Desensitization strategies in the patient awaiting heart transplantation.

Abstract:

PURPOSE OF REVIEW:The aim of this review is to discuss the impact of antibody sensitization on heart transplant recipients. RECENT FINDINGS:We will discuss the current state of antibody identification, antibody strength and potential antibody pathogenicity. The prevalence of antibody sensitization has increased with increased utilization of mechanical circulatory support (MCS). Data on MCS-related antibody sensitization are reviewed. Important considerations to minimize the prozone effect in antibody testing will be discussed. We present an overview of strategies for desensitization in solid organ transplantation. Current protocols for desensitization therapies will be presented. Finally, future research avenues, including potential further refinement of the detection of human leukocyte antigen (HLA) epitopes to improve donor-recipient immunologic matching, future direction for prevention of donor-specific antibodies (DSAs), the potential role of non-HLA antibodies and further potential refinement of the immune system for management of sensitized patient will be proposed. SUMMARY:Antibody sensitization is a key immunologic issue prior to and after heart transplantation. Therapies aimed at immunomodulation, termed desensitization strategies, may improve immunologic matching at the time of heart transplantation.

journal_name

Curr Opin Cardiol

authors

Chang DH,Kobashigawa JA

doi

10.1097/HCO.0000000000000389

subject

Has Abstract

pub_date

2017-05-01 00:00:00

pages

301-307

issue

3

eissn

0268-4705

issn

1531-7080

journal_volume

32

pub_type

杂志文章
  • Will new higher-precision troponins lead to clarity or confusion?

    abstract:PURPOSE OF REVIEW:Troponins are a cornerstone for the diagnosis of myocardial infarction, assessment of risk and prognosis, and determination of antithrombotic and a revascularization strategy in patients with acute coronary syndromes. Newer assays with higher precision for detection of troponin levels are about to ent...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0b013e3283050808

    authors: White HD

    更新日期:2008-07-01 00:00:00

  • Primary prevention of heart failure: what is the evidence?

    abstract:PURPOSE OF REVIEW:Heart failure is a worldwide epidemic. Aggressive treatment of patients at risk for heart failure is important. There are no trials targeting primary prevention of heart failure. However, there is trial data demonstrating that treatment of patients with atherosclerotic vascular disease, hypertension, ...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0b013e3283207aee

    authors: Dupree CS

    更新日期:2009-03-01 00:00:00

  • Long-term results of coronary artery bypass grafting.

    abstract::The treatment of ischemic heart disease by coronary artery bypass grafting remains under intense scrutiny. A better understanding of the long-term outcome for particular patient subgroups will allow a more appropriate choice to be made among the options of coronary artery bypass grafting, angioplasty, or continued med...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/00001573-199611000-00003

    authors: Kanagasabay RR,Parker DJ

    更新日期:1996-11-01 00:00:00

  • Trials comparing coronary artery bypass grafting with percutaneous transluminal coronary angioplasty and primary stent implantation in patients with multivessel coronary artery disease.

    abstract::With marked improvements in stent technology as adjunct to balloon angioplasty for multivessel coronary disease, several newer trials are currently in progress reviewing the optimal revascularization strategy. This review provides background from older studies and addresses the current progress and design of these new...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/00001573-200011000-00003

    authors: Bakhai A,Stables RH,Prasad S,Sigwart U

    更新日期:2000-11-01 00:00:00

  • Thrombolytic therapy in acute pulmonary embolism.

    abstract:PURPOSE OF REVIEW:The goal of this review is to offer an overview of the use of thrombolytic therapy in acute pulmonary embolism. Clinicians including internists, surgeons, pulmonologists, and other specialists continue to face decisions regarding massive and submassive acute pulmonary embolism in their daily routines....

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0b013e328358308c

    authors: Tapson VF

    更新日期:2012-11-01 00:00:00

  • Five decades of pediatric heart transplantation: challenges overcome, challenges remaining.

    abstract:PURPOSE OF REVIEW:Pediatric heart transplants continue to be the therapy of choice for children with end stage heart failure. The interplay of limited donor supply, improvement in ventricular assist device (VAD) technology and utilization, and a focus on optimizing long-term outcomes make it critically important for pr...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0000000000000351

    authors: Zangwill S

    更新日期:2017-01-01 00:00:00

  • How to avoid inappropriate therapy.

    abstract:PURPOSE OF REVIEW:With wider indications for implantable cardioverter defibrillator therapy, more patients at lower risk for ventricular tachyarrhythmia receive this treatment. To maintain the ratio of benefit versus side-effects at an acceptable level, the risk of inappropriate implantable cardioverter defibrillator t...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0b013e3282f30436

    authors: Israel CW

    更新日期:2008-01-01 00:00:00

  • Nutrition and physical activity recommendations from the United States and European cardiovascular guidelines: a comparative review.

    abstract:PURPOSE OF REVIEW:A healthy lifestyle throughout one's lifespan is the core foundation for both primary and secondary prevention of cardiovascular disease (CVD). Risk-based decisions for pharmacological therapy is added on-top of lifestyle management. Thus, understanding lifestyle-based recommendations is central to CV...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0000000000000763

    authors: Ferraro RA,Fischer NM,Xun H,Michos ED

    更新日期:2020-09-01 00:00:00

  • Percutaneous valve replacement: a paradigm shift.

