Abstract：
:We carried out experiments on single isolated myofibrils in which thin filaments had been functionally removed, leaving the connecting (titin) filaments as the sole agent taking up the length change. With technical advances that gave sub-nanometer detectability we examined the time course of single sarcomere-length change when the myofibril was ramp-released or ramp-stretched by a motor. The sarcomere-length change was stepwise. Step sizes followed a consistent pattern: the smallest was approximately 2.3 nm, and others were integer multiples of that value. The approximately 2.3-nm step quantum is the smallest consistent biomechanical event ever demonstrated. Although the length change must involve the connecting filament, the size of the quantum is an order of magnitude smaller than anticipated from folding of Ig- or fibronectin-like domains, implying either that folding occurs in sub-domain units or that other mechanisms are involved.
journal_name
Biophys Jjournal_title
Biophysical journalauthors
Blyakhman F,Tourovskaya A,Pollack GHdoi
10.1016/S0006-3495(01)75766-9subject
Has Abstractpub_date
2001-08-01 00:00:00pages
1093-100issue
2eissn
0006-3495issn
1542-0086pii
S0006-3495(01)75766-9journal_volume
81pub_type
杂志文章abstract：:Singlet-triplet mixing in the initial radical-pair state, P[unk]I[unk], of photosynthetic bacterial reaction centers is due to the hyperfine mechanism at low magnetic fields and both the hyperfine and Deltag mechanisms at high magnetic fields (>1 kG). Since the hyperfine field felt by the electron spins in P[unk]I[unk...
journal_title：Biophysical journal
pub_type： 杂志文章
doi：10.1016/S0006-3495(87)83421-5
更新日期：1987-06-01 00:00:00
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journal_title：Biophysical journal
pub_type： 杂志文章
doi：10.1016/S0006-3495(03)70035-6
更新日期：2003-05-01 00:00:00
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journal_title：Biophysical journal
pub_type： 杂志文章
doi：10.1016/S0006-3495(91)82071-9
更新日期：1991-08-01 00:00:00
abstract：:The cell membrane having a transport system is inferred to be flexible when its function is being activated. For the brush border membrane vesicles prepared from rat small intestine, which have the co-transport system of Na+ and glucose, the membrane elasticity was measured as a function of the d-glucose concentration...
journal_title：Biophysical journal
pub_type： 杂志文章
doi：10.1016/S0006-3495(88)83130-8
更新日期：1988-04-01 00:00:00
abstract：:Trimethylamine-N-oxide (TMAO) in the cells of sharks and rays is believed to counteract the deleterious effects of the high intracellular concentrations of urea in these animals. It has been hypothesized that TMAO has the generic ability to counteract the effects of urea on protein structure and function, regardless o...
journal_title：Biophysical journal
pub_type： 杂志文章
doi：10.1016/S0006-3495(98)77972-X
更新日期：1998-05-01 00:00:00
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journal_title：Biophysical journal
pub_type： 杂志文章
doi：10.1016/j.bpj.2011.09.043
更新日期：2011-11-02 00:00:00
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journal_title：Biophysical journal
pub_type： 杂志文章
doi：10.1016/S0006-3495(90)82578-9
更新日期：1990-03-01 00:00:00
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journal_title：Biophysical journal
pub_type： 杂志文章
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更新日期：1997-07-01 00:00:00
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journal_title：Biophysical journal
pub_type： 杂志文章
doi：10.1016/j.bpj.2011.09.055
更新日期：2011-11-16 00:00:00
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pub_type： 杂志文章
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更新日期：2013-04-16 00:00:00
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journal_title：Biophysical journal
pub_type： 杂志文章
doi：10.1016/S0006-3495(03)74966-2
更新日期：2003-03-01 00:00:00
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journal_title：Biophysical journal
pub_type： 杂志文章
doi：10.1016/S0006-3495(73)85997-1
更新日期：1973-05-01 00:00:00
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journal_title：Biophysical journal
pub_type： 杂志文章
doi：10.1529/biophysj.104.047795
更新日期：2005-01-01 00:00:00
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journal_title：Biophysical journal
pub_type： 杂志文章
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更新日期：2019-09-03 00:00:00
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journal_title：Biophysical journal
pub_type： 杂志文章
doi：10.1016/S0006-3495(80)85028-4
更新日期：1980-12-01 00:00:00
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journal_title：Biophysical journal
pub_type： 杂志文章
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更新日期：2018-01-09 00:00:00
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journal_title：Biophysical journal
pub_type： 杂志文章
doi：10.1016/S0006-3495(65)86763-7
更新日期：1965-11-01 00:00:00
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journal_title：Biophysical journal
pub_type： 杂志文章
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更新日期：2010-07-07 00:00:00
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journal_title：Biophysical journal
pub_type： 杂志文章
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更新日期：1972-07-01 00:00:00
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journal_title：Biophysical journal
pub_type： 杂志文章
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更新日期：2018-05-08 00:00:00
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journal_title：Biophysical journal
pub_type： 杂志文章
doi：10.1529/biophysj.105.071621
更新日期：2006-05-15 00:00:00
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journal_title：Biophysical journal
pub_type： 杂志文章
doi：10.1016/j.bpj.2011.04.012
更新日期：2011-05-18 00:00:00
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journal_title：Biophysical journal
pub_type： 杂志文章
doi：10.1016/S0006-3495(78)85455-1
更新日期：1978-09-01 00:00:00
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journal_title：Biophysical journal
pub_type： 杂志文章
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更新日期：1992-12-01 00:00:00
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journal_title：Biophysical journal
pub_type： 杂志文章
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更新日期：2014-05-06 00:00:00
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journal_title：Biophysical journal
pub_type： 杂志文章
doi：10.1529/biophysj.105.065409
更新日期：2005-09-01 00:00:00
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journal_title：Biophysical journal
pub_type： 杂志文章
doi：10.1016/S0006-3495(87)83250-2
更新日期：1987-10-01 00:00:00
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journal_title：Biophysical journal
pub_type： 杂志文章
doi：10.1016/j.bpj.2008.09.062
更新日期：2009-02-18 00:00:00
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journal_title：Biophysical journal
pub_type： 杂志文章
doi：10.1016/j.bpj.2009.03.048
更新日期：2009-06-17 00:00:00
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journal_title：Biophysical journal
pub_type： 杂志文章
doi：10.1016/S0006-3495(67)86573-1
更新日期：1967-01-01 00:00:00
