Life cycle of yeast prions: propagation mediated by amyloid fibrils.

abstract：BACKGROUND:Malignant tumor is still one of the important diseases worldwide, cytotoxic CD8+ T lymphocytes (CTLs) play an important role in killing tumor cells. OBJECTIVE:To enhance the immune response of our previously identified HLA-A2-restricted CTL epitopes, we designed a multiepitope YL66. METHOD:The fusion prote...

journal_title：Protein and peptide letters

authors： Wu Y,Zhai W,Sun M,Zou Z,Zhou X,Li G,Yan Z,Qi Y,Gao Y

更新日期：2017-01-01 00:00:00

abstract：:Identification on protein folding types is always based on the 27-class folds dataset, which was provided by Ding & Dubchak in 2001. But with the avalanche of protein sequences, fold data is also expanding, so it will be the inevitable trend to improve the existing dataset and expand more folding types. In this paper,...

journal_title：Protein and peptide letters

authors： Liu L,Hu XZ,Liu XX,Wang Y,Li SB

更新日期：2012-04-01 00:00:00

abstract：:We report the stepwise transformation of a linear peptide epitope recognized by the anti-transforming growth factor alpha monoclonal antibody Tab2 into peptomers and finally into peptoid analogs. The key experiment in this study is the substitution analysis in which each position of the peptide is exchanged by a set o...

journal_title：Protein and peptide letters

authors： Hoffmann B,Ast T,Polakowski T,Reineke U,Volkmer R

更新日期：2006-01-01 00:00:00

abstract：:Antimicrobial peptides (AMPs) represent a large and ubiquitous group of peptides. The current crisis in antibiotic therapy has led to an intensified search for new antimicrobial agents. In this regard, scorpion venom constitutes a rich source of biologically active peptides including AMPs. In the present study, the pu...

journal_title：Protein and peptide letters

authors： Dueñas-Cuellar RA,Kushmerick C,Naves LA,Batista IF,Guerrero-Vargas JA,Pires OR Jr,Fontes W,Castro MS

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Ciprofloxacin (Cip) is the most commonly used quinolone in clinical practice; however large-scale use has favored the increase of multiresistant pathogenic microorganisms. Antimicrobial peptides (AMPs) appear to be a promising alternative in potentiating these conventional drugs. OBJECTIVE:The aim of this s...

journal_title：Protein and peptide letters

authors： Carneiro VA,de Oliveira ST,Silva RL,de Sousa Duarte H,Silva ML,Matos MNC,Cavalcante RMB,Figueira CS,Lorenzón EN,Cilli EM,da Cunha RMS

更新日期：2020-01-01 00:00:00

abstract：:Src is a non-receptor protein tyrosine kinase ubiquitously expressed in animals. It is involved in various cellular processes, including the innate immune response in mammals. However, less is known about the function of insect Src. Here we presented a homologue of Src in silkworm (Bombyx mori), named as BmSrc by phyl...

journal_title：Protein and peptide letters

authors： Li X,Hua X,Song L,Xia Q,Wang F

更新日期：2017-01-01 00:00:00

abstract：:The formation of local structure, in short peptides has been probed by examining cleavage patterns and rates of proteolysis of designed sequences with a high tendency to form beta-hairpin structures. Three model sequences which bear fluorescence donor and acceptor groups have been investigated: [see text]. Fluorescenc...

journal_title：Protein and peptide letters

authors： Saikumari YK,Ravindra G,Balaram P

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Searching the biomarker from complex heterogeneous material for early detection of disease is a challenging task in the field of biomedical sciences. OBJECTIVE:The study has been arranged to explore the proteomics serum derived profiling of the differential expressed and low molecular weight protein in brea...

journal_title：Protein and peptide letters

authors： Zafar A,Jabbar M,Manzoor Y,Gulzar H,Hassan SG,Nazir MA,Ain-Ul-Haq,Mustafa G,Sahar R,Masood A,Iqbal A,Hussain M,Hasan M

更新日期：2020-01-01 00:00:00

abstract：:Coiled coils are important structural modules and domains of protein-protein interactions. Further, they provide the required framework to proteins, like kinesins, myosins and SNAREs, which are either structural or involved in transport of biomolecules. We provide an interactive webserver to measure the strength of in...

journal_title：Protein and peptide letters

authors： Alva V,Syamala Devi DP,Sowdhamini R

更新日期：2008-01-01 00:00:00

abstract：:In the last few decades, novel drug delivery strategies have been a big priority to the formulation scientists. Peptides and proteins have drawn a special attention for their wide scope in the area. Serum albumin, transferrin, recom- binant proteins, virus capsids etc. are used as carrier for drug and biomolecules. Co...