    abstract:PURPOSE OF REVIEW:Valvular heart disease is often associated with significant morbidity and mortality. Surgical treatment of stenotic or regurgitant valvular lesions can alter the natural history of the disease process, yielding excellent short and long-term results, meaning that this has been accepted as the gold stan...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章

    doi:10.1097/HCO.0b013e3282a14dc8

    authors: Sinha AK,Kini AS,Sharma SK

    更新日期:2007-09-01 00:00:00

  • Pediatric cardiac electrophysiology.

    abstract::Over the past year, many advances have been made in the management of cardiac arrhythmias in the pediatric patient. It has become evident that the new surgical procedures for congenital cardiac disease can result in arrhythmia-associated morbidity and mortality. New pharmacologic agents such as adenosine have been s...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/00001573-199102000-00016

    authors: Kaminer SJ,Gelband H

    更新日期:1991-02-01 00:00:00

  • Genes, hypertension, and intermediate phenotypes.

    abstract::Although it has been recognized for almost 70 years that there is a substantial genetic component to the pathogenesis of hypertension, only recently have systematic efforts been made to identify the responsible genetically determined mechanisms. In the case of several rare syndromes, spectacular progress has been made...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/00001573-199609000-00002

    authors: Hollenberg NK

    更新日期:1996-09-01 00:00:00

  • Recent advances in stress echocardiography.

    abstract:PURPOSE OF REVIEW:This article reviews the recent advances in stress echocardiography, with particular attention to articles published in 2010 and 2011. It summarizes the developments in the diagnostic and prognostic capabilities of stress echocardiography, discusses new data regarding the safety of stress echocardiogr...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0b013e328349035b

    authors: Cullen MW,Pellikka PA

    更新日期:2011-09-01 00:00:00

  • Innovations in cardiac transplantation.

    abstract:PURPOSE OF REVIEW:As the number of people living with heart failure continues to grow, future treatments will focus on efficient donor organ donation and ensuring safe and durable outcomes. This review will focus on organ procurement, graft surveillance and emerging therapies. RECENT FINDINGS:Preliminary studies into ...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章

    doi:10.1097/HCO.0000000000000392

    authors: Hasan R,Ela AAE,Goldstein D

    更新日期:2017-05-01 00:00:00

  • An update in the management of acute decompensated heart failure.

    abstract:PURPOSE OF REVIEW:This review will provide an overview of recent advances in the management of acute decompensated heart failure, focusing on major publications from the past few years. RECENT FINDINGS:There have been several publications investigating different strategies in the management of acute decompensated hear...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0000000000000038

    authors: Maze R,Haddad H

    更新日期:2014-03-01 00:00:00

  • Assessment of myocardial viability by PET.

    abstract:PURPOSE OF REVIEW:Viability assessment has a key role in the management of patients with ischemic heart disease. Positron emission tomography (PET) is a unique modality that evaluates myocardial viability via assessing the tissues metabolic and perfusion properties. The mainstay of metabolic imaging relies on glucose m...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0000000000000652

    authors: Khalaf S,Chamsi-Pasha M,Al-Mallah MH

    更新日期:2019-09-01 00:00:00

  • Cardiac connexins as candidate genes for idiopathic atrial fibrillation.

    abstract:PURPOSE OF REVIEW:Atrial fibrillation is the most common sustained cardiac arrhythmia and may cause significant morbidity. Current management strategies offer only modest success and may be associated with intolerable drug side effects or risk of procedural complications. As with other cardiac arrhythmias, the identifi...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/01.hco.0000221574.95383.6f

    authors: Gollob MH

    更新日期:2006-05-01 00:00:00

  • Complex aortic arch aneurysm and dissections: hybrid techniques for surgical and endovascular therapy.

    abstract:PURPOSE OF REVIEW:Open aortic arch surgery is highly invasive and may result in significant morbidity. Recent innovations in thoracic stent-graft technology have facilitated methods of replacing the aortic arch without deep hypothermic circulatory arrest or even cardiopulmonary bypass. We present a review of the curren...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0b013e3283317c91

    authors: Desai ND,Szeto WY

    更新日期:2009-11-01 00:00:00

  • Medical treatment of valvular heart disease.

    abstract::Despite recent advances in operative and percutaneous surgical techniques for valvular heart disease, medical management of complications of valvular disease, such as atrial fibrillation and infection, and prevention of thromboembolism remain important clinical problems. This review discusses recent data that address...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/00001573-199104000-00005

    authors: Hoit BD

    更新日期:1991-04-01 00:00:00

  • Future pharmacological therapy in hypertension.

    abstract:PURPOSE OF REVIEW:Hypertension (HTN) is a widespread and growing disease, with medication intolerance and side-effect present among many. To address these obstacles novel pharmacotherapy is an active area of drug development. This review seeks to explore future drug therapy for HTN in the preclinical and clinical arena...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0000000000000529

    authors: Stewart MH,Lavie CJ,Ventura HO

    更新日期:2018-07-01 00:00:00

  • Bilateral internal thoracic arteries: what is the State of the ART?

