Abstract：
:The capacity of hepatocytes and cholangiocytes to contribute to their own maintenance has long been recognized. More recently, studies have indicated the presence of both intra-hepatic and extra-hepatic stem/progenitor cell populations. The intraorgan compartment probably derives primarily from the biliary tree, most particularly the most proximal branches, i.e. the canals of Hering and smallest ductules. The extra-organ compartment is at least in part derived from diverse populations of cells from the bone marrow. These three tiers of liver cell regeneration serve to maintain the normal organ and to regenerate damaged parenchyma in response to a variety of insults. The nature and extent of the insult determines the balance between these stem/progenitor compartments.
journal_name
Cytotechnologyjournal_title
Cytotechnologyauthors
Theise NDdoi
10.1023/A:1024826823194subject
Has Abstractpub_date
2003-03-01 00:00:00pages
139-44issue
2-3eissn
0920-9069issn
1573-0778journal_volume
41pub_type
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