journal_title：Protein and peptide letters

authors： Mukherjee B,Karmakar SD,Hossain CM,Bhattacharya S

更新日期：2014-01-01 00:00:00

abstract：:Natural, synthetic and analogues of peptides have shown prospects for application in cancer chemotherapy. Notably, some food protein-derived peptides are known to possess anticancer activities in cultured cancer cells, and also in animal cancer models via different mechanisms including induction of apoptosis, cell cyc...

journal_title：Protein and peptide letters

authors： Rajendran SR,Ejike CE,Gong M,Hannah W,Udenigwe CC

更新日期：2017-01-01 00:00:00

abstract：:BmK ITa1 cDNA was cloned and highly expressed in E. coli and insect cell. SDS-PAGE and western blot analysis revealed that subunit molecular weight of expression products is about 40 kDa and 10 kDa respectively. The expression product purified by a Ni(2+)-IDA-sepharose 6B column was toxic for insect, which indicated t...

journal_title：Protein and peptide letters

authors： Liu Z,Yang GZ,Chi CW,Wu XF

更新日期：2002-10-01 00:00:00

abstract：:This study revealed that the content of protein S29 in ribosomes of cancer cell line A549 was distinctly low (equivalent to about 30% of that of 2BS). The conclusion was acquired based on the ratios of spot volume of ribosomal protein S29 to that of several other ribosomal proteins (S29/L37a, S29/L38, S29/S27 and S29/...

journal_title：Protein and peptide letters

authors： Zhou ZD,Bao L,Liu DG,Li MQ,Ge YZ,Huang YL,Liu WY

更新日期：2003-02-01 00:00:00

abstract：:Heat shock proteins (HSPs) consist of a large group of proteins with negligible expressions under physiological conditions. Their expressions are highly induced under stress conditions and they are ubiquitously expressed in various tissues and organs. HSPs possess chaperone functions, thus facilitating the correct fol...

journal_title：Protein and peptide letters

authors： Lu WJ,Lee NP,Fatima S,Luk JM

更新日期：2009-01-01 00:00:00

abstract：:Background. Obesity is a major health problem in both developed and emerging countries. Obesity is a complex disease whose etiology involves genetic factors in strong interplay with environmental determinants and lifestyle. The discovery of genetic factors and biological pathways underlying human obesity is hampered b...

journal_title：Protein and peptide letters

authors： Martelli PL,Fontanesi L,Piovesan D,Fariselli P,Casadio R

更新日期：2014-01-01 00:00:00

abstract：:Glucagon-like peptide-1 (GLP-1) was once considered as an ideal anti-diabetic candidate for its important role in maintaining glucose homeostasis through the regulation of islet hormone secretion, as well as hepatic and gastric function. However, the major therapeutic obstacle for using native GLP-1 as a therapeutic a...

journal_title：Protein and peptide letters

authors： Chen W,Zhou Y,Zhang H,Qian H,Huang W,Yang B,Han J,Zhou J,Chi Y,Ni S

更新日期：2012-02-01 00:00:00

abstract：:Though protein folding is a regular phenomenon inside the cellular milieu, slight differences in the folding pattern of proteins may lead to disease-causing forms. Many diseases have been identified that are caused by these misfolded macromolecules and a considerable amount of focus is still directed towards better un...

journal_title：Protein and peptide letters

authors： Nayeem MS,Khan RH

更新日期：2004-12-01 00:00:00

abstract：:Colon cancer is one of the most common malignances. In vitro and in vivo study show that retinoic acids inhibit a wide variety of cancer cells but the molecular mechanism of their anti-tumor effects are not yet fully understood. Alltrans retinoic acid (ATRA), an isomer of retinoic acid, can inhibit the proliferation o...

journal_title：Protein and peptide letters

authors： Zhao J,Wen G,Ding M,Pan JY,Yu ML,Zhao F,Weng XL,Du JL

更新日期：2012-12-01 00:00:00

abstract：:The aim of this study was to design and develop stable nanoemulsion formulations containing IFN-γ to probe their use as an immunomodulating agent. The nanoemulsions comprising distilled water, triglycerides of capric acid/caprylic, sobitan-oleate (SP), polysorbate 80 (TW) and propylene glycol (PG) were prepared throug...

journal_title：Protein and peptide letters

authors： Ribeiro EB,Honorio-França AC,França EL,Soler MA

更新日期：2016-01-01 00:00:00

abstract：:The physiological stability curve--a plot of the free energy of unfolding versus temperature--is calculated for hen egg white lysozyme from a combination of extrapolated unfolding thermodynamic data from reversible conditions and isothermal titrations with guanidine hydrochloride. The shape of the curve suggests the e...