    abstract:PURPOSE OF REVIEW:To provide a broad overview of the current state of knowledge of coronary artery bypass grafting with bilateral internal thoracic artery (BITA). RECENT FINDINGS:There exists a large body of literature from mostly observational studies supporting the use of BITA in patients undergoing coronary artery ...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0000000000000431

    authors: Yanagawa B,Verma S,Puskas JD

    更新日期:2017-09-01 00:00:00

  • The risks and benefits of transseptal endocardial pacing.

    abstract:PURPOSE OF REVIEW:Transseptal endocardial left-ventricular pacing has a number of potential advantages over left-ventricular epicardial pacing from the coronary sinus, for implantation of cardiac resynchronization therapy (CRT) devices. In this study we review the risks and potential benefits. RECENT FINDINGS:Permanen...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0b013e32834dc3d4

    authors: Whinnett Z,Bordachar P

    更新日期:2012-01-01 00:00:00

  • Walking: the first steps in cardiovascular disease prevention.

    abstract:PURPOSE OF REVIEW:Health professionals are presented with the challenge of prescribing physical activity that is likely to be sustained by the sedentary majority. Walking is eminently suited to physical activity prescription for inactive individuals as it is accessible to men and women of all ages and social groups and...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0b013e32833ce972

    authors: Murtagh EM,Murphy MH,Boone-Heinonen J

    更新日期:2010-09-01 00:00:00

  • The molecular genetics of congenital heart disease: a review of recent developments.

    abstract:PURPOSE OF REVIEW:Our understanding of the interactions of genes and pathways during heart development continues to expand with our knowledge of the genetic basis of congenital heart disease. Along with the discovery of specific genes that cause lesions, recent research has focused on the interactions of some previousl...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0b013e328337b4ce

    authors: Wolf M,Basson CT

    更新日期:2010-05-01 00:00:00

  • Catheter cryoablation of cardiac arrhythmias.

    abstract:PURPOSE OF REVIEW:The purpose of the review is to provide an update on the safety and efficacy of catheter cryoablation. RECENT FINDINGS:Catheter cryoablation is a safe and clinically effective method for ablation of atrioventricular nodal reentrant supraventricular tachycardia. Although the acute procedural success r...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:

    authors: Friedman PL

    更新日期:2005-01-01 00:00:00

  • Myocardial viability in patients with coronary artery disease and left ventricular dysfunction: transplantation or revascularization?

    abstract::Coronary artery bypass surgery performed in patients with coronary artery disease and left ventricular dysfunction improves survival compared with antianginal therapy alone. The mechanisms for this survival advantage with revascularization therapy have not been systematically elucidated. Many of these patients have "h...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/00001573-199607000-00008

    authors: DeNofrio D,Loh E

    更新日期:1996-07-01 00:00:00

  • New or developing antihypertensive agents.

    abstract::Although significant pharmacologic and nonpharmacologic advances in treating hypertension during the last decade have reduced mortality and morbidity, hypertension continues to be a major health concern worldwide. Therefore, the search continues for newer specific pharmacologic treatment of this disorder. This review ...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:

    authors: Evans RR,DiPette DJ

    更新日期:1997-07-01 00:00:00

  • A new myocardial conversion of angiotensin I.

    abstract::The therapeutic benefits of angiotensin-converting enzyme inhibitors in the treatment of hypertension, congestive heart failure, and atherosclerotic heart disease are undeniable. Recent studies, however, suggest that the cardioprotective effect produced by these drugs is complex and may not be solely related to inhibi...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/00001573-199409000-00004

    authors: Ferrario CM,Chappell MC

    更新日期:1994-09-01 00:00:00

  • Advances in implantable cardioverter defibrillators.

    abstract::Implantable cardioverter defibrillators (ICDs) have become an important therapeutic modality for patients who have had a cardiac arrest or are at risk for life-threatening ventricular arrhythmias. Clinical trials have confirmed the role of the ICD for patients with sustained ventricular arrhythmias and have expanded t...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/00001573-200201000-00004

    authors: Swygman C,Wang PJ,Link MS,Homoud MK,Estes NA 3rd

    更新日期:2002-01-01 00:00:00

  • Arterial hypertension in children.

    abstract:PURPOSE OF REVIEW:Although arterial hypertension is less common in children than in adults, there is growing concern about elevated blood pressure (BP) in children and adolescents not only because of the association of elevated values with the overweight epidemic, but also as cardiovascular functions are determined in ...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0000000000000191

    authors: Santi M,Simonetti BG,Leoni-Foglia CF,Bianchetti MG,Simonetti GD

    更新日期:2015-07-01 00:00:00

  • Transmyocardial laser revascularization for inoperable coronary artery disease.

    abstract::Interest in transmyocardial laser revascularization for the treatment of otherwise inoperable coronary artery disease has increased rather dramatically in recent years. The results of several industrially sponsored clinical series have been reported recently, all with significant improvement in angina pectoris that ap...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:

    authors: Sundt TM 3rd,Rogers JG

    更新日期:1997-09-01 00:00:00