction.

    abstract:PURPOSE OF REVIEW:The appropriate treatment of patients with acute pulmonary embolism who present with right ventricular dysfunction but normal arterial blood pressure, and particularly the potential benefits of thrombolytic treatment in this setting, continue to be highly controversial. In the past year, several well ...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/01.hco.0000179818.65329.bb

    authors: Konstantinides S

    更新日期:2005-11-01 00:00:00

  • The role of antiplatelet therapy in the secondary prevention of coronary artery disease.

    abstract:PURPOSE OF REVIEW:In this study, we review the evidence for both long-standing and newer oral antiplatelet agents as secondary prevention in coronary artery disease, and give our opinion on where each agent's treatment role lies. RECENT FINDINGS:Platelets play a pathological role in acute coronary syndromes and are th...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0b013e328338f7b5

    authors: Behan MW,Chew DP,Aylward PE

    更新日期:2010-07-01 00:00:00

  • The role of tricuspid valve repair and replacement in right heart failure.

    abstract:PURPOSE OF REVIEW:The presence of tricuspid regurgitation in the setting of right ventricular dysfunction is associated with poor prognosis. The purpose of this review is to describe the pathophysiology of functional tricuspid regurgitation, summarize the current reports favoring a more aggressive approach toward tricu...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0b013e3283512051

    authors: Pinney SP

    更新日期:2012-05-01 00:00:00

  • Nutraceuticals and coronary heart disease.

    abstract:PURPOSE OF REVIEW:Although many reviews have focused on diet as a determinant of coronary heart disease (CHD), little is known about the use of specific nutrients or food products. The aim of this review was to examine the role of several functional foods, or nutraceuticals, in the prevention or treatment of CHD. RECE...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0b013e32836081a5

    authors: Garcia-Rios A,Delgado-Lista J,Alcala-Diaz JF,Lopez-Miranda J,Perez-Martinez P

    更新日期:2013-07-01 00:00:00

  • Revascularization for patients with diabetes mellitus and stable ischemic heart disease: an update.

    abstract:PURPOSE OF REVIEW:To provide an update on the management of patients with diabetes mellitus and requiring coronary revascularization. RECENT FINDINGS:Evidence continues to show that patients with diabetes mellitus and ischemic heart disease represent a very high-risk group of patients. Choice of stent appears importan...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章

    doi:10.1097/HCO.0000000000000421

    authors: Mancini GBJ,Farkouh M,Verma S

    更新日期:2017-09-01 00:00:00

  • Next-generation sequencing to identify genetic causes of cardiomyopathies.

    abstract:PURPOSE OF REVIEW:This review examines the application of next-generation sequencing (NGS) technologies in the identification of the causation of nonsyndromic genetic cardiomyopathies. RECENT FINDINGS:NGS sequencing of the entire genetic coding sequence (the exome) has successfully identified five novel genes and caus...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0b013e328352207e

    authors: Norton N,Li D,Hershberger RE

    更新日期:2012-05-01 00:00:00

  • Lung transplantation in children.

    abstract::Fewer than 50 pediatric lung transplants are performed each year. Surgical advances in the field have resulted in improved operative outcomes and in technical innovations that have broadened both the target population and the donor pool. At the same time, late referral of critically ill patients and shortage of donor ...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/00001573-199801000-00012

    authors: Bridges ND

    更新日期:1998-01-01 00:00:00

  • The added value of simultaneous myocardial perfusion and left ventricular function.

    abstract::The focus of this review is the advantages of simultaneously assessing myocardial perfusion and left ventricular function. Nuclear cardiology imaging techniques as well as the development of technetium-labeled perfusion tracers now permit combined myocardial-perfusion and left-ventricular function studies at a single ...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/00001573-199911000-00002

    authors: Borges-Neto S,Shaw LK

    更新日期:1999-11-01 00:00:00

  • Cardiac allograft vasculopathy: pathology, prevention and treatment.

    abstract:PURPOSE OF REVIEW:Cardiac transplantation is a recognized therapy for end-stage heart failure. Graft coronary artery disease is a chief determinant of long-term survival following cardiac transplantation. There are multiple purported etiologies for graft coronary artery disease including both immunologic and nonimmunol...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/01.hco.0000203184.89158.16

    authors: Kass M,Haddad H

    更新日期:2006-03-01 00:00:00

  • Desensitization strategies in the patient awaiting heart transplantation.

    abstract:PURPOSE OF REVIEW:The aim of this review is to discuss the impact of antibody sensitization on heart transplant recipients. RECENT FINDINGS:We will discuss the current state of antibody identification, antibody strength and potential antibody pathogenicity. The prevalence of antibody sensitization has increased with i...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章

    doi:10.1097/HCO.0000000000000389

    authors: Chang DH,Kobashigawa JA

    更新日期:2017-05-01 00:00:00

  • Late deaths after Fontan procedure: the next frontier.