journal_title：Protein and peptide letters

authors： Younvanich SS,Britt BM

更新日期：2006-01-01 00:00:00

abstract：:Proteases have been used not only for proteolysis but also in organic solvent-assisted religation processes. Here, we demonstrated the effect of salts on peptide bond resynthesis in Glutathione-S-transferase (GST) and have found it to be in the purview of the Hofmeister phenomena. Our results show that the efficiency ...

journal_title：Protein and peptide letters

authors： Kishan KV,Sharma A

更新日期：2010-01-01 00:00:00

abstract：:Aspergillus sp. phytase contains five disulfide bonds. In order to elucidate their role, the reactivation and refolding of phytase in the absence and presence of dithiothreitol (DTT) was investigated. The results indicated that the disulfide bonds play an important role in the catalytic activity and conformational sta...

journal_title：Protein and peptide letters

authors： Song GY,Wang XY,Wang M

更新日期：2005-08-01 00:00:00

abstract：:Hepatitis C virus (HCV) triggers coordinated innate and adaptive response in host cell. HCV genome and proteins of the replicating virus are recognized as non-self-antigens by host cell to activate Toll Like Receptors (TLRs). Activated TLRs ultimately express cytokines, which can clear virus either by activating inter...

journal_title：Protein and peptide letters

authors： Farooqi ZU,Tareen SH,Ahmed J,Zaidi NU

更新日期：2016-01-01 00:00:00

abstract：:The Saccaromices cerevisiae D-serine dehydratase is a pyridoxal 5'-phosphate dependent enzyme that requires zinc for its function. It catalyses the conversion of D-serine into pyruvate and ammonia with the K(m) and k(cat) values of 0.39 mM and 13.1 s(-1) respectively. In this work, a new methodology for monitoring D-s...

journal_title：Protein and peptide letters

authors： Staiano M,Strianese M,Varriale A,Di Giovanni S,di Mase DS,Dell'Angelo V,Ruggiero G,Labella T,Pellecchia C,D'Auria S

更新日期：2012-06-01 00:00:00

abstract：:Globulins are a major class of seed storage proteins which were thought to be enzymatically inactive. These proteins belong to the most ancient cupin superfamily. They can be graded into 11S legumin type and 7S vicilin type based on their sedimentation coefficients. Members from both classes share structural homology ...

journal_title：Protein and peptide letters

authors： Kesari P,Neetu,Sharma A,Katiki M,Kumar P,Gurjar BR,Tomar S,Sharma AK,Kumar P

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Protealysin, a zinc metalloprotease of Serratia proteamaculans, is the prototype of a new group within the peptidase family M4. Protealysin-like proteases (PLPs) are widely spread in bacteria but are also found in fungi and archaea. The biological functions of PLPs have not been well studied, but published d...

journal_title：Protein and peptide letters

authors： Chukhontseva KN,Salnikov VV,Morenkov OS,Kostrov SV,Demidyuk IV

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:In the last years, Antimicrobial Peptides (AMPs) and lipopeptides have received attention as promising candidates to treat infections caused by resistant microorganisms. OBJECTIVE:The main objective of this study was to investigate the effect of repetitive KLFK motifs and the attachment of aliphatic acids t...

journal_title：Protein and peptide letters

authors： Húmpola MV,Rey MC,Spontón PG,Simonetta AC,Tonarelli GG

更新日期：2019-01-01 00:00:00

abstract：:Highly efficient coupling reagents, N-methanesulphonyloxy-2-phenyl benzimidazole and N - p-toluenesulphonyloxy-2-phenyl benzimidazole were designed, synthesized and successfully applied in peptide coupling reactions. Their efficiency was evaluated by synthesizing a number of structurally different amides and peptides ...

journal_title：Protein and peptide letters

authors： Kokare ND,Nagawade RR,Rane VP,Shinde DB

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Prmt5 plays major role in regulation of gene expression, RNA processing, cell growth and differentiation, signal transduction, germ cell development, etc., in mammals. Prmt5 is also related to cancer. Knowing the proteins interacting with Prmt5 is important to understand Prmt5's function in cells. Although t...

journal_title：Protein and peptide letters

authors： Shen H,Zhang X,Al Hafiz MA,Liang X,Yao Q,Guo M,Xu G,Zhong X,Zhou Q,Zhao H

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:A core sequence (the 9 C-terminal residues) of calcification-associated peptide (CAP- 1) isolated from the exoskeleton of the red swamp crayfish was previously shown to control calcium carbonate precipitation with chitin. In addition, a modified core sequence in which the phosphorylated serine at the N termi...

journal_title：Protein and peptide letters

authors： Usui K,Yokota SI,Ozaki M,Sakashita S,Imai T,Tomizaki KY

更新日期：2018-01-01 00:00:00