Update on digoxin and other oral positive inotropic agents for chronic heart failure.

Abstract:

:The benefit of digoxin in chronic heart failure has been debated fervently for decades. In the 1970s, the use of digoxin was challenged due to the high incidences of digitalis toxicity and the lack of data on the effects of digoxin in patients with chronic heart failure. In the 1980s, interest in digoxin was renewed after several trials with oral inotropic agents demonstrated increased mortality. Recently, several trials have studied the hemodynamic, neurohormonal, and clinical effects of digoxin, providing further insights into the possible mechanisms for its beneficial effects in patients with chronic heart failure. In an effort to find new pharmacologic therapies for the treatment of this patient population, studies of newer oral inotropic agents such as vesnarinone, pimobendan, and ibopamine have been disappointing. This paper reviews data published or presented in 1995 and 1996 examining the effects of digoxin and other oral inotropic agents in patients with chronic heart failure.

journal_name

Curr Opin Cardiol

authors

Reddy S,Benatar D,Gheorghiade M

doi

10.1097/00001573-199705000-00004

subject

Has Abstract

pub_date

1997-05-01 00:00:00

pages

233-41

issue

3

eissn

0268-4705

issn

1531-7080

journal_volume

12

pub_type

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