    abstract:PURPOSE OF REVIEW:It has been more than 4 decades since the development of Fontan operation. With the contemporary surgical strategies to treat the patients with a single ventricle physiology, the medium-term survival of the patients following Fontan operation is excellent. Nonetheless, the Fontan circulation with a pu...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0000000000000603

    authors: Luo S,Honjo O

    更新日期:2019-03-01 00:00:00

  • Myocardial contrast echocardiography in acute coronary syndromes.

    abstract::Myocardial contrast echocardiography (MCE) is an emerging technique in which microbubble contrast agents are visualized in the coronary microvasculature. MCE is an ideal modality for the noninvasive evaluation of acute coronary syndromes because it provides portable, simultaneous assessment of regional wall motion and...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/00001573-200209000-00003

    authors: Ward RP,Lang RM

    更新日期:2002-09-01 00:00:00

  • Current and novel biomarkers in heart failure: bench to bedside.

    abstract:PURPOSE OF REVIEW:Natriuretic peptides, high-sensitivity cardiac troponins, and suppression of tumorigenicity 2 are novel biomarkers that reflect the intricate pathophysiology of heart failure and can thus be used for the diagnosis, management, and prognosis of heart failure. RECENT FINDINGS:This review article descri...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0000000000000254

    authors: Ghashghaei R,Arbit B,Maisel AS

    更新日期:2016-03-01 00:00:00

  • Future of interventional cardiology in pediatrics.

    abstract::A trend toward use of less invasive, nonsurgical approaches to the treatment of congenital heart disease has developed. Although transcatheter valve replacements and ventricular septal defect closures have already been performed in children, many other techniques and devices are being developed for the palliation of c...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/00001573-200303000-00002

    authors: Levi DS,Alejos JC,Moore JW

    更新日期:2003-03-01 00:00:00

  • Long-lasting benefits of exercise for those living with a Fontan circulation.

    abstract:PURPOSE OF REVIEW:In recent decades, the physiology and late outcomes of the Fontan circulation have become better characterized and interest has turned to interventions that might improve exercise capacity and clinical sequelae. No therapy has currently been shown to be more effective for improving exercise capacity i...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0000000000000582

    authors: Cordina R,d'Udekem Y

    更新日期:2019-01-01 00:00:00

  • Fibrates in the treatment of cardiovascular risk and atherogenic dyslipidaemia.

    abstract:PURPOSE:New data have emerged over the last few years about the role of fibrates in treatment of microvascular and macrovascular disease. RECENT FINDINGS:Endpoint studies have been conducted with fibrates in coronary heart disease (CHD) since 1971 and initial results were contradictory. Fibrates later showed benefits ...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0b013e32832c0b3d

    authors: Wierzbicki AS

    更新日期:2009-07-01 00:00:00

  • Imaging and heart failure: myocardial strain.

    abstract:PURPOSE OF REVIEW:To summarize literature on the application of myocardial strain in patients with heart failure published since 2018. RECENT FINDINGS:Left ventricular (LV) and right ventricular strain provides important prognostic information in patients with acute and chronic heart failure and new insights in diseas...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0000000000000653

    authors: Edvardsen T,Klaeboe LG

    更新日期:2019-09-01 00:00:00

  • Congenital heart surgery.

    abstract::In reviewing selected publications on congenital heart disease management for 1990 and 1991, some topics have been chosen for discussion, including isolated patent ductus arteriosus, coarctation of the aorta, critical aortic stenosis in early infancy, hypoplastic left-heart syndrome, pulmonary artery banding, Fontan p...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/00001573-199204000-00010

    authors: Mee RB

    更新日期:1992-04-01 00:00:00

  • Diet as preventive medicine in cardiology.

    abstract::Because the main cause of death in patients with established coronary heart disease (CHD) is sudden cardiac death (SCD), physicians should develop specific strategy, including dietary changes, to prevent it. In the long term, reduction of the diet-dependent chronic risk factors of CHD, hypercholesterolemia, hypertensi...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/00001573-200009000-00009

    authors: de Lorgeril M,Salen P

    更新日期:2000-09-01 00:00:00

  • Pediatric cardiac electrophysiology.

    abstract::Over the past year, many advances have been made in the management of cardiac arrhythmias in the pediatric patient. It has become evident that the new surgical procedures for congenital cardiac disease can result in arrhythmia-associated morbidity and mortality. New pharmacologic agents such as adenosine have been s...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/00001573-199102000-00016

    authors: Kaminer SJ,Gelband H

    更新日期:1991-02-01 00:00:00

  • Sex differences in hypertrophic cardiomyopathy: new insights.

    abstract:PURPOSE OF REVIEW:Hypertrophic cardiomyopathy (HCM) is the most common genetic cardiomyopathy, diagnosed by left ventricular hypertrophy of at least 15 mm maximal wall thickness (MWT). Recent studies reported a sex difference in clinical presentation, progression and outcome of HCM. This review provides an overview of ...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0000000000000612

    authors: van Driel B,Nijenkamp L,Huurman R,Michels M,van der Velden J

    更新日期:2019-05-01 00:00:00