Shortened protocol in practical [11C]SA4503-PET studies for sigma1 receptor quantification.

Abstract:

:In practical positron emission tomography (PET) diagnosis, a shortened protocol is preferred for patients with brain disorders. In this study, the applicability of a shortened protocol as an alternative to the 90-min PET scan with [(11)C]SA4503 for quantitative sigma(1) receptor measurement was investigated. Tissue time-activity curves of 288 regions of interest in the brain from 32 [(11)C]SA4503-PET scans of 16 healthy subjects prior to and following administration of a selective serotonin reuptake inhibitor (fluvoxamine or paroxetine) were applied to two algorithms of quantitative analysis; binding potential (BP) was derived from compartmental analysis based on nonlinear estimation, and total distribution volume (tDV) was derived from Logan plot analysis. As a result, although both BP and tDV tended to be underestimated by the shortened method, the estimates from the shortened protocol had good linear relationships with those of the full-length protocol. In conclusion, if approximately 10% differences in the estimated results are acceptable for a specific purpose, then a 60-min measurement protocol is capable of providing reliable results.

journal_name

Ann Nucl Med

authors

Sakata M,Kimura Y,Naganawa M,Ishikawa M,Oda K,Ishii K,Hashimoto K,Chihara K,Ishiwata K

doi

10.1007/s12149-007-0088-x

subject

Has Abstract

pub_date

2008-02-01 00:00:00

pages

143-6

issue

2

eissn

0914-7187

issn

1864-6433

journal_volume

22

pub_type

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