Abstract:
:We present a molecular system where polymerization is controlled externally by tuning the elastic energy of the monomers. The elastic energy, provided by a DNA molecular spring, destabilizes the monomer state through a process analogous to domain swapping. This energy can be large (of approximately 10 kT) and thus drive polymerization at relatively low monomer concentrations. The monomer-dimer equilibrium provides a measurement of the elastic energy of the monomer, which in this construction appears limited by kink formation in the DNA molecular spring, in accord with previous theoretical and experimental investigations of the elasticity of sharply bent DNA.
journal_name
Biophys Jjournal_title
Biophysical journalauthors
Wang A,Zocchi Gdoi
10.1016/j.bpj.2008.11.065subject
Has Abstractpub_date
2009-03-18 00:00:00pages
2344-52issue
6eissn
0006-3495issn
1542-0086pii
S0006-3495(09)00316-6journal_volume
96pub_type
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