Abstract:
:A simulation of the function of the human heart and heart muscle has been developed in the form of a digital computer code. For a given set of values for the input variables, realistic values of the cardiac output variables are predicted. A detailed discussion of the simulation and some results obtained from its application are presented. This simulation represents a unique combination of what was known in muscle mechanics, muscle thermodynamics, and of the structure, size, and shape of the heart, into an engineering model to improve the understanding of human heart muscle function. The left ventricle (LV) is treated as a thick-walled sphere whose wall is composed entirely of muscle fibers. Force-length velocity relationships are used to determine the tension in each fiber. The pressure in the LV is computed from fiber tension and fiber structure in the LV. A lumped-parameter simulation of the arterial tree provides a load impedance for the LV. Results are presented for simulation of normal human LV performance.
journal_name
Biophys Jjournal_title
Biophysical journalauthors
Hanna WTdoi
10.1016/S0006-3495(73)86011-4subject
Has Abstractpub_date
1973-07-01 00:00:00pages
603-21issue
7eissn
0006-3495issn
1542-0086pii
S0006-3495(73)86011-4journal_volume
13pub_type
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journal_title:Biophysical journal
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更新日期:2011-05-18 00:00:00
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更新日期:2007-07-15 00:00:00
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更新日期:2008-07-01 00:00:00
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更新日期:2007-09-01 00:00:00